Basic Information

Gene Symbol
MBD-R2_1
Assembly
GCA_950004255.1
Location
OX465376.1:5833209-5842038[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 6.3e-11 2.9e-07 30.0 0.1 15 72 245 300 241 305 0.87
2 3 2.6 1.2e+04 -4.0 0.0 47 59 392 404 391 408 0.79
3 3 4 1.8e+04 -5.5 2.5 13 18 603 608 599 611 0.76

Sequence Information

Coding Sequence
ATGAGTAAAAGCGGTGATAAATACTCCCAGCAGGAAGATACTCAGGATAGCTTGGGGGATGACAGTTTTTCCGCGGATAAAAGTAACTTCGTCATCGGAGCTAAGCTTGAGGCCACAGATGCAAGCGGAGTGTGGTATGCTGCCCGTGTAGAAAACGTTAATTGGGAGGAAAGAGAAGTGTTGGTGCATTTTGAGAGATGGAGTTGCAAGTTTGATGAGTGGATTCCTATGTGCTCCAATCGTCTTCGATCTATTCAGAAACCTCTCCCTCCaaAACCTCCCCCGAGATTCGAGCGTGGTCAGCAGGTGATTGCTGTTTGGTCTGCTTACAACAGATGTCCTGCGACAGTTCAGAGAGCTCTTCCAGATGGAAAATACGAGGTACTTTTTGAAGACGGGTTTGTAAAGCGCCTGCTGCCGTCCAAGATGTGGCACCTGGATGACGTGGTGAGCTCTCCGCGGAGCCCAGCTGAAGCCAGCATTGGCAGCAAGCAGGACCGCCGTGACCGCAAGCGGAAGCTCGTTGTCTCCGAGCTCTTCCGTTCCAATAAGAAGGTCAAAACGGATCCAAACGACAAAAAGACTGTGGCTGTAGCATCAACTTCTTCAGCCGTTGATGTGACTCATATGGAAGCCCCGGCCCCGCCTCCAGGCCGCAAGTCATTGCCCCCCATAGCCCACGCCCCACCTAAACCCATTGAGGTCAGACACCTGGACGGCCGCAAGGAGACGTGGCTCAAGATGCTGACACGGCGCTCTGAGGGCAAGACGGCGGGAAAACTCGAGATCGTGATTTGCTCTGCTTCTGGAAGAAAGTTTCGGTCCAGGGCGGACATAATTCGATATTGTGAAGAAAATAAGATCCTGTACGAGCCGACTCTTTTCGACTTCTCAGCTAAAGGAAGATCAAAGGCGAAATCCATCGTGCAGGGGAGCAACGAGGTTGCGGATGAAGAAGTGGTGGCACCAGTTGCGCCACCTGTCGCGCCTGACCCTCCGGTCATCCCCATGACCGCTCCGCTGACCACTCCAGAACCCGTAGAGGAAGAGCGAAGGTTCATTGGTGACTTGGAGGTCATCGTACAGGATGGCCAGTTCATTTGCCCTGTCACTGACTGCAGAAAACACTTCCGCAGGGAGAACCTCCTTCATATGCATATGAAGCATTACCACCCCGAGCTATCGAAGTACCTGGACTACACACCAAGTGTGACCGATCTAGCATATGCAAGGACTGTAAGCCTGGAACAGCAGGAAGGCAGCCCTACAGTGAGGCCGAGCCTTCGTTCTGATATCCGCTGCCCCGACGTTAAACGCTCTCCTGTGCGCATTAGGGATTGCAGAGTGGAGATGAACAAGGTGACACTGAGCACTGCTGTGGATGCCACTCCTCCTGCTACCATCCCCGAACCAGCAGAAGACGCCACCACGACGGATCCAGAACCGATACAGCCGATACAACCTCCTAGCTTGGCTGAAGTCGGCGCTTCTGTGGCGCCACATGAGGCGGTGACGGAGAGCGAGCGGGACGGGGTCGGAGGCACTGAAGGAGACTTAGAGGCGGTGATCCCTGCGAGTGTGCTGCAACGACCGAAGATACACTGGAAGCGCCGCCCCTACCACCGGCACCAGCTACCCCTTACAGATTGGTACGGGCGGATGGGAAAGCAGGCAGCAGCGGGGGGAGCAGCCAGCGAGGCTTCGGGTAAGCAGAAGGACGAAGAGTCCGGAGACCTGGTCCAACGCAACCCTATCCTGAACACGCTTCTCAGCTCGAGGCCGCTCGCCCCCACATTGGGATGGCGGCCTGGCTGGCGGAGGCGGCGGCGCGGAGGGTGGAACAAGCGCCGCCCCCCGCGCACGCTGCCTCCAGCTCTAGACCAGGGCCCAACTCCGCTCGCAGAACTCACAGATGGACTCGAAGACTCCAAACCTTCTCCAGGAGCAGACGGCAGTGACCTCTCCAAGTCTCCCGGCCCTGCTGACGGGGAGAAGTATGAAAAACTCCGCGGTAATGAAATCATCAACTGCACCTGCCAGATGAAAGAAGAGGACGGGCTCATGATACAGTGCGACGTCTGTCAGTGCTGGCAGCATGGCCATTGTCTGGGAATCGCTCCTCAGGGAGAGGTGCCGGAGTCGTATGTGTGCAGCGTGTGTAAGGACCCTCCTAAAGGGCGATCGTCTCGCAAGTACTACAACCATCAGGACTGGCTCAAGCAGGGCGTTCTTCCTACTCTTCCCTTCAAGCCAAAGTCTCCGTCGACACAGCGTCAGAACCTGCTGAAGAGGGCGTTCGAAATGAGcggtcagctgtccctactgTCTCGACTGCTGCACAGTTTGAGGGTGAAGCTGAATGTGGCCGGGAATAAGGATCATCCCAAGCTCTGGCTGTGGGCTAGACGATGGCAGGAAGCTCACAAGCCGTCTCACCCACTTCCCACTGTGAAAGAGGAAGAGCCTTCAATGCCAAAAGCACCTGAGCCCGAAAAGCCCATCGATCCTGTTGAGTGCAAAATGAATCTCTTAGAACATATTCAGCAGTATCATGATCTCGTGCAGGAGAGGTTAAACACATTAGAGGCTCAAGTAACAGACCTGGAAAATATGCAGGACGACGCAGGACAAGATGAGACACCGGATAGCTGTCCTCGAACTTCAGCCACGATCAAGATGCTTCTCCGTGATCTGGATACTGTCAAGAGAGTGGCTACATTACCTTGA
Protein Sequence
MSKSGDKYSQQEDTQDSLGDDSFSADKSNFVIGAKLEATDASGVWYAARVENVNWEEREVLVHFERWSCKFDEWIPMCSNRLRSIQKPLPPKPPPRFERGQQVIAVWSAYNRCPATVQRALPDGKYEVLFEDGFVKRLLPSKMWHLDDVVSSPRSPAEASIGSKQDRRDRKRKLVVSELFRSNKKVKTDPNDKKTVAVASTSSAVDVTHMEAPAPPPGRKSLPPIAHAPPKPIEVRHLDGRKETWLKMLTRRSEGKTAGKLEIVICSASGRKFRSRADIIRYCEENKILYEPTLFDFSAKGRSKAKSIVQGSNEVADEEVVAPVAPPVAPDPPVIPMTAPLTTPEPVEEERRFIGDLEVIVQDGQFICPVTDCRKHFRRENLLHMHMKHYHPELSKYLDYTPSVTDLAYARTVSLEQQEGSPTVRPSLRSDIRCPDVKRSPVRIRDCRVEMNKVTLSTAVDATPPATIPEPAEDATTTDPEPIQPIQPPSLAEVGASVAPHEAVTESERDGVGGTEGDLEAVIPASVLQRPKIHWKRRPYHRHQLPLTDWYGRMGKQAAAGGAASEASGKQKDEESGDLVQRNPILNTLLSSRPLAPTLGWRPGWRRRRRGGWNKRRPPRTLPPALDQGPTPLAELTDGLEDSKPSPGADGSDLSKSPGPADGEKYEKLRGNEIINCTCQMKEEDGLMIQCDVCQCWQHGHCLGIAPQGEVPESYVCSVCKDPPKGRSSRKYYNHQDWLKQGVLPTLPFKPKSPSTQRQNLLKRAFEMSGQLSLLSRLLHSLRVKLNVAGNKDHPKLWLWARRWQEAHKPSHPLPTVKEEEPSMPKAPEPEKPIDPVECKMNLLEHIQQYHDLVQERLNTLEAQVTDLENMQDDAGQDETPDSCPRTSATIKMLLRDLDTVKRVATLP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-