Basic Information

Gene Symbol
MBD2_1
Assembly
GCA_950004255.1
Location
OX465374.1:8508505-8516878[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 6.3e-16 2.9e-12 46.1 0.1 5 71 1430 1494 1426 1500 0.91
2 3 8e-20 3.6e-16 58.6 0.0 11 72 1551 1610 1545 1614 0.93
3 3 1e-15 4.8e-12 45.4 0.1 9 70 1643 1702 1638 1706 0.96

Sequence Information

Coding Sequence
ATGGACAACGACGGCGCGGAGCAAGGTGCATCGGTTTGTCGCCGGCAGTCCGAGTTGGACTTCACGCCCTCCGTTGCGCTGCAAGGCCGCAACGTCATGTGCACCTCCACCATGATCAAGGTCACCTACAATAAACCCGTTAGCGAATCGCCAAGCCGCTGTGTGGAGAGGTTAGCTGCTGCATTTTGCCCCAGAGGCGCTACAAGTGTGATCCCATTGCCCCAGCAACCCGCACATAGCGTGGAAAGGGCTCCTCCCCCCAACAAACCCATTGCCATTCTTGTGTCCAGGGAGACTCCTTGTAAGGCCCTTCCGCAGGCACGGCCAGTTCATTACTATCCTTTCATGCTTACCGGGTCTCAGTCACTGAGCCAACATAACATTTCTTCAAACAAGGAAAATGTTGAAAGTGATGGTGGGGAACAGTTGGAAAATTTGGAGAATGATGGTAGGAAGCAGAAAGGGAAAGCTAAACGTGGCCATAAGAAGCAGTGGATTGAGGATAATGAAGCGATTGAAAAATATCGTAAGAAGAGGGGGCGCAGGTCCCGGAGAGGCGAAGCCTTGCCGCCCGAAGAAAGCATTATTGTACAGAAAGAATCCGCACGTAGATATGGGCGGAAGAGAAAAAGTAAGTCTGAAATCATTTTGGATGAGGCGATAGGGATTACGGAAGACAAATCAAAACGGAAGGTCCGATTGCTGCCGAAAGAGCttcctgaaattgaaacaaAGTCTAAACGAAAAACCGCTGTTGAGCTTGCTGTATCCGATTTAAAGCGCGTTCAGAAGAAACGCAAGACTACAATGAAAGATTCAACCGGAAAAGCGCATGATAGCTTCGCCTTTATTCCTCGAAGATCAGGGAGGATGAGGACTGCCATTAGATTTCATGATCTGGAGAGTGAAGCTGAAGATGCATATGAATGTAATGCCAAAGTTCCGTCTCGTGCAGCGTTATCAGAAACTAGGCGTAAATCAGTCCAGTCCCCTTGGCAAGGTGTACTGGCGAAAGCTGTTGATATATGTGAAAGGCTGCATAAAGAGTCGCTCGATGAGGAAGAGACAGCCGGTGTCGTTACTCGAAAGTCAAAACGTGGGAAGAAACGATCACGGACCGAAGATGAAGTGACACCAGTCGCACGCGAGAAGAGTACTGAATATGACTCAGAAAAATCAAAGGAGCGTGGGCGACGCAGCAGACGCCATCGACGTCACCATCACAAAGATAAAACTCTCATTCCCGAAGAAGGAGTAGTTGACTTTTGTGAACGCCcacgaaaaagaaagaaaaggcaTGAGGAATCACCTGGCCCTCCTGTTGCTGAAGGTACAAGCACACGTTTTCAAGCCAAGTCAGATTCACCAGTTGATGTCCAGCCCATGGCCTTCAACACAGAAACTCCTGAATCTCTTTCTGCAAAAGGGCGTAAAAAACGTGTACTCCGGTCTAAGGACCGTAAAGAACAGATAGTTGAAGAATCTAATGCCGGTGTCGATTCCGTTAGAACAAGTCGGCGACTCCGTGCTGccaaaaatcccaaaaacTCTGTTGACGAACCAAGCCCAAAAAGACGAGGGCGGCCGCCGAAATTGGTGAAGGAGGTAGACTCCAGGAATGTTGATGACCATAGCGTCCCTGTGGATCCTTTACTTGAAGCTTTGGCTCAGTATCTCAGCCGAGATAGTCCTATAACGCGGGGAAAGTCTAAAAGTCTCTCGAAGAATATGCAGCAATTACCTCCGGACTTGGGTCCCCCTCAAAATATTCCAGTTGGCGAAGAATATCGGAAAAAACACGACCAgtctgaaaatatttctggaAAGAAGGTACGGGCAAGGCGAGGTGAGGCTTTGAAAGAGCAGTCAACGTCTGTGGGCGACTCACCTTTACATAGCAGCCAGTTAAGCAGGAGATGGGAGGAAAAGGAGCTGGCTCCTGTAAAAGACGTAGTTAACCAATTGGATGTGTGTGAAGAAAACTCGATGGACGACCCCCTGGTTGCACAGATGGCTCAGCTAGAAAGGGAGTCTGTCATTAAACCTAATTTTGACGTAATAGTCCCTGTGCAAAGTATGACCTCTGGGTTATGTTTGCCGATCAATGCTACATTGTCAGAATCTGTAACAGCCAGGACATCTCAGACAGCGGGATCAGAAGCACCTCAGCCTTTGGTTTCTGCCATTTGTCCATCTTTGAATGCTGAGTTACCTCAGCAAAAGGTAACAGAGATAACTTTACCGTTGACTTCTGAGCGGCTTCCCCCCACATCTCAGACTGTTGGTGCCGAACCAAAACCagatgaaaattttccaacagGTACTGTAAGTGTTAAATTTGTGCCAGAAACAGTGGGAGCTAAAGAATTACCAGTTGGGACGAATTTGGAATTACAAGCATTAAATAACGAGCAATATTTGTCTCTGGATAATATGCCTCATGTTAGAGAGCAAACTCCAGATGTTGTGGCTTTAGATCCATTGGAAAAGTCCACACCGCCCAAGAAAAGAGGGAGGAGGAAACTACTTTCGATTCCTTACCAAAGAATCATTGAAAAGACTGAAATTCATATTCCTGCGGAAGTAGTGAAAGATTTTGGTATCCCCCCGGCACTTGATACACACGTTGCTGGGAATACTGAGCCGGTGTGTGTCGAACCACCCACATACGCCGTTGTGAAGGAAATAGCTGAGCCTATGGGAATTATGAATAGTCGAGGGTTGGGCCTGAgagaaaaggggaaaaatttCAGGCTTGTTGACAATAGAGAAAATTCAGAAGTAAACTCAGAAGACTTAGGGGTGGATACTGTCGTAATGGATTTTAACACTGTCATGTTCGATCCCGTCATGGTGGTGGCGGGTGAAGAAGTTGTTGAAGCACCGCCCGTAATAGATCTCACTGTCACTGAGAAACCTTTGGATTCTGTGACGGAGGAGCAGGTTATAGTTCAAAATCCAGACGTGTTAGGAGATCCTGAAAACACTCAAGATGAAAAGGCGGAAGTGTGTGAAATTGGAGGTGGCATCCGTgaagttgaaaaatttctagGTGAAGGTATTGAAGTGGGTGAAATTCGAGAAGTTGAAGGGGTTCGAGTTGAGGATCTTGAAGTGGGTGCAATTCGAGAAGTTGAAGTTCGGGGTGAAGATCAACAAGATATTTTGGAAGCACATTACAGCAATCTTCCTCCAGAAATTATTGATGAAAATGGACTGAGTGGAAAGAAACCaaagaaggagaagaaaaagaagaaaaaacaaaaaaaacataagCGAGCAAAGTCCACTGAACCCGAGAAATTTGAATGGGCCCCACTCAAAGTGAAAAATGGAAGTACATACATTGGTATGAAGGATAGACGTCAGTTGGTTGTCTCACTGGAGAAGCTGGATCCACCCAAGTTGGACTGCGAAAAACCGCAAGTGCTGGACAAATCGGACAGCGGTCGCAGGAAGTCGCCAAAGAAGTACAATCAACTTCGGAAAAAGCCCAAACCAGCGCTGGAGAGAGAGAATTGCATGTCTGGAGATGAAAAGGAGAAGCCAAAAATAGTAGTTCAGGAAGAGAAGTTAAAAGACAAGTCTGAAAAAGAGAAATTAACGACGAATGTGCAAGACGAGCTGGAGAAGTTGGCTTCGATGACCCTAACAATGAAAGAAAACCATTCTAGGGTGAAAATACGCTCCTCTCGTCATTGTAATGAACAAAAAGTTGTGGCCACCAAATCTTCCGGACCGTCGCACACTCAGAAACGTTCAAAACGATTGGAACATCCCAGTGACACTCTTGTAAAGAAGAAATACGCTCAAGGTGAAAAACCTTCTGTTGAAAAAAAGCACAGACATAAGACGCCTGAAAAAGAGGCTCCGAAACAGGTAATTCAAGAGGCTGAGCCTCCCGTGGATGTAAGTCCTATCGGAACTTCGGTGGTTGCCGACCGACCTAAGTCTATCGATGAAAAGCCACGTACACCCAAGTCTGAACAACCAAACAACAGCCTTCCTGTATTAAGGCCCAAAACTCCTAAACCAGAGCCCTTCGGACTGAAATCGCCTCGTGATAGGTCTGTGGTAGCAGCTTCAGCCACGCCGCAGTTGGCAAAAGACAGTAAAGGCGTGCGCATTGTACAGTGTGTAGATATGTTTAGTGGTCTGACGAAGCCGCAGGTGCGCAAAGAGCGGAAGGAGGCGAAGGCGGTAGCGAAGAGGCCGCACGTCGTGGTGCCCTCGCTGTTCGCCCCGGACCCGCCCGCGCCAGCGACTCGCCCTTCTCGCCCTAGTAACGAGGTGGCGggccccccactccccccTGGCTGGACCAGGCTAGTTCACACGCGGTGCAGTGGTGCTACCAAGGGAAAGCGGTCCATTGTCCTCTTAAGTCCTAATGGAAAACGATTTGATCGTAAATCTGAGCTGGAAAAATACCTCAAGAAACAGCGCCTTCCATACGAAGAAAATCAATTTAGTTTTAGTGTTAATTTTTCATCTCCCAAAACGTCGGTCAAATTTAAGAGTAAAAAGTCCATAACGACGAGCAAGAATGTAAGCAAAAATATGAAGACGAAGAAACAGCTAAGAAATAAGTTGGCAAGTGTTGGAGTTACGGCAGCTATGAGTTCGGAACAACTTAAAGCGGTTTGTGAGCTTCCTGGAGGATGGAAACGAGTGACACGCGTGCGCATCAACGGTCGATCAGCTGGGAGATCAGACACCCTATACTACTCACCCGAAGGACGGCGGCTGCGTAGTCGACCTGAGTTGGCAAAGTACCTACAGGACACAGGCTCCTCCCTGAAAGTGGAGGATTTCTTTACGGAAGATCCGTCTTCTGTCCGTCTTTCCAAACCGGTGCGTCAAGAGGCGACTGGTCCCTGCTCGACGGAGAACGCGGACCCTCatCCGGAAATACTGAGCGAAGGCCCAAGGCTTCCCGTTGGATGGAAAAGGGAGATACATGTGCGCAAAGGTGGGGATAGCCATGGCCGTGTCGAAGTGTACATGATAAGTCCTGACGGGAGGAAACTGTCCAGTAGAAAAAAGCTCCAGCGATACTTCCAACTCCGCAACCTTCCTTATAACCCTGAAGATTTCGACTTTTCACATTCTGGTAGAGGTAAAATAGAACGGGATACTCGGAGTGAAAATATTCCGAAACCAGCCGTCCCACCCCGTTCGCCGGTTAAAACGTCCATAAAAAAGATGGAGAAATTGAAACCTTCGTCTgagaaaattaagaaaaagagTGAGGGGAAGTCAGTTGAAAGCAGGAATGAAGAGAGGGAGGTTTTGAAGAGTGATGCGGAGATAAAGTCACGAGTGTTGACAAGAGATGAGCTGGTGGAGCTATATCGGAGAGTGCGCGATGACGCTGAGCTAGGTGTGGAGCTGACTCCTTGTGCTGATGGCTGCGTATCATCACCCCCTGACCTGTCCCTACCAGATCGCGTTCGAGCGATCGTGGTTGCGACCGGTTTGTCCTCTGCGCGGACTGAGCGGCGGCTTGCTGTCCTGCATGCGAGCGCTATGTGCAGCGTGCGATTCAGTGATGACCTCAGTGTGGAAACCACGATAGGAGTCCCTCCTCGATGGGTGCACAGCCTACTTCGCTGCCGGCCGGAACTGGCGGGTTTCGATGACTCTGCGATTGAGAGCGTTGCTGCAGCCACCGAGTACTTCATCCAGCGACTGGCGAGCCATGCGCACCGCCTGGGTGGGGAGGGCTCTCTGGAGTACCGTCATGTTGCGGAGCTAGTGGCCGACACGCCCAGCCTGGCGCCGCTAAGACCTCTCATCCCGCGCCGCGTCACTGCCACCCACTTTCGCCGACTTGCGCGCCCCTCCAGGTTCTTCTCTTTTACGGCGTAA
Protein Sequence
MDNDGAEQGASVCRRQSELDFTPSVALQGRNVMCTSTMIKVTYNKPVSESPSRCVERLAAAFCPRGATSVIPLPQQPAHSVERAPPPNKPIAILVSRETPCKALPQARPVHYYPFMLTGSQSLSQHNISSNKENVESDGGEQLENLENDGRKQKGKAKRGHKKQWIEDNEAIEKYRKKRGRRSRRGEALPPEESIIVQKESARRYGRKRKSKSEIILDEAIGITEDKSKRKVRLLPKELPEIETKSKRKTAVELAVSDLKRVQKKRKTTMKDSTGKAHDSFAFIPRRSGRMRTAIRFHDLESEAEDAYECNAKVPSRAALSETRRKSVQSPWQGVLAKAVDICERLHKESLDEEETAGVVTRKSKRGKKRSRTEDEVTPVAREKSTEYDSEKSKERGRRSRRHRRHHHKDKTLIPEEGVVDFCERPRKRKKRHEESPGPPVAEGTSTRFQAKSDSPVDVQPMAFNTETPESLSAKGRKKRVLRSKDRKEQIVEESNAGVDSVRTSRRLRAAKNPKNSVDEPSPKRRGRPPKLVKEVDSRNVDDHSVPVDPLLEALAQYLSRDSPITRGKSKSLSKNMQQLPPDLGPPQNIPVGEEYRKKHDQSENISGKKVRARRGEALKEQSTSVGDSPLHSSQLSRRWEEKELAPVKDVVNQLDVCEENSMDDPLVAQMAQLERESVIKPNFDVIVPVQSMTSGLCLPINATLSESVTARTSQTAGSEAPQPLVSAICPSLNAELPQQKVTEITLPLTSERLPPTSQTVGAEPKPDENFPTGTVSVKFVPETVGAKELPVGTNLELQALNNEQYLSLDNMPHVREQTPDVVALDPLEKSTPPKKRGRRKLLSIPYQRIIEKTEIHIPAEVVKDFGIPPALDTHVAGNTEPVCVEPPTYAVVKEIAEPMGIMNSRGLGLREKGKNFRLVDNRENSEVNSEDLGVDTVVMDFNTVMFDPVMVVAGEEVVEAPPVIDLTVTEKPLDSVTEEQVIVQNPDVLGDPENTQDEKAEVCEIGGGIREVEKFLGEGIEVGEIREVEGVRVEDLEVGAIREVEVRGEDQQDILEAHYSNLPPEIIDENGLSGKKPKKEKKKKKKQKKHKRAKSTEPEKFEWAPLKVKNGSTYIGMKDRRQLVVSLEKLDPPKLDCEKPQVLDKSDSGRRKSPKKYNQLRKKPKPALERENCMSGDEKEKPKIVVQEEKLKDKSEKEKLTTNVQDELEKLASMTLTMKENHSRVKIRSSRHCNEQKVVATKSSGPSHTQKRSKRLEHPSDTLVKKKYAQGEKPSVEKKHRHKTPEKEAPKQVIQEAEPPVDVSPIGTSVVADRPKSIDEKPRTPKSEQPNNSLPVLRPKTPKPEPFGLKSPRDRSVVAASATPQLAKDSKGVRIVQCVDMFSGLTKPQVRKERKEAKAVAKRPHVVVPSLFAPDPPAPATRPSRPSNEVAGPPLPPGWTRLVHTRCSGATKGKRSIVLLSPNGKRFDRKSELEKYLKKQRLPYEENQFSFSVNFSSPKTSVKFKSKKSITTSKNVSKNMKTKKQLRNKLASVGVTAAMSSEQLKAVCELPGGWKRVTRVRINGRSAGRSDTLYYSPEGRRLRSRPELAKYLQDTGSSLKVEDFFTEDPSSVRLSKPVRQEATGPCSTENADPHPEILSEGPRLPVGWKREIHVRKGGDSHGRVEVYMISPDGRKLSSRKKLQRYFQLRNLPYNPEDFDFSHSGRGKIERDTRSENIPKPAVPPRSPVKTSIKKMEKLKPSSEKIKKKSEGKSVESRNEEREVLKSDAEIKSRVLTRDELVELYRRVRDDAELGVELTPCADGCVSSPPDLSLPDRVRAIVVATGLSSARTERRLAVLHASAMCSVRFSDDLSVETTIGVPPRWVHSLLRCRPELAGFDDSAIESVAAATEYFIQRLASHAHRLGGEGSLEYRHVAELVADTPSLAPLRPLIPRRVTATHFRRLARPSRFFSFTA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-