Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5.8 1.2e+03 -0.4 0.0 40 79 99 138 97 158 0.78

2 3 4.4e-23 9.5e-21 74.0 0.2 5 109 174 278 170 279 0.93

3 3 4.4 9.4e+02 -0.0 0.0 78 107 279 308 277 311 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5.8	1.2e+03	-0.4	0.0	40	79	99	138	97	158	0.78
2	3	4.4e-23	9.5e-21	74.0	0.2	5	109	174	278	170	279	0.93
3	3	4.4	9.4e+02	-0.0	0.0	78	107	279	308	277	311	0.80

Coding Sequence: ATGGCACGAAGTCACACAACAGTAAAAATAGTTCCAACCATACATGAATGGACAATTGAGAATTTTGGTATGCATCTAGAACGTTCTGAAAAGAGCAAAGATACGTTGGTATTGAATTCGTCGTCATTTTTGCTAGCCAATACCAGAAACAGTAGATGGTTTCTTCAACTAACATTTTTTGGAAATACACATGAACAAAAAGATTTGGTGATGGTTCGTGCAGTTTCTGAGATACTTAATCCAgcaaatacaatttttgcaTCAGtggatttcaatttttctgctAAAGGATCAATATTTCGAGGCAATCGCATACCTACTCAAGATATTGCGAAAGTACATTACGTAGATGTGCAATTTCAGAAGCATTCATTACTGATGAACAAGATATTTCCGCCAAATGTTGCATTTACAATAACTTGTCAAATTAATGTGATGGGCGATACAATCAcagttgggaaaaaaaattatgttccAAAGAAAGTGcataattgtttatcaaatgatCTTGGTAGTCTTTTGATAGAAGGAAAATATgctgatttttcatttacactaCGCAACAAGAAGCGATTGAAAGTACATAAAGCTATTTTGTCAGCACGGAGTCAGGGATTTGAAGATATGTTTGAAACTCTCCGATCACAGCATGGAAATCCTGATGAAATGGATGTTTCTAATGTTGATTCGAatctatttgaaaaattgattgagtaTATTTATAAGGATCAGGTATACAATCTCGAGTATTACGCTATGGATTTATTACCTTTAGCTGATGTGTATCAGTTGAAAGGTCTTATAGAGATGTGTGGAGATGCTCTTTgccaaaatatttccattgaaaatGCAGCAGAAATACTCGTGTTGGCTGATCGTCATAATGTGACAACATTGCTGAATTTTGCTCTGGATTTTACGAAAAACCACATTGATGCGGTGGTACACACGGAGGGATACACTAAGATGGAGAGTGAATTTCCGCAAATAACATTGAAGCTTCATCGACAGTTACTTGTACACAAATCTCGTGGCGGAAAGTATgcaaagatataa
Protein Sequence: MARSHTTVKIVPTIHEWTIENFGMHLERSEKSKDTLVLNSSSFLLANTRNSRWFLQLTFFGNTHEQKDLVMVRAVSEILNPANTIFASVDFNFSAKGSIFRGNRIPTQDIAKVHYVDVQFQKHSLLMNKIFPPNVAFTITCQINVMGDTITVGKKNYVPKKVHNCLSNDLGSLLIEGKYADFSFTLRNKKRLKVHKAILSARSQGFEDMFETLRSQHGNPDEMDVSNVDSNLFEKLIEYIYKDQVYNLEYYAMDLLPLADVYQLKGLIEMCGDALCQNISIENAAEILVLADRHNVTTLLNFALDFTKNHIDAVVHTEGYTKMESEFPQITLKLHRQLLVHKSRGGKYAKI

Sequence clustering based on sequence similarity using MMseqs2