Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.13 1e+02 4.9 0.0 26 43 66 83 58 88 0.89

2 6 0.016 12 7.9 0.2 21 52 89 120 86 121 0.88

3 6 1.5 1.2e+03 1.5 0.0 21 43 117 139 115 145 0.89

4 6 0.013 10 8.1 0.1 21 44 145 168 141 176 0.87

5 6 0.0072 5.5 9.0 0.0 21 52 173 204 168 206 0.85

6 6 2.8 2.2e+03 0.7 0.0 21 45 201 225 196 231 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.13	1e+02	4.9	0.0	26	43	66	83	58	88	0.89
2	6	0.016	12	7.9	0.2	21	52	89	120	86	121	0.88
3	6	1.5	1.2e+03	1.5	0.0	21	43	117	139	115	145	0.89
4	6	0.013	10	8.1	0.1	21	44	145	168	141	176	0.87
5	6	0.0072	5.5	9.0	0.0	21	52	173	204	168	206	0.85
6	6	2.8	2.2e+03	0.7	0.0	21	45	201	225	196	231	0.83

Coding Sequence: ATGGATGAAAATGTCGATTTATTAGTGCCAGAAGTTCAACTTGAGGAGtgtAAAGAGGAGCCAGAGTGGGCACAGCAGACAAATGCAGACAGAATACCAGGACCTGGGTACCTCTGCAGTGTTTGCAACAAGGTTCTTGCCACTCTCAATGAACACAAATTCCACGAATGGTCACATGCAACAGGACGACAGTTTGAGTGTCCTGACTGTGGCAAGGTGTTTCGTAGATCCACACATCTTAAAAGTCATGCCGTTGTGCATGAAACGGAGATGCCTTTGGAGTGCACTGTCTGTGGGAAACGTTTCCGTCGCATTGTGAATCTCCGAGCTCATACTCGTCTTCACACTGGTGAAAAACCATTTAAGTGCCAGGACTGTGGAAGGACATTCAGGGAAAGTGGACATCTGAAGAACCATGCATTGATCCACACTGGAGAAAAGCCGTACTCGTGTGATATTTGCAACAAGCCATTCCGTGATAATGCAGCTCTTAAACGTCACAGACTAATCCACACTGGGGAGAAGCCGTATGACTGTACAACATGTGGCAAGTCATTTCGGGAGTCAGGACAACTAAGAAAGCACATCCGTACACATACAGGCGAGAAACCTTATGTTTGTGTGTACTGTGGTAAACGTTTTACAATATCAACAAACCTGATAGCTCATATGAAAACACATGCAAAAGATGGACACAAAGAAGAAAAGCCACAGACTTCATAA
Protein Sequence: MDENVDLLVPEVQLEECKEEPEWAQQTNADRIPGPGYLCSVCNKVLATLNEHKFHEWSHATGRQFECPDCGKVFRRSTHLKSHAVVHETEMPLECTVCGKRFRRIVNLRAHTRLHTGEKPFKCQDCGRTFRESGHLKNHALIHTGEKPYSCDICNKPFRDNAALKRHRLIHTGEKPYDCTTCGKSFRESGQLRKHIRTHTGEKPYVCVYCGKRFTISTNLIAHMKTHAKDGHKEEKPQTS

Sequence clustering based on sequence similarity using MMseqs2