Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.6e-40 4.1e-37 127.0 0.1 1 88 12 98 12 98 0.97

2 3 3.3 5.1e+03 -1.6 0.0 35 66 108 138 106 147 0.72

3 3 0.16 2.5e+02 2.6 0.0 45 61 208 224 200 241 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.6e-40	4.1e-37	127.0	0.1	1	88	12	98	12	98	0.97
2	3	3.3	5.1e+03	-1.6	0.0	35	66	108	138	106	147	0.72
3	3	0.16	2.5e+02	2.6	0.0	45	61	208	224	200	241	0.87

Coding Sequence: ATGCCGCGGCCGTCGCGCGATTCCTACAGCGATCAGAAGCCACCCTACTCGTACATATCTCTTACTGCCATGGCGATATGGAGCTCGCCGGAACGGATGCTGACGTTGTCTGAGATATACAGGTTCATCACTGATCGGTTCCCTTATTACCGATACAATACGCAGCGCTGGCAGAACTCGTTGCGACACAATCTCTCCTTCAACGACTGCTTTGTGAAAGTGCCTCGGAATCCTGACCGACCTGGAAAAGGAGCGTATTGGACCCTGCATCCACAAGCCTTTGATATGTTCGAGAATGGTTCGCTGCTTCGCCGTCGTAAGCGCTTTACGTTACACAAAAGAGAGAAGGGCAACTTGAAGACTGAATTGGCAGCGTTATTAAGTTTTAATCATCAATTTCTAGCGTGTCAGAATGAAATACCAACGACTCAATTAAAGGACTTAGCAAAGTATAAGGATTCTTCAAAATGCAGTGCTGAAAGTAAGCCCCGAAAATCTTTTACTATAGACAGTATACTAAGAAGTGATATTGGAACGGAAAGTAGTGGTGTTAATAGCGTTCAAAGTTCAAGCGGTAGTGCTACCACTGTTTACCCACCAGACTTGATGGCTATTGCTGCTATGGTATGGCAGTCTTCTGTATCTTATCAGTTAACTATGTACGCTCCATTTAATATTCCATTTCAAGATTACAGTGATTTGCAAAAACTATTTTACATCCAGTTATTGCAGCAACAGTAA
Protein Sequence: MPRPSRDSYSDQKPPYSYISLTAMAIWSSPERMLTLSEIYRFITDRFPYYRYNTQRWQNSLRHNLSFNDCFVKVPRNPDRPGKGAYWTLHPQAFDMFENGSLLRRRKRFTLHKREKGNLKTELAALLSFNHQFLACQNEIPTTQLKDLAKYKDSSKCSAESKPRKSFTIDSILRSDIGTESSGVNSVQSSSGSATTVYPPDLMAIAAMVWQSSVSYQLTMYAPFNIPFQDYSDLQKLFYIQLLQQQ

Sequence clustering based on sequence similarity using MMseqs2