Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.034 26 6.8 0.0 21 45 106 130 99 137 0.85

2 6 0.042 32 6.5 0.0 21 52 134 165 130 166 0.86

3 6 0.72 5.5e+02 2.6 0.1 21 48 162 189 160 195 0.83

4 6 0.23 1.8e+02 4.2 0.0 21 44 190 213 182 218 0.89

5 6 0.25 1.9e+02 4.0 0.0 21 44 218 241 214 245 0.90

6 6 0.004 3.1 9.8 0.0 21 49 246 274 243 276 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.034	26	6.8	0.0	21	45	106	130	99	137	0.85
2	6	0.042	32	6.5	0.0	21	52	134	165	130	166	0.86
3	6	0.72	5.5e+02	2.6	0.1	21	48	162	189	160	195	0.83
4	6	0.23	1.8e+02	4.2	0.0	21	44	190	213	182	218	0.89
5	6	0.25	1.9e+02	4.0	0.0	21	44	218	241	214	245	0.90
6	6	0.004	3.1	9.8	0.0	21	49	246	274	243	276	0.93

Coding Sequence: ATGGGTGTGATGAAGACTGCACTGCCACGTCGTACAGACAGTCGCTCTGCTAATCTCAAAAGGACTGTGGGGAAGTACATCTGTAAGCACTGTGGCAACATTTTTGAGTCCTTTGAAGAATTTGAGAGACATGTTCGCTCCCATGTCCCAGCAAAGCCCTTCTGCTGTACACTGTGTGGCAGAAGTTACATGCATAAAGGGCATCTGAAGGAGCATGTAGCAACACACAGTGACCGAAAGCCTCATGTGTGTGCACTTTGTGGCAAGAGTTTTGCACACAAAGGGGACTTGACGATTCATACAAGGATACACACTGGAGAGAAGCCCTATACATGTAAAGTATGCAACAAGGCATTTGTCCAGGGTGGTCAGCTCAAGATGCATATGCGCACTCATACTGGAGAGAAGCCCTATGTGTGCAGCATTTGTGGCAAAGCTTTTGTACAGAAGCACAACATGCTAGATCATATGTTCCTTCATACAGGCGAGAAGCCGTATTCATGCACGCTGTGTGAGCGGAGTTTTGTGCAGGGCTGCCATCTCAAGGACCATATGAAGACACACTCAGGGGAGAAGCCCCATATGTGTAGCTTCTGTGGCAAAACATTCCTGCAGAATTCAGACCTGCGAGTTCATATGCGGGGCCACACAGGGGAGAAGCCCTTCTCATGCACCCAGTGCAATAAGAAGTTCGCTCGCTCAGGAGTTCTCAAACGCCATTTGTTGACACATACTGGAGAGAAGCCATACAAATGTGATCTCTGTGGCAAGCAATACACCCAGGGTAGCAAGCTCAAGAGACACCTGGGTATGCAGCATGTGGGCTTCTCAACGTGA
Protein Sequence: MGVMKTALPRRTDSRSANLKRTVGKYICKHCGNIFESFEEFERHVRSHVPAKPFCCTLCGRSYMHKGHLKEHVATHSDRKPHVCALCGKSFAHKGDLTIHTRIHTGEKPYTCKVCNKAFVQGGQLKMHMRTHTGEKPYVCSICGKAFVQKHNMLDHMFLHTGEKPYSCTLCERSFVQGCHLKDHMKTHSGEKPHMCSFCGKTFLQNSDLRVHMRGHTGEKPFSCTQCNKKFARSGVLKRHLLTHTGEKPYKCDLCGKQYTQGSKLKRHLGMQHVGFST

Sequence clustering based on sequence similarity using MMseqs2