Mcra005048.1
Basic Information
- Insect
- Melieria crassipennis
- Gene Symbol
- Poxm
- Assembly
- GCA_963668005.1
- Location
- OY764961.1:80241948-80242907[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 8.7e-55 2.7e-51 173.3 0.4 25 125 2 102 1 102 0.99
Sequence Information
- Coding Sequence
- ATGCGCATAGTTGAGTTGGCCCGACTGGGTATACGGCCTTGCGACATTTCGCGGCAGTTGCGCGTCAGCCACGGCTGTGTCTCGAAGATACTTGCGCGCTACCACGAAACCGGCTCTATTTTGCCCGGCGCGATTGGAGGTTCCAAGCCACGCGTCACCACGCCTAAAGTGGTCAACTACATACGCGAGCTGAAGCAGCGCGATCCGGGGATCTTCGCATGGGAGATACGAGACCGGCTGCTTAGCGAGGGCATCTGCGATAAAACAAACGTGCCCAGCGTCAGCTCCATATCGCGAATATTGCGCAACAAACTCGGCACGATCGGCCATCACCACCACAGCGGCGCTGTGGCGAACGGCACAAACACCTCGCCGCACCACCACCCACATCATCACGCCCACCACCACGCCTCACCGCACGCAACCAGCGTGTCGACAGCAGCAGCGCACCACACGCATGCTGCCGCCGTCCACGCGCACCCGCACCTTTACAATTCCATCTACCAGCCTTACAGCGCCTACAGCATGAAATCGGCGGTCTCCTGTGGCAGTCCGTCGCCCCCGCAGACAGCGCAAACGTCGCACCAACTGCGATCGGCTGCAGCCGCGGCAGCCGCTGCCCACTGCTGGCCCTCTTCGCACTCCGTCTCTGACATTCTGGCCCATCACCAGGCGGTCGCATTGCGAGCCAGCTGCCAAATGGGCAACACGGTCGGCGGCCTGCCGTCGGGCCTACCCATGGCACCCTCACCAGTTGGCGGCGCGGTCGGTGCAGGAGCACAGCAACTGCTTAGTGGCGACTGCGATGGAGCCACGGGCAACGCGACCGCCACACAGGTAGCTGTGGCGGCTGCGGCAGCCTCCCAGCAGCCGTACAACTACTATATGTATTTTCAAAACGGCGGcatgcaccaccaccaccacggCGGCATGATGACAGCGGGTGCGACGGGCTTATGA
- Protein Sequence
- MRIVELARLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISRILRNKLGTIGHHHHSGAVANGTNTSPHHHPHHHAHHHASPHATSVSTAAAHHTHAAAVHAHPHLYNSIYQPYSAYSMKSAVSCGSPSPPQTAQTSHQLRSAAAAAAAAHCWPSSHSVSDILAHHQAVALRASCQMGNTVGGLPSGLPMAPSPVGGAVGAGAQQLLSGDCDGATGNATATQVAVAAAAASQQPYNYYMYFQNGGMHHHHHGGMMTAGATGL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00081153; iTF_00082075; iTF_00082880; iTF_01055174; iTF_00972141; iTF_01486128; iTF_00189903; iTF_00190626; iTF_00193510; iTF_01562845; iTF_00192038; iTF_01563721; iTF_00191313; iTF_00192765; iTF_00303761; iTF_01045416; iTF_00091189; iTF_00797685; iTF_01189375; iTF_00992544; iTF_01357890;
- 90% Identity
- -
- 80% Identity
- -