Basic Information

Insect: Metalampra italica
Gene Symbol: MBD-R2
Assembly: GCA_949699065.1
Location: OX452972.1:9849613-9862724[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7.8e-17 1.9e-13 50.1 0.1 5 64 790 848 786 910 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7.8e-17	1.9e-13	50.1	0.1	5	64	790	848	786	910	0.81

Sequence Information

Coding Sequence: ATggtgataaaaaaatgttgtattgCGAATTGTAATTCGTGTTCAACACGGAAGGAAGATGTTGGTGTCACTTACCACAAGTTCCCAAAAGACTCAACATTGCACAACAGTTGGATAACGGTTACATGTCACAAACATACAGATCTACCATCATTTGTGTGCTCAAGGCATTTCCGTAAaagagattttaaaatttacaaggACTCGAAATATGTTCTGAAGCCAGATGCAATACCATCAATATTTCCTTGGGCAGtaactaacaataataaaaataaatcagcaACTACAAAAATGGAGAAACAAGAAACTGCAGAAGAGGCTAATGAGGATGCAATAGAAACATTAAACAGCAGTAAAGGATCAGAGGGAGAAAACTTAGAAGCAATTAAAAAGTTCATTGAAGATCAAGAGAAGGACATTTTAGAGCAGAAATTGAAAAACGAACCTGATGAAACAGCTATAGAAAGTGATCCTCCATCCCAGGTTTCTGAACAAGATGGGAATGCAGAAGTAGCAGCACCAGTGGACATTGTGAAAGATGACGGAGATAATCCAGTTAAAGATGACAATAAAGCAGACGAAACTGAAAACCTAACAGAAAAAGTAGGAGATAAAGAAGCACAAGATGAAACGATGGCGGTTGCAAGCAGTGTCATGGATATGATTCTAAGTGAATCGGAAGCTAAAGTTACTAGGAAGAAAGATTCAAAGCTACTTGGCAAACAGACCCCTGCAGAGAAAGCAAACAGCAGCATGGCCCTGTCAGTGGGCTCCAAAGTGGAAGCGAAGGACTTTAGCGAGGACTGGTACCCAGCTCAGATAGTGGAGGTCGATTACGAGGAGATGGAAGTGCTGGTTCATTACGAGAATGTGtcaaaaaaACATGACGAATGGATAAGCGTGAGCAGTCCTCGGCTCAGACCGATAGGCAGTCCCTCAACGAAGCCTCTAACGCCGGCACCAGAAGCACCAAGCACCGAAGTGAGCGCCCCAGACACTGTGCAAGTGAAAGAGGAGCCAAAGCCAGAGGAGAAGTATCAACTGATGTTCGTGGTTGGTGAGAGATGTCTGGCGCGATGGAGAGACAATCGGAGATTCATTGCTACTATATGTGAAGATTTGGGTCATGGAAAATACGAGATAATATTTGATGATGGAGTCCGTTGGGTATGCGCTACGTCGAGGCTGCGCAAACTGAAAGAACCGACGAAGAACGACCCCCTGACCGTCGACACGACGTTCTCCCCCCCCGGCACCTCCACCCCCTCGCCGGAGGACGCCCCTGGCCCGGGTGCCGCCGCCTCCACCCCCCTCCCCGCGTACCACACCCACCTCTTTGACCCCGCCCGTGATTATCTAGGTTCGAAAAGCGAACGACGCGAAATGAAAcgtaaattaaacattaaggAGATATTCAATATTGGTcagaagaaaaagaagattGAAACAACGCCAAATGAAAGGCCGCAGAGGGTCGTCAAGGAAAAGAAGGCAAAGGTTGTTAAAAACAAAGTGAAATTAGAGCCTGAGGCAAAGGTGAAGACAGAGGTAAAGACGGAGATACCTGACGCAGTAGCTTCAATAATCGGCACTTTTGCACAAGACGTTAAAACCACatcagatataaaagaagCAATAATTATAGAGGCTGTTGATATTAAGGAGGAGATAGATATTGATGACTTGAAAATAGACATCGATGATGACATGGCGAATAGCGAAACTCTAAGTGCTCCGGAATCGCAAGACATAAGGCATGGAGACGATCCTGTAAGTTGCATTTGGATACCATTTTCAATAAGGTTCAAGTTAGATAAGGCACTGGACGAAGAAGTAAAACTGGAGCAGTTCGACCGACCCGACGACGCCAAGCACGAGCAAGTAATCGACAGGATAAAAGAGGTCATTACTAAACTAGAAGGCGGTTTGAACCAAGCCGAAAAAGTAGAGTCCCCTACACCAGAAACAAAACAGGAAATAAAATCGGAAGATATCAATAAACCTGTAGCCGTCGATGTCAAAGTAGAAACTGGAGAGAAACCAAAGAAAAGTCTGTCAAAGGTAAAGAAAGGTAAAAAATTGAGAATGTTACAGGAGAAAAAGGTAAAGAAACAAGTGGAGAAGGTGAAGTCTGAGTTAGAGGAGATGAAGAAGCAGGTGGAGGAGATGAGGAAGCAGATGCTGATGAAGACCGAGGAGCTGGCGAGGAACAAGCCGAGCACGGAGATGCCGGAGAGCTTCCTGCTGCCCGGGGAATGGTGCTGCAAGTGGGTAAACGGGCAGCCGGTGGGGAAGGTCAGCGAGATGATGGGCGAGACCAAACCGGACGCGAGCAGTCGGCCGGCGTTGCCGCGGAGAAGCGTGCAGgttgaAGACAAGAGACTGCCGCCTGGATGGATGAAGCACATGGTGCGAAGGAGTTTCGGCTCTTCAGCTGGGAAATGGGATGTCGTTTTGGTCAGTCCTGGAAACAAACGATTCCACACCAAAGTGGACATGCGCAACTACCTGGCGAACAACCCCGACGAGGCGCTGAAGCCTTATGAGACCGTCTTACAAGACTTCGGCGTTCACCTGAAGCTGTCCCGGCGCATGGGCTGGTACACCACCACCCCTGACGGTGAACAGGAGAACCCTATTCCCGTGCCAGCAGAGACCCTGAGCAGTACCTCGCCGCTGGTGAAGAGGAAGAACTTGAGCCTCAAGAGAAGTCTAAAGAAAAAggacaagaaaaagaaaaagttgcGTTTGAAACTGAAGGTGCCGAGGGAATATCGGTATCCGTCGCATTCCGCAACCATAGAGAGTATGCCCAGTACAAGTGGAGATGTGATGGACCACGTTTCTCTGGAACATCCTCCCTTAGAAGATGGATACGTGTATGTGGGATCGCTGAAGGTCCAAATAATCGAGAACCTCCTGCGCTGCCCGGCCGACGGGTGCTTCAAGAACTTCCGCAACGACACCCTGCTGAAGATGCACATCAAACACTACCACAGGGAGCTGAGGAAAATGCTCGGAGCAACACCGCAGGTGCTAGACTTGGCGTACGCGAGGGCCAGGCCGACCGCCATGGAAATGAGAAGACTGAAGCTCGAGGCCAAACGTaaaacaatcaaaatcaaactgCCGAGGCTGCCCAAACGCGTCTTAGACGGAAAGTCCGCCGTAAAAGACGCCACATCTAAAATACATGTCGATATACCACCAGTTAACACTGAAGGGGAGAAGTTACTAAGGCCCCAAGACTCGCCTCAACTCAGAAACGCTTTAGTAAAGAAACCAGTGCGACGACCGAAAGTCTTACTGCCTGTACGAAGACCAGAGCCAGCTGAGACAGCGCCAGATTTGATGGAAGAAGACATAGATGTTGTGGACACTCCGATGGAAGCGATAGTGGATGTGCCCCTGATGGAACCGTTGGACTTCGAGACGGCCATATCGACGCATACGGTGACAAAACCTGTAGATCTGAAACGCAAGGGTGAGAAGAAACGCAAGTCGTTCGCGAGCATAGCGAGGAAGACGGTGAGCGAGGACGAGGAGTGGTTCGCGATGAATAACTCTGATGTGGAGACGAGGTCCAGCTACCCGCGCTCCGGGACGCCGGACTCGAAGATCATGGACCAGAAACTGTTGTCGTCGGAGTCCAACGAGGACCAGAAGGATCCCAACCTGTACATGTACACGGACACCGGCGAGCGAATAAAGCTGGTGCACATGAAGCGCGAGGAGATCATAAACTGCCACTGCGGCTTCCGCGAGGAGGACGGGCTGATGGTGCAGTGCGAGCTGTGCCTGTGCTGGCAGCACGCGCTCTGCCACAACATACAGAAGGAGTCCGAGGTGCCGGAGAAGTACACGTGCAGCATATGCCTGAGCCCGCGACGGGGGCGGCGCTCGCAGCGGTTCCTGCACGACCAGGACCGGCTGTACGAGGGCCTGCTACCGGGGGCGAAGCCCTGCGAGTCGCTGCGCCGCTCGCACGAGCTCTCCGGCAACCTGCTGCGGATCGACGACGCGCTGCAAGCGCTCAGGGTGAAGTACTACGTCGCCACGAAGAAGGACCACCCGAAGCTGTACCTGTGGGCGAAGGACTGGGAGACGGGCGAGATCGCGCTCACGCAGGAGAAGCTCAACTCTGACTACTCGGACCTGAACATCATGATCAGCACCATCGACAAGGAGAACCTGCCCGTGAGGGATGAAGCGCCCCTCGGCATGGGGACGCCGCTCTCGGAGGAACACGACGGGGAAAGGTTCTCCCACAAGGAGAGTCAGCTCGGGTCCCAGGCGCTGCTGAGCGGTCTGCTGTCCAGTCCGGGGGGAGCGTCCCTCGATCTGCCGATCAGCACTTCCGAGTTGGAAAGACTCGCCAAATCTGTTCAAGAACAAGAGAGCCAGCGCGTGGGCGTGGTGGCGCCGCAGCCCGAGGCGGCCATAGAGAACAGCGCGTGTCGGGAGCGGCTGCTGCGCCACATACAGCGCTGCCAGACGCTCATCGACGCCAGGCTGGACTCCATCGAGGCGCAGGTTGCAGAGCTGGAGTCCCAGGACCCGTCGTTCGAGGACGACGAGACGGCGGACTACTTCCCACGTACCAAGCAGACCGTGCAGATGCTCATGCGGGACCTCGACACCATGGAAGAGCTCGGGGTCATCACCTGA
Protein Sequence: MVIKKCCIANCNSCSTRKEDVGVTYHKFPKDSTLHNSWITVTCHKHTDLPSFVCSRHFRKRDFKIYKDSKYVLKPDAIPSIFPWAVTNNNKNKSATTKMEKQETAEEANEDAIETLNSSKGSEGENLEAIKKFIEDQEKDILEQKLKNEPDETAIESDPPSQVSEQDGNAEVAAPVDIVKDDGDNPVKDDNKADETENLTEKVGDKEAQDETMAVASSVMDMILSESEAKVTRKKDSKLLGKQTPAEKANSSMALSVGSKVEAKDFSEDWYPAQIVEVDYEEMEVLVHYENVSKKHDEWISVSSPRLRPIGSPSTKPLTPAPEAPSTEVSAPDTVQVKEEPKPEEKYQLMFVVGERCLARWRDNRRFIATICEDLGHGKYEIIFDDGVRWVCATSRLRKLKEPTKNDPLTVDTTFSPPGTSTPSPEDAPGPGAAASTPLPAYHTHLFDPARDYLGSKSERREMKRKLNIKEIFNIGQKKKKIETTPNERPQRVVKEKKAKVVKNKVKLEPEAKVKTEVKTEIPDAVASIIGTFAQDVKTTSDIKEAIIIEAVDIKEEIDIDDLKIDIDDDMANSETLSAPESQDIRHGDDPVSCIWIPFSIRFKLDKALDEEVKLEQFDRPDDAKHEQVIDRIKEVITKLEGGLNQAEKVESPTPETKQEIKSEDINKPVAVDVKVETGEKPKKSLSKVKKGKKLRMLQEKKVKKQVEKVKSELEEMKKQVEEMRKQMLMKTEELARNKPSTEMPESFLLPGEWCCKWVNGQPVGKVSEMMGETKPDASSRPALPRRSVQVEDKRLPPGWMKHMVRRSFGSSAGKWDVVLVSPGNKRFHTKVDMRNYLANNPDEALKPYETVLQDFGVHLKLSRRMGWYTTTPDGEQENPIPVPAETLSSTSPLVKRKNLSLKRSLKKKDKKKKKLRLKLKVPREYRYPSHSATIESMPSTSGDVMDHVSLEHPPLEDGYVYVGSLKVQIIENLLRCPADGCFKNFRNDTLLKMHIKHYHRELRKMLGATPQVLDLAYARARPTAMEMRRLKLEAKRKTIKIKLPRLPKRVLDGKSAVKDATSKIHVDIPPVNTEGEKLLRPQDSPQLRNALVKKPVRRPKVLLPVRRPEPAETAPDLMEEDIDVVDTPMEAIVDVPLMEPLDFETAISTHTVTKPVDLKRKGEKKRKSFASIARKTVSEDEEWFAMNNSDVETRSSYPRSGTPDSKIMDQKLLSSESNEDQKDPNLYMYTDTGERIKLVHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQKESEVPEKYTCSICLSPRRGRRSQRFLHDQDRLYEGLLPGAKPCESLRRSHELSGNLLRIDDALQALRVKYYVATKKDHPKLYLWAKDWETGEIALTQEKLNSDYSDLNIMISTIDKENLPVRDEAPLGMGTPLSEEHDGERFSHKESQLGSQALLSGLLSSPGGASLDLPISTSELERLAKSVQEQESQRVGVVAPQPEAAIENSACRERLLRHIQRCQTLIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTVQMLMRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00994425; iTF_00674312; iTF_00674365;
90% Identity: iTF_00994425;
80% Identity: iTF_00994425;