Basic Information

Insect: Melanotus villosus
Gene Symbol: topi
Assembly: GCA_963082815.1
Location: OY720419.1:64971654-64981381[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0013 0.29 14.1 2.1 2 21 132 151 131 152 0.94

2 14 0.00012 0.027 17.3 0.9 1 23 177 199 177 199 0.91

3 14 0.013 2.9 10.9 2.0 2 23 206 227 206 227 0.95

4 14 0.6 1.4e+02 5.7 0.0 2 19 246 263 245 266 0.89

5 14 1.6e-05 0.0035 20.1 1.1 2 23 342 363 341 363 0.97

6 14 2.2 5e+02 3.9 0.1 1 22 369 390 369 390 0.90

7 14 0.14 33 7.6 2.7 2 21 406 425 405 429 0.83

8 14 0.0025 0.56 13.2 0.6 1 23 553 576 553 576 0.97

9 14 0.012 2.7 11.0 0.1 1 23 580 602 580 602 0.97

10 14 1.1e-06 0.00024 23.8 2.4 1 23 608 630 608 630 0.98

11 14 0.038 8.6 9.5 0.2 1 23 636 661 636 661 0.96

12 14 0.64 1.4e+02 5.6 2.5 1 23 667 689 667 689 0.85

13 14 3.1e-05 0.007 19.2 0.3 3 23 697 717 695 717 0.98

14 14 4.7e-06 0.0011 21.8 0.5 1 23 723 746 723 746 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0013	0.29	14.1	2.1	2	21	132	151	131	152	0.94
2	14	0.00012	0.027	17.3	0.9	1	23	177	199	177	199	0.91
3	14	0.013	2.9	10.9	2.0	2	23	206	227	206	227	0.95
4	14	0.6	1.4e+02	5.7	0.0	2	19	246	263	245	266	0.89
5	14	1.6e-05	0.0035	20.1	1.1	2	23	342	363	341	363	0.97
6	14	2.2	5e+02	3.9	0.1	1	22	369	390	369	390	0.90
7	14	0.14	33	7.6	2.7	2	21	406	425	405	429	0.83
8	14	0.0025	0.56	13.2	0.6	1	23	553	576	553	576	0.97
9	14	0.012	2.7	11.0	0.1	1	23	580	602	580	602	0.97
10	14	1.1e-06	0.00024	23.8	2.4	1	23	608	630	608	630	0.98
11	14	0.038	8.6	9.5	0.2	1	23	636	661	636	661	0.96
12	14	0.64	1.4e+02	5.6	2.5	1	23	667	689	667	689	0.85
13	14	3.1e-05	0.007	19.2	0.3	3	23	697	717	695	717	0.98
14	14	4.7e-06	0.0011	21.8	0.5	1	23	723	746	723	746	0.98

Sequence Information

Coding Sequence: ATGAACAGCtctaataatatatttcttACTGTACATCGGATTACTGAAGATGGAACAATAAGTTCGTATCAATATGAGGAAGATTTCATCACTCAGGAAGTGGTATCAAAAACCCCAATTTCTATTGGAaatctaaatttcaatttacattACGACTGGAATTATCCTACTgataataaagttaatttaagcTACCGCTATTTAGAACCTGATGATCATTCAGTTACAATAGTGAAAATTGGTGGAGTCGAAGACCTGAATCCAATGAATTATGTAACAGACATAACTACTGTCCTTGATGATTCTACAGATTGTAAACCCTATATTAATAATATCGTGTCTTTGGGAAAATCAAAACGTGAGAGCAAAATTCCTAATATACCAACGATGGTTCGATGTCAAAATTGTGACACTAACTTTCCAACTAAATATCAGTATCAGAGACACCAATGTGAATTTAATGCAGACAAAGTGGTGTTGAAGGCAGATGCGGACATCAAAGACATCGATAAAGGCATGAGAATCAAATATGACTGCATAACTTGTGGTAAGCAGtttgtaagtaaaaataatttagaaagacATCAAACCAGTCACGATAGTACCCAGGAAAATGTATGTGAACATTGTAATAAGCAATTTGTCAGTGAAAATCGACTTCGTATTCATAAAGAAAATCACTGTAAAAAAGCTGGTGATATTTCTAAGTTTTACCGCAGTGATGTCACTGTATGGAAATGTATTAAGTGTAATCAGGTATTTGCTACACCTGCATCAGCAAATCGACATGCTGAGAACTGCATGGATATAATGAACGATATTgctttggaagttaaaattgaagaaaattccCATACTTCTCAAGAAACTACTGAATTGAtgatgttagaagaagaaataaaaactttatctTCTGTTGCTCCAGAAATTATAAGCGAAGACGTTTGCAACGAGAATATAAGTAATTCTAAAACAGAGCCTATCACTTCAAATGTGGAAAAAGTATTGACAGAACTTTTGCTACAATGTGAATATTGTAATCGTACATACTCCGATAGAAATCTACTTTTGGCCCATCAGAAAAAGCATACAACGGAAGTTAACTATGAATGCATAACTTGCAAAGAAACATTTGATTCATATACTTCCGCTGCAAGACATTGGATGACCAAATGTTCCGATGAagctaatttattttacttaccgAAAATGACTTATTGTGAATACTGTGATCGTACATTCAAGTCTCATGAAATTCTTTATactcataaaattaaaaagaaacattataCTCCTAAACTACATATAACAAAAGATGATAACATTAGTATTAAAACACCACAAGCTGAAGAAAATAAAGATGTGTTGGTAAAACTAATTGAAGATGTACTGACTACAATGgatgtttcaataaaaaaagataaagagAAATCAGACAAGAACAAAGAAGATAAAGAAAGTACAAATCCAAATAAAAGTACTGATCAAGATGATGATGTGGTTGAAGTAAAAAATGAGAAATCAAAACCTGATGGAGAATCCCAAGATAAAGAAACTCAAgaacctgaaaagaaaaaaaggggCCGTAAGCGTAAGTGGCCTAAGGAGGCACCCAAAACTAAACGTATGGCATTTACTGTTGATGATGGTTATCAATACCAATGTGAACGCTGTGTACTCGTATTTGATACAATATCTGATCTAGAACATCATCGAGAGAAAGAGCATGCATCTAATTTTTCATGTGAAGAATGCGGACAAgTTGTGCATAGTGCTAAAGCATTGGTTATACATAGCAGAGCTCACCAAAGTTTAAAGCCTTATGTATGTGAGCAGTGTGGCCGCAGTTATTCACAAACTTCACATTTGTGGCAGCATATGCGTTTTCATCAAGGTattaaaccgtttgcctgtccTCATGAAGGTTGTGAAGCTCGTTATACGATTCGTCCAGATTTAAAGGATCATATTAGAAAAGTTCATACTCGTGAAAGGCCATTTAAATGTGCTGTATGCAATAAATGCTTTTTAACTGGTTCTGTTTATTACCAGCATCGTCTTATTCATACAAACGATCGTAGATACGGATGTGACATATGTGAAAAAAGATTCTTCCGTGCAGATGCTTTAAACAATCATCGCAGAATCCATACAGATGAACGTCCGTACCCTTGCGAAATATGCGGAAGAGAATTTAGACAAAAAGGGGATAGAAATAAACATGTACGTACACAGCATCcagaataa
Protein Sequence: MNSSNNIFLTVHRITEDGTISSYQYEEDFITQEVVSKTPISIGNLNFNLHYDWNYPTDNKVNLSYRYLEPDDHSVTIVKIGGVEDLNPMNYVTDITTVLDDSTDCKPYINNIVSLGKSKRESKIPNIPTMVRCQNCDTNFPTKYQYQRHQCEFNADKVVLKADADIKDIDKGMRIKYDCITCGKQFVSKNNLERHQTSHDSTQENVCEHCNKQFVSENRLRIHKENHCKKAGDISKFYRSDVTVWKCIKCNQVFATPASANRHAENCMDIMNDIALEVKIEENSHTSQETTELMMLEEEIKTLSSVAPEIISEDVCNENISNSKTEPITSNVEKVLTELLLQCEYCNRTYSDRNLLLAHQKKHTTEVNYECITCKETFDSYTSAARHWMTKCSDEANLFYLPKMTYCEYCDRTFKSHEILYTHKIKKKHYTPKLHITKDDNISIKTPQAEENKDVLVKLIEDVLTTMDVSIKKDKEKSDKNKEDKESTNPNKSTDQDDDVVEVKNEKSKPDGESQDKETQEPEKKKRGRKRKWPKEAPKTKRMAFTVDDGYQYQCERCVLVFDTISDLEHHREKEHASNFSCEECGQVVHSAKALVIHSRAHQSLKPYVCEQCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCAVCNKCFLTGSVYYQHRLIHTNDRRYGCDICEKRFFRADALNNHRRIHTDERPYPCEICGREFRQKGDRNKHVRTQHPE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01295424;
90% Identity: -
80% Identity: -