Basic Information

Gene Symbol
Aef1
Assembly
GCA_963668005.1
Location
OY764962.1:102744653-102745754[-]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0029 40 5.1 0.1 19 48 172 201 167 205 0.85
2 4 6e-06 0.084 13.6 0.0 21 51 202 232 199 233 0.88
3 4 0.0026 37 5.2 0.0 21 51 230 260 228 261 0.87
4 4 8.6e-05 1.2 9.9 0.1 21 47 258 284 255 291 0.88

Sequence Information

Coding Sequence
ATGCACATCAAGAATCTGCAGCATGCCCACGCGTCCGCGGCGATGGCCAACTGCGAGATTGTGATTGTGGCTTCGTCGCCCAATAACAGCGCtccgaacaataacaacaacaacaatagtactaacaacaatgacagcacaAACAGATCGcaccaccagcaacagcagcaacagcaacagcagcagcaacaacaacaacaacaacaccagcccCAAGCTACTGTTACCGAAATTCCGATTCCCTTCAACATGCACCTGGCTGCCGCCAATTCGGAGGCGCACGCTGCCGCTCAGGCAGCCGCCATGGCTGCAGCGCAAGCAGCCGCCGCGCAGGCCGCTGCTGCTGAGCAGCAGCAGTCTGGTGCTACTACCGGTGGCGGTACGGGTCATACCATTTTGCAGCAACACTCGTTGGCCCATTTGGTGGCTACGGCGGCCAATAGTCCAGCCTTGTCGGAGCAGCACTACATCGGGCGCGACGTGGTGGCCAACGGGCACAATGAAAGCGCGCCCAGTGGACCGGAGAAACCCTTCCTGTGTAACGTGTGCGAGCGGCGGTTTCGGCAGCTAAGTACACTTACTAACCACGTCAAGATCCACACCGGCGAGAAACCGTACAAATGCAACATTTGTGATAAGACCTTCCGTCAATCGTCCACGCTCACGAATCACCTAAAAATACACACTGGCGAGAAGCCGTTCGCCTGCACCTATTGTCCTAAGAACTTTCGGCAGCTGAGCACCCTGACGAACCATTTGAAGATCCACACAGGTGAAAAACCGTTCGAGTGCGCCGTGTGTAAGAAGCAGTTCCGGCAGTCTAGCACGCTGAACAACCACATAAAGATCCATGTCATGGACAAGGTGTACGTGCCCGTGAAGATAAAGACCGAAGAGGAGGAGGGATGA
Protein Sequence
MHIKNLQHAHASAAMANCEIVIVASSPNNSAPNNNNNNNSTNNNDSTNRSHHQQQQQQQQQQQQQQQQHQPQATVTEIPIPFNMHLAAANSEAHAAAQAAAMAAAQAAAAQAAAAEQQQSGATTGGGTGHTILQQHSLAHLVATAANSPALSEQHYIGRDVVANGHNESAPSGPEKPFLCNVCERRFRQLSTLTNHVKIHTGEKPYKCNICDKTFRQSSTLTNHLKIHTGEKPFACTYCPKNFRQLSTLTNHLKIHTGEKPFECAVCKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEEEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01133176;
90% Identity
iTF_00979589;
80% Identity
iTF_00979589;