Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 4.1 3.1e+03 0.2 0.0 26 44 37 55 32 63 0.83

2 11 0.0094 7.2 8.6 0.1 22 52 61 91 57 93 0.89

3 11 0.066 51 5.9 0.0 22 48 89 115 84 120 0.83

4 11 0.0044 3.3 9.7 0.1 22 51 117 146 113 148 0.85

5 11 0.67 5.1e+02 2.7 0.0 22 48 145 171 142 175 0.84

6 11 0.21 1.6e+02 4.3 0.0 22 45 173 196 170 203 0.83

7 11 0.17 1.3e+02 4.6 0.2 22 46 201 225 198 232 0.86

8 11 0.82 6.3e+02 2.4 0.1 22 51 229 258 226 260 0.83

9 11 1.5 1.2e+03 1.5 0.0 22 48 257 283 253 288 0.82

10 11 4.7 3.6e+03 -0.0 0.0 22 44 285 307 280 315 0.81

11 11 0.18 1.4e+02 4.5 0.1 22 45 313 336 309 343 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	4.1	3.1e+03	0.2	0.0	26	44	37	55	32	63	0.83
2	11	0.0094	7.2	8.6	0.1	22	52	61	91	57	93	0.89
3	11	0.066	51	5.9	0.0	22	48	89	115	84	120	0.83
4	11	0.0044	3.3	9.7	0.1	22	51	117	146	113	148	0.85
5	11	0.67	5.1e+02	2.7	0.0	22	48	145	171	142	175	0.84
6	11	0.21	1.6e+02	4.3	0.0	22	45	173	196	170	203	0.83
7	11	0.17	1.3e+02	4.6	0.2	22	46	201	225	198	232	0.86
8	11	0.82	6.3e+02	2.4	0.1	22	51	229	258	226	260	0.83
9	11	1.5	1.2e+03	1.5	0.0	22	48	257	283	253	288	0.82
10	11	4.7	3.6e+03	-0.0	0.0	22	44	285	307	280	315	0.81
11	11	0.18	1.4e+02	4.5	0.1	22	45	313	336	309	343	0.86

Coding Sequence: ATGCATGAGTCTAAAACTAAACATAAGTGTAAAGTCTGTGAAAAAAGTTTTACTCAGGCATCAGCATTGTTAaaccatattttgattcatgagggcaagaaactacacaagtgtgaagtttgtggcaagagTTTTAATCAGCCATCTaaattgaaaaaacatcttctgaATCATGAGGACAAAAAGCCttataagtgtgaaatttgtgagaaAGCATTTACTCAAGCATCTCATTTGAGGGGACACCTATCCATTCATGAGGGCAAtaaaccacataagtgtgaatTTTGTGGTAAGAGTTTTACTCAGGCAGGTAATATGAGGAAACATGTTTTGATTCATGAGGACAAGAAaccccataaatgtgaagtttgtggtaagagctttaaCCAAATATCTAATTTGAGGaagcatcttttgattcatgaggggaaaaagccccataagtgtgaagtttgtggaaagagctttacccaggcatctaCTTTggggaaacatcttttgattcacgaaGGCAAGAAGCCTTTTATGTGTGAactttgtgggaagagttttacccaTTCATCTACTCTAAGAAAACATCTTTTgactcatgagggtaagaagccatataaatgtgaaatttgtggtaaATGCTTTACACAAACATCTCATTTGAGAGGGCATATtgtgattcatgagggcaaaaggCCACATAAGTGTACAGtatgtggaaagagctttacccatgCATCTACTTTAAGggctcatcttttgattcatgagggcaagaagccccacaaatgtgaagtttgtggaaagagctttacccagacatctCATTTGAAGGGACACAtgttgattcatgagggcaaaaagcctCATAATTGCAGTGTTTGTGGGAAAACATTTACACATGCATCTCATTTGAGGGGACATAGTTTGAtacatgagggcaagaagccatataaatgtgaGGTTTGTGAGAGAAGCTTTACTCAGACATCTCATTTGAGGACACATCTGTTGGTACATGAGGGCAAGAGACCTTTTAAGCATGAAATTTGTGGGAAGGGCTATATCCATTTATCTAATTTAGAAGGTAAAACATAG
Protein Sequence: MHESKTKHKCKVCEKSFTQASALLNHILIHEGKKLHKCEVCGKSFNQPSKLKKHLLNHEDKKPYKCEICEKAFTQASHLRGHLSIHEGNKPHKCEFCGKSFTQAGNMRKHVLIHEDKKPHKCEVCGKSFNQISNLRKHLLIHEGKKPHKCEVCGKSFTQASTLGKHLLIHEGKKPFMCELCGKSFTHSSTLRKHLLTHEGKKPYKCEICGKCFTQTSHLRGHIVIHEGKRPHKCTVCGKSFTHASTLRAHLLIHEGKKPHKCEVCGKSFTQTSHLKGHMLIHEGKKPHNCSVCGKTFTHASHLRGHSLIHEGKKPYKCEVCERSFTQTSHLRTHLLVHEGKRPFKHEICGKGYIHLSNLEGKT

Sequence clustering based on sequence similarity using MMseqs2