Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.046 35 6.4 0.0 21 52 132 163 121 164 0.84

2 6 0.16 1.2e+02 4.7 0.1 22 50 185 213 181 216 0.83

3 6 0.33 2.5e+02 3.7 0.0 22 52 213 243 210 245 0.85

4 6 0.12 91 5.1 0.2 22 52 269 299 260 300 0.86

5 6 0.094 72 5.4 0.0 22 51 297 326 294 328 0.85

6 6 0.023 17 7.4 0.0 22 44 325 347 321 350 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.046	35	6.4	0.0	21	52	132	163	121	164	0.84
2	6	0.16	1.2e+02	4.7	0.1	22	50	185	213	181	216	0.83
3	6	0.33	2.5e+02	3.7	0.0	22	52	213	243	210	245	0.85
4	6	0.12	91	5.1	0.2	22	52	269	299	260	300	0.86
5	6	0.094	72	5.4	0.0	22	51	297	326	294	328	0.85
6	6	0.023	17	7.4	0.0	22	44	325	347	321	350	0.91

Coding Sequence: ATGGATTACAGCATAGAGATTAAAAAAGAACCACTTAACTGCAATGCTTATTCAGTTGAAGTGAAAtctgagaaaaaagaagaagagtcTTATGATGCTGATGATGGTGAAAATGATTGTGGAGTGTTAAGATATGAGGAGGAGAAAAAGGTTGACATAGCTTTAATAAAGAAGGAGATCACAGTTGAGGCATTCAACTTTCCAGCCAGTGATGCAGGGTCTAATAATAAAGAAGACTTGTCCAGTTGTTTGGAAAATTCAACCAGAGCATCTTGTATTGAAATTGCACTGAACTGTAAAGATAAAACAGATTGTAAATTATATGATAGTTCTTTCACTGCTTCATCTATAAAAGGGTatgaacataaaaagaagaaTAATGTGATGCATGAGGCCAACAGGCCATATAAGTGTGAAGtgtgtgggaaaggatttacacaGACACCTACTTTgagaaaacatcttttgattcataaagGCAAGAAAccacacaaatgtgaaagttttacccaAGCATCTACCTTAAAGGGACATCTCCTGACTCATGAAGGAAAaaaaccacataagtgtgaaatttgtgggaggAGTTTTACAAAACTGGCTAATTTAAgagaacatattttaattcatgaaggcaagaagccacataaatgtgaagtctgtgggaaaggatttacccAGGTATCTACTTTCAGGAAGCATCTTTTGGTACATGAgagcaagaaaccacataaatgtgaagtttgtgggaagaatttTACCGTGTTAtctcatttaaaaaaacatactttgattcatgagggtaaaaagccacataaatgtgaaatttgtggaaaatgttttagCCAAGCTCCTCATTTAAAGGAACATCTCTTGATTCATGAGGGCCAGAAGCCTCATAAATGTgtagtttgtgggaagagttttacccaAGTATCAAATTTAAAGgtacatcttttaattcatgatggcaagaaaccacataagtgtgaaatttgtggaaaaggatTTACACAGTCATCTTCTTTGACAAGACATCTTTTAACTCATAagtga
Protein Sequence: MDYSIEIKKEPLNCNAYSVEVKSEKKEEESYDADDGENDCGVLRYEEEKKVDIALIKKEITVEAFNFPASDAGSNNKEDLSSCLENSTRASCIEIALNCKDKTDCKLYDSSFTASSIKGYEHKKKNNVMHEANRPYKCEVCGKGFTQTPTLRKHLLIHKGKKPHKCESFTQASTLKGHLLTHEGKKPHKCEICGRSFTKLANLREHILIHEGKKPHKCEVCGKGFTQVSTFRKHLLVHESKKPHKCEVCGKNFTVLSHLKKHTLIHEGKKPHKCEICGKCFSQAPHLKEHLLIHEGQKPHKCVVCGKSFTQVSNLKVHLLIHDGKKPHKCEICGKGFTQSSSLTRHLLTHK

Sequence clustering based on sequence similarity using MMseqs2