Basic Information

Insect: Megathymus ursus
Gene Symbol: Hr39
Assembly: GCA_003671415.1
Location: PDGT01000046.1:742671-757896[-]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 2 2.3e+04 -5.7 11.4 65 207 209 360 162 368 0.48

2 5 5.1e-08 0.00058 19.7 0.2 1 21 445 465 445 482 0.88

3 5 0.0018 21 4.7 0.1 76 117 487 535 467 544 0.62

4 5 2.2e-35 2.5e-31 109.8 0.0 210 317 548 650 540 652 0.95

5 5 9.9e-15 1.1e-10 41.8 0.0 337 408 649 726 648 726 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	2	2.3e+04	-5.7	11.4	65	207	209	360	162	368	0.48
2	5	5.1e-08	0.00058	19.7	0.2	1	21	445	465	445	482	0.88
3	5	0.0018	21	4.7	0.1	76	117	487	535	467	544	0.62
4	5	2.2e-35	2.5e-31	109.8	0.0	210	317	548	650	540	652	0.95
5	5	9.9e-15	1.1e-10	41.8	0.0	337	408	649	726	648	726	0.89

Sequence Information

Coding Sequence: ATGAACGCCGCGATGTCTAGCGAGGGAGAGGCGGTGAAGATTGAGGGTGGTCATGTGTCAGTTACTACCATCAGCATGGCTGGGCCGGAAGCCAGTaatgGTCAGTTCTCGTACAGCTCGAGCGGAGTACGCATCAGCGTGTCCTCGGAGCCTCACGACGAAGACTCCACTGACGCGGAAGTCTCCAAAATCGACTTTACGCAACACCAGTATGAGGTGAATATGCGTAACAAGAAGAAGCGCTCGTCCAGCGGACATTGCGATCAGAGTGAACAGGAGCGGCCCATGTCGTGGGAAGGCGAACTGTCCGACTCTGAGGAGATGGTCATAGATACCAACGCCAACAATGATGAAAACAGCAGCATGCTAGACCTGCAGTCGTCAAGGGACTCCATCGACACTCTTCGCAACGTGACGATCAAGACGGAGCCTTTGAAGAGCGAGGTCTTTCAGAGCTTGGATGACCAGAGGGTGCTCGACTTGAAATACGCCTCGCCGTTGCAGTCGCATCAGAGGAGTCTCAGTATGAACAGGATATCAGTGTTGACGGACAATGCGTCCCTCTCGCTGCCCCGCCGGCCGACCTCCCCGACGAACAGCGCCAAGTCGCTAGCGCTCTCCGACCAGTACGAGCAGCACTCGATGCCGTTGATGACGCAGAACTCCAACACCGAGATCCAGAATTTGACTATCAAAAAGGAAACGCAGTTGTCAGAATTAAAATGTGAGCCAGCTGTGGGCATGGATAAGTTACTAGGCCTCCATGGATCCCCACTGCTGGGGCGGCTGCCGCGGGTGCAGTCCAGTGCTAGTACGGATTCGGCCGTACATTCTATGTATACGCACAGCGTGTACAGCAGTCCGTCGGCGAGCCCGCGGCCGGCGCGCCACTACACGCCGTCGCTGTCGCGCAACAACAGCGACGCGTCGCACTCCTCCTGCTACTCGTACAGCTCCGAGTTCTCGCCCACGCACTCGCCGGTGCAGGGTCGGCATCCGCACGTGGTGTACAGGGAAGCGGCGGTGTTCCCCGCCTCGCCGGCACAGGAGGAGGACGCGGAGACGGCCGAGGAACGACTCCATCACCACCAGGGGATCAGTAGGCAGCAACTTATTAACAGCCCATGTCCGATCTGCGGGGACAAGATTAGCGGGTTTCATTACGGGATATTCTCGTGCGAGTCGTGCAAGGGGTTCTTCAAGAGGACGGTCCAGAACCGCAAAAATTACATGTGCCTGCGCGGGGGCAACTGTCCTGTGACGGTGGCCACTAGGAAGAAATGTCCGGCTTGTAGGTTCGACAAGTGTCTCGGCTGTGGGATGAAACTGGAAGCTATCCGCGAGGACCGCACGCGCGGCGGCCGCTCCACCTACCAGTGCTCGTACTCGCTGTCGGGCGCCGCGTCCACCGGCTCGCTGCTCTCGGCGCACGCGCACGCTCACGCACACGCCGCCACCTCGCTGCGGCACGCCACCAGCCTCACCTCGGTAAACGGTCCGACATCGTATAACAGTCGAGGGGAGTCCAGCAACAGCCGACTCACGCCTGACATACCACCGCTGTTACAGGAGATAATGGACGTGGAGCACCTGTGGCAGTACAACGAGTCGGAGCTGACGAGGCTGGGCAACGCCGACTTCCTGGCCGACCTGTGCAACATCGCCGACCACAGGCTGTACAAGATCGTCAAGTGGTGTAAGAGCTTGCCGCTCTTCAAAAACATCTCGATCGACGACCAGATCTGCCTGCTGATAAACAGCTGGTGCGAGCTGCTGGTGCTGTCGTGCTGCTACCGCGGCGTGGGCACGCCGGGCGAGGTGCGCGTGGGCGGCCCGCGCGGCATCACGCTGCACCAGAGCGCCAAGTACGGGCTGACGCCGTGCATAGAACGAATGCTGAGCTTCACGGACCACCTGCGGCGGCTGCGGGTCGACCGGTACGAATACGTGCGCGCGTCGCAGGAGAAGGCGCTGGCGGCGCTGCAGGCGTACACCGCGGCGCACTCGCCCGACGCGCCCGCCAAGTTCGGCGAGCTGCTGCTGCGCATCCCCGAGCTGCAGCGCACCTGCCAGTTCTTCATGCAAGTCGGCAAGGAGATGCTCAATCCAGCGAACAAGGGCAAAGACGGCGAAGGGCCGAGCTTCAACCTGCTCATGGAACTACTGAGAGGGGACCACTGA
Protein Sequence: MNAAMSSEGEAVKIEGGHVSVTTISMAGPEASNGQFSYSSSGVRISVSSEPHDEDSTDAEVSKIDFTQHQYEVNMRNKKKRSSSGHCDQSEQERPMSWEGELSDSEEMVIDTNANNDENSSMLDLQSSRDSIDTLRNVTIKTEPLKSEVFQSLDDQRVLDLKYASPLQSHQRSLSMNRISVLTDNASLSLPRRPTSPTNSAKSLALSDQYEQHSMPLMTQNSNTEIQNLTIKKETQLSELKCEPAVGMDKLLGLHGSPLLGRLPRVQSSASTDSAVHSMYTHSVYSSPSASPRPARHYTPSLSRNNSDASHSSCYSYSSEFSPTHSPVQGRHPHVVYREAAVFPASPAQEEDAETAEERLHHHQGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYMCLRGGNCPVTVATRKKCPACRFDKCLGCGMKLEAIREDRTRGGRSTYQCSYSLSGAASTGSLLSAHAHAHAHAATSLRHATSLTSVNGPTSYNSRGESSNSRLTPDIPPLLQEIMDVEHLWQYNESELTRLGNADFLADLCNIADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLVLSCCYRGVGTPGEVRVGGPRGITLHQSAKYGLTPCIERMLSFTDHLRRLRVDRYEYVRASQEKALAALQAYTAAHSPDAPAKFGELLLRIPELQRTCQFFMQVGKEMLNPANKGKDGEGPSFNLLMELLRGDH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00985246;
90% Identity: iTF_00971466;
80% Identity: iTF_00970506;