Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0053 4.1 9.4 0.0 20 51 9 40 7 42 0.86

2 8 2.8 2.2e+03 0.7 0.1 23 52 40 69 35 71 0.82

3 8 0.013 9.8 8.2 0.0 22 51 67 96 64 98 0.85

4 8 0.92 7.1e+02 2.2 0.0 20 47 93 120 91 125 0.83

5 8 0.055 42 6.2 0.0 22 45 123 146 119 153 0.85

6 8 0.27 2e+02 4.0 0.0 20 48 149 177 147 182 0.83

7 8 1.2 8.8e+02 1.9 0.1 22 47 179 204 175 209 0.83

8 8 0.024 18 7.3 0.0 22 46 207 231 204 235 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0053	4.1	9.4	0.0	20	51	9	40	7	42	0.86
2	8	2.8	2.2e+03	0.7	0.1	23	52	40	69	35	71	0.82
3	8	0.013	9.8	8.2	0.0	22	51	67	96	64	98	0.85
4	8	0.92	7.1e+02	2.2	0.0	20	47	93	120	91	125	0.83
5	8	0.055	42	6.2	0.0	22	45	123	146	119	153	0.85
6	8	0.27	2e+02	4.0	0.0	20	48	149	177	147	182	0.83
7	8	1.2	8.8e+02	1.9	0.1	22	47	179	204	175	209	0.83
8	8	0.024	18	7.3	0.0	22	46	207	231	204	235	0.89

Coding Sequence: ATGAAgcaacatattttgattcatcagggcaagaaaccacataaatgtgatgtttgtgggaagagctttacccagatcTCTAATCTGAgggtacatcttttgattcatgaaggcagaaagccccataaatgtgaagtttgtgggaaaagatttactCGTGCAACTACTTTAAGGGATCACACTTTGATTCATGAAGTCAAAAAACcgcataagtgtgaagtttgtgggaagagttttacccaGCCATCTAATTTGAggggacatcttttgattcatcagGGCAAGAAGCCATAtgagtgtgaagtttgtggtaagagtTTTAGCAAAGCATCTGCTTTGAGGGACCATGtattgattcatgaaggtaaaaagccacataagtgtgaattTTGTGAGAAAAGCTTCACCCAGGCTTCTAATTTGAGGGGacatattttgattcatcaaGGCAAGAGGCCCCATAAGTGTAAAATTTGTGGGAAAGATTTTACCCAAGCATCCACTTTAAAAGGGCACATTTTGATTCACGAGGGCAAAAAGCctcataagtgtgaagtttgtagGAAAAGCTTTACTCATGCAACTACTTTGAGAAACCATGTTTTCATTCACgaaggtaagaaaccatataaatgtgaagtctgTGGTAAGAGCTTTACTAAGACATCGAATTTGAGAAAACATCTTATGATTCATGAGGGAAAAAGTCTGAATTTTGTAGAAACAAATTTTCCAGAATTTGAAGAACCACCTGTTAATATTTTAGGGCATTAA
Protein Sequence: MKQHILIHQGKKPHKCDVCGKSFTQISNLRVHLLIHEGRKPHKCEVCGKRFTRATTLRDHTLIHEVKKPHKCEVCGKSFTQPSNLRGHLLIHQGKKPYECEVCGKSFSKASALRDHVLIHEGKKPHKCEFCEKSFTQASNLRGHILIHQGKRPHKCKICGKDFTQASTLKGHILIHEGKKPHKCEVCRKSFTHATTLRNHVFIHEGKKPYKCEVCGKSFTKTSNLRKHLMIHEGKSLNFVETNFPEFEEPPVNILGH

Sequence clustering based on sequence similarity using MMseqs2