Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 10 5.4e+04 -4.3 0.2 59 64 67 72 63 74 0.59

2 3 10 5.4e+04 -4.6 0.6 38 43 87 92 84 95 0.38

3 3 1.8e-10 9.8e-07 30.4 2.6 2 38 272 308 271 309 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	10	5.4e+04	-4.3	0.2	59	64	67	72	63	74	0.59
2	3	10	5.4e+04	-4.6	0.6	38	43	87	92	84	95	0.38
3	3	1.8e-10	9.8e-07	30.4	2.6	2	38	272	308	271	309	0.91

Coding Sequence: ATGAGTAATCCGCCACCGTATTCCCAATCACCTCAACCAGGTTGGATTCCGGCACAGACCTATCAACCTGGTCAGGCTGTGATTGTAACCGTGCCGTCGCGACCGCCAAATCCGCCAGTGGGCCCCGACCCAGTGTCATTCAATTCCCTCGGTCATACGTTCTTTTCGATCAAGTCCAAATTCGAAAATATGGAACGATGCTATACGTGCACAACGTATTATCAGAATCCCAACTACCAGGCAGATGAAAGTATCATCTGTTGTCGTAGTCTTTGTTCAGTGCCCTCTTCGAATTTATCAGACACAGAGGTACCGCGTGCAAAAAGTTTGCCATCCAATATATCTGAACGTTCATCAAAGAAGAAACGAGCAAAAGTTGCTCAGAAGTCGAATTACTCCGGAAAATCAGGAACACTATTTGCCACAAAATCAACGGCAACAGAATACTACAATGTCGGACCAGTACCGATGAGATGCCGTCGGTCAGCCTCGTCCGAAAGCTCTTCCGACAAATCGTTTTCCTCGTCAATGCGGGATAATTACGCGTCACCAGTCAGTACCTGGCCACCAACCAAACATTTGATGATTACATGTAAAGAGGGAACATTTGAGCGGTTGCCACAAACTGAACATATCTTAGATGCGAGTTCAAAAGATTCGCAAATGGATCCCAGAATTACGAGTACTAAGAAACGCTCGACTTCAAAATCATGTTTCTCTACGACAAAATCGAAAGATGCCCGACGGGATACTAATCGCATAAGGGCTAATGTTACAGAGCCGATACGTTCTATAATATACAATGTCGGCCCGCGTCCTACCGAAATGACGTGTCCCTTCTGTGGATATGAAATCAAAACCATCGTCAAGCATAAAGCAAACACCAAAACCCATGCCATAGCGATTTGTTTCTGCTTCACTATAATGTAA
Protein Sequence: MSNPPPYSQSPQPGWIPAQTYQPGQAVIVTVPSRPPNPPVGPDPVSFNSLGHTFFSIKSKFENMERCYTCTTYYQNPNYQADESIICCRSLCSVPSSNLSDTEVPRAKSLPSNISERSSKKKRAKVAQKSNYSGKSGTLFATKSTATEYYNVGPVPMRCRRSASSESSSDKSFSSSMRDNYASPVSTWPPTKHLMITCKEGTFERLPQTEHILDASSKDSQMDPRITSTKKRSTSKSCFSTTKSKDARRDTNRIRANVTEPIRSIIYNVGPRPTEMTCPFCGYEIKTIVKHKANTKTHAIAICFCFTIM

Sequence clustering based on sequence similarity using MMseqs2