Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.00067 3 7.6 0.5 25 47 149 170 142 174 0.89

2 4 0.0029 13 5.6 0.0 26 48 176 198 171 201 0.86

3 4 0.0013 5.9 6.7 0.1 22 49 231 258 224 262 0.88

4 4 8.1e-05 0.36 10.6 0.3 21 48 287 314 280 316 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.00067	3	7.6	0.5	25	47	149	170	142	174	0.89
2	4	0.0029	13	5.6	0.0	26	48	176	198	171	201	0.86
3	4	0.0013	5.9	6.7	0.1	22	49	231	258	224	262	0.88
4	4	8.1e-05	0.36	10.6	0.3	21	48	287	314	280	316	0.91

Coding Sequence: ATGAGTGAAAGGCCTTTGTATCAGTGTCGTTTATGTTTAACAAATTCAAAATTGTATTATTCACTACTCGATAAAGGTGTGAGTGGAATAATTGAAAGTTTCACACCAATTAAGATTAAAGATAATGATGGTTTATCAACATATTGCTGTTCAAACTGTTTAGAAGAAATCTATTTAGTTGATAAAATACGTTGCCGTATTGTCGAATCTGATCGAATTCTACGCGAAGAACAACAAAAACAAACACCTGCATTTAATCACGAGATTACTGAAAATAATGACAATAAACCTGTGATTGTTATAATTAAAAATGAAATATCCGATAATGTGAACTCATCAAAATTGGCAATAACTAATAACGATTCTACAATGAATCCTGTATTAAATCAAGCCGATGAACAGAGTTCATCTATGGAGAAATTAGAGAATGATCAAATTTTAATGACAACATGCGAAATATGTTTTCGACAAATACAAATAAAAAATTACCAACGACATATGTCTTTGCATAATTCAACACAACAAATTTGTGAATTGTGTGGTGCTATTGCAAAAAATTCGGAAAGTCTACGTGGCCATATGTTCTATATGCATAAATGTACAGCTGAAGAATACAAATGTGATCAATGCGGTAAATTCTATCGTTATAAATATAAATTTTTATTGCATATGAGGAAGGCGCACGGTGGTGAACGGACGCATATTTGTGAAATTTGCGGTAAATCATTTTATACAGGACGTGATGTTAATCGTCATATACAAATGAAACATTTAAAATTACGTCCATATAAATGTCAGTATTGTAATAAGAATTTTTGTAGTACATCAGCATTACAAACACATATAAGACAACATACCAATGAGAAACCATATAAATGTGATGTGTGTTCGGAGTGTTTTCGACAAAAGATCTCGTTAAAAACACATCTAAAATCAAAACATGCTGTTATATTAAATACAAATGAGAATAATTAA
Protein Sequence: MSERPLYQCRLCLTNSKLYYSLLDKGVSGIIESFTPIKIKDNDGLSTYCCSNCLEEIYLVDKIRCRIVESDRILREEQQKQTPAFNHEITENNDNKPVIVIIKNEISDNVNSSKLAITNNDSTMNPVLNQADEQSSSMEKLENDQILMTTCEICFRQIQIKNYQRHMSLHNSTQQICELCGAIAKNSESLRGHMFYMHKCTAEEYKCDQCGKFYRYKYKFLLHMRKAHGGERTHICEICGKSFYTGRDVNRHIQMKHLKLRPYKCQYCNKNFCSTSALQTHIRQHTNEKPYKCDVCSECFRQKISLKTHLKSKHAVILNTNENN

Sequence clustering based on sequence similarity using MMseqs2