Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 8.4 2.1e+04 -2.7 0.1 16 35 7 26 3 31 0.72

2 3 1e-40 2.6e-37 128.4 0.3 1 88 39 125 39 125 0.97

3 3 7.4 1.9e+04 -2.5 0.1 37 47 167 177 156 179 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	8.4	2.1e+04	-2.7	0.1	16	35	7	26	3	31	0.72
2	3	1e-40	2.6e-37	128.4	0.3	1	88	39	125	39	125	0.97
3	3	7.4	1.9e+04	-2.5	0.1	37	47	167	177	156	179	0.77

Coding Sequence: ATGCATAACTCAATAGTAAGTGAGTCGACGGAGAAGTGTTCCGAACTGAAATATGCATATGAGACAATCAAAGAAGAAAAATCTGCCTCGCAAATAATAAACGATATAAGTACTTCAAAACCACCCTACAGCTACGTTGCGCTTATTGCCATGGCGATTCAGAATTCACCTCTAAAACGTGCCACACTTAATGAAATTTACAGTTACATTACAACGcgatttccatatttcgaacaGAATAAAAAGGGTTGGCAAAACTCCATACGTCACAATTTAAGTTTGAACGAATGTTTCGTTAAAATGCCACGTGAGGGTACAGGTGAACGAAAGGGAAATTATTGGTCATTAGATGCGCACTACGAAAATATGTTTGAGAATGGTAACTAccgtagaagaagaagaatgaaaCGACCACATCGTACCGTGGGACATTTTCCTAAGTTGCTGACAGATGCCTGCCCTacgaaattgattttcaatcACCACACACCTTGCCAAACATATTACAGATATAACACAAATACTCAATGGATACACACGCAACCACTGTCTAATTATGGGCCGACTTCAGGGAGAGGTACTTTTCCGAATAACACAGCGACTAGTTTTTCCCCGCCTTTATTTGGAGCGAACACTTATAACGGCATTATAAATACTGAGGGAATTCCCGGCGGCGGCACAAAACTGATGGAACCATGTCCGTGTCCCATTTGGAATACAAGTAAGAAATTAATTGGGTTCGTTCGTATCTGCAGTATATTTGTGCAACACTTTGAAGAATTTTGCCTAAAAACTCATTTGGATGTACATGTCCTAGGCTATCAATCTAGTATTGTCTTAACTGTTTAG
Protein Sequence: MHNSIVSESTEKCSELKYAYETIKEEKSASQIINDISTSKPPYSYVALIAMAIQNSPLKRATLNEIYSYITTRFPYFEQNKKGWQNSIRHNLSLNECFVKMPREGTGERKGNYWSLDAHYENMFENGNYRRRRRMKRPHRTVGHFPKLLTDACPTKLIFNHHTPCQTYYRYNTNTQWIHTQPLSNYGPTSGRGTFPNNTATSFSPPLFGANTYNGIINTEGIPGGGTKLMEPCPCPIWNTSKKLIGFVRICSIFVQHFEEFCLKTHLDVHVLGYQSSIVLTV

Sequence clustering based on sequence similarity using MMseqs2