Basic Information

Gene Symbol
egg
Assembly
GCA_003671415.1
Location
PDGT01000002.1:973086-1000089[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5 6.7e+03 -2.9 0.0 28 38 1882 1909 1869 1910 0.64
2 2 1.8e-13 8.4e-10 38.5 0.0 4 75 1941 2005 1938 2007 0.89

Sequence Information

Coding Sequence
ATGAGTTCTAAAGACGTCGAGGGTATCATCATTTGTTACAACAAAGATACAAACCAATCACAGGATAAAAATTGTGAAGAGCTAGAAAAAGGTGACTTGTTAGAAAAACTAGGCAGTGTGGGACCGTCATGTACTAAACATGTTGACGAAAATAATGCGGAAAATACAGGCAGAGTAGTTATCAGCACAAATGGAAACAAAGGAAATCTCACAGACCAGATTAATTCTGAAATATCAATAGAGAATAAAGAAGCTGCTTCTCTGTGCAGTGTAGAGGAAGAATTTACAAGCGACATGCAGGAAGAGGAAATAAAATTGAGGTGGGATGATGATGAATATTCAGTGGAATTTGGGGAAAAAGTTGTTACCACTGATACAAGCAAAGACACTTGTCTTAATTCTGGAAAGGAAGCGATCAATAAAAATGAACTTTACCTACTAAAGAGGAGTAGCGCTATTGACAGTGGTAAAGAATTTATCCAAAATGCAGTAGTTACTGAGCTTATTTCAACCAAACCTCAAAGTGAGTCATTTGCAGAGGCTCCAGTTTTAAAAAGTGAGCATGGAATAAACCAACCAGATGTTATGTTAGAGATACCTGGTATGGGTATGCTACCAGATATGGACAAGGAGTTAGAAAGTATGGatgttgaaatgttttttgataCTGACAAAGATTTAAGCTCTGAAGATACAGACAAAAGCTTGTCAGAATTAGTTTCGAAAGCAAATGATGAAATAACTGAAACATTGTCTTCTCTGGAAGAAAGTGAAATGGATGGTAAATTGGAAATGTCTCCTGATAAAAGTGATGACACTCCTGCAGCTcctactattaataaaactacattAACAAATGCattcaaaattgaaatgaaattactaTCAGACACAACAATCTCTATTGCAGAAGAGACTGATCCTTCTGtagataaattaagtttaatggAAGCAGATAAAATGGAACTAAAATGTTTAGTTAAATCAATGTCCAACCAAGAGCAAGATGACACCTTTGACAATATACCTACTTCACTTACTAAACCTTCAACTgttatagaagaaaaaaatgtatttgaacttcaAGCTACCACAAGCGAGcagagagaaaaaaatatgaatctcAAAGTGTCCACCCTTATTAGTAGTATAGAAGAAGAAATGCAACTTTTAGACTCTAATGACGACATGGATATCTCTGAAAGAACTTCCGAaattaagaaacttaaaaaacCTGCCAAAATAGAAAGTATCATAGACTTATTTCCATtagatactttaaataaaaatgtggcaGAAGTATCAACTAAAGTAGTGGCAGACACTACATCTGATGAAACAGTACAGTTAGTTGATACCACTGAAAATACTACAATAGATGTTTCTGAAAAAATTTCCTTCATATCTGAAACAGATACTAAAAGTAAAGATTTTGATGAGAGTGAAATAAGGCAGAATGAGCAAGATGAATTAGCTCAAGCTGTTAAAGCTATTGAACAAGAGAATGAAATCTATGAGTCTGCAACTGCGGTTActgttgttaatgttaatgctGCTGATGAATTAACTGAAATATCTGTGATAGATGAAGATGATCAGCCATCAATATCATTGGTgttagatgatgatgatgatgaaagtaTTGAAGTCCTTCATCAAAATGTCAGTCCCATGTCAGTAATGATTGATGAGTCTGAAGTTTCTGTCATCCAAGATAGTGAGGATGATGATTTGCCAATATTGGTTTCAGATACTGTTGATATACCAAtacaacatataatacaaaaatcaccAGAGTCAACTGAAATACGACAAGTGAAAAATAAACAGTCAGAAGTGATAAaaggtgaaataaataaattaattgattcagAATGTAAAGAATTTGCATTGTCTGAAATTAACaaagaagaaaaatgtttaacaataaaagtaaaaaatatagaatctGAACAAAAATCACTTGTGTGTGAGAATATAGAACCTAAAATTACATCAGATCAAAAAATCGACGACAAGAAACATGATGTGTCGTTGGATGAATCTTCGAAAACACTGATAGAGAATGAGATGGCTAAAATAGAAACCTCATTGGACAACAGcagtatacaaacaaataaagataAAGTGAACGATAAAACCTTTGATGAAGTACAAAAAGCAGAAATAGATATTGCTCCAATAGATTCAACTATGTCAAGTAAAGATGAAATAAAACGCTTAGAGAATGTTAATGTTAACCTCTTTTCACCTTCTCAAGATATTGCCCATGATACAAATCATCTAACTTCAttgcttttaaaacaacataaagaTGTTTCAGCAGGTGAACAGAATGCTAATTTACCGGATGAGGTTCCACAAGATATTATACCACAACCGTCAACGTCAACTgataatttgtatgtaaataaagattCATCGAATGACGTTCCAGACTCGGATACGCTTGGCCTCTTAGCGGAGTCCACGAGAGTGATGGATGACGACGAGGATCAGgacgaagaagaagaagatgacgatttttataatgatgatgAAAGCAATTTAATGACAGCAGAGCATTCAGAAGATTCAAACCAGCCATCAGATGATGCTCAGGAAACTCAAGATGTGGTGGAAACTGATGAGAAAGAAATCGCTAAACTTACACAATTAGAAATTACTGATGTCAGTGTGGTTGGTGACCAGGATTATGTGGAGCAAGAATTGGAGTCACCGGAGCATCAAGAGGACAGCTTCCAGTTCACAATTAGTAATGTGACAAATGATGTGCAGAAGGATAATGATGCTTCTGAGATTATGGAGAGTgatATCCAATTAGAAGACAAGTCAGTAGGACCTGTTGAACAGAATATGGACGCTATAAAACACCCTGCGCCTGAAGATGTCGAGAAATCTGTCATAGAACCAGTCCAGACATCAGATATGTCAGAGTTAGTGGGTAAAACAGACAATGAACCTGCTCCTGTGCCAGCTGAGAAAGAGACTAAATCGCCGAACAAAATCATGAGTCTTACCATATCATCAAAGCAAAATGTCTGGAATTTTGTAGACCTCGAGGAGAGCTCGGAAGATGaaattcaaATAGTGCAGAAGCCCATTGAGACGGTCGCCACAACTAATCAAGCAGAGGCGCGTCCAGACCCAGCACAACTGACAACCCAGAAGCAACCAGACGAAGAAACACAACAGACACGGCCAgagAGGACGGCCGCGCCGATGGCGCAGGCCGCGGCGGGGTCAGCCGGCCAGTCCAATGTGGCGACCCTGGATGAGGCTGTGTTACGAGTGGACGACTCAGTTCCAGTAAGTGGCTTGGAAGTGTTTAATCTTGATTCGGATGAAGAAGACACCGTTGAACGTACGGCGCCGGTTGAAgAGCCATTGAGCCAAACAGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCTGGAACCGGAGCCTGAGCCTGCCAAGCGCGACTTTAAGTGCGTAAACAGCAATTGCAAGTATGCCGCCGGTGTTCGGTATTTGGTGGCAGATTCTGCAACGCTGGCCTACTACGAGGGAGAAAAGCGGCGCCGTACGTTCGTATGCGAGGATTGCTGGCGGACAGTACAAGCGCGCAATGAGGAGCTGATGGAAGGCATCCGCAACTTGACGCCCCTGTTGGAGCTGGACATGACCACGTTCAGCCCGGACCTGGTGGAGATATCCGACTCGGACTCCGAGGGGGAGCCCGAAATCGAGGAACACGAGAAGGAGAAGATCGGCGACGTCACCGCCAAATTGTTAGAAGAAAACTTAGCGGATATGATTAATGAGACATGGGTGAAGTACCAAATGGATTCCCGGCTCACCGACACGGAGTCTGTGCTGCAAATGGAGTTGCGGAGACTGGAGGCTGAGAGCAAGGAGATTCACTCGTTCCTGAACGAGTGCCAGGCGACTACGGACAGGATCCGCAACGAGCTGTACGCCACCTTCCCGCAGGAGATCCAGCAGGTGCCGCCGCTGATGGTGTACGACACGCCGGACAAACAGGCGACTACGGACAGGATCCGCAACGAGCTGTACGCCACCTTCCCGCAGGAGATCCAGCAGGTGCCGCCGCTGATGGTGTACGACACGCCGGAAAAACAGAACAAGGAGATTCAGTTGTTCTTGAACGAGTGCCAGGCGACTACGGACAGGATCCGCAACGAGCTGTACGCCACCTTCCCGCAGGAGATCCAGCAGGTGCCGCCGCTGATGGTGTACGACACGCCGGACAAACAGGATCCGCAACGAGCTGTACTCCACCTTCCCGCAGGAGATCCAGCATGTGCCGCCGCTGATGGTGTACGACACGCCGGACAAACAGGTGAGCTCCCTCTCCAGAACAAGGAGATTCAGTTGTTCTTGAACGAGTGCCAGGCGACTCCAGAGAAGATCCGCAATGAGCTGTATGCCAGCGAACCTGCAGGAGATCCTGCAGGTCCCGCGATGTCACCGAAGGACGGAGAGAGCCCGCCTCCGGTTCCGACGCGGATGTCCAAGCGGAGGCTGGAGGCTGCAGCGAACGCGGAGAACCTGGCGCCGGCGAAGCGCCCCGCCATCCCGTTGGGGTACACCCCTTTGGAGGCGCTCGAACAGATGGATAACAAGATGGCCGGGAAGGGCACCGGCGCTGCGGAGAAGGTCGACGATGATAACACAGACGTGTCAGTGGTGAACATAATATCGTCGGAGGCGGCGCCCCCGGGACTCCCGCCGCCCGGCGAGCTGGCAAAGCCGCCGCTCAGGATCGGCATGACGGTGTACGCGATGAAGAACTCCTTCGGCTCCTGGGTCAAGGGCAAGATTCTAGAGATCGTACCAAAGGGAACGTCGCCGACGGCGTTCACGACGTGCAAGGTGAAGTTTGAACATAAGCAGTCCAAGACGCCGGTGAAGACCGTCCTCGCCAGGTCCATGGCGTACTCTGAGCCCGCCGCCGTCAGACTGACCATCGGTACTCGCGTCATTGCTAATTTCAAAGACACGAAAGACAACAAGGAGCCGCCCCAGACGGACTCCAAGCGGGAGTCGTACTTCTCCGGCATAGTCGCGGAAGTGCCCAACCCAGTCAACAACTACAGatatcTGATATTTTTCGACGATGGCTACGCGCAGTACGTGAGCCATGCGGACACTCGGTTGGTGTGCGAGTGCGCATCGCTGGTGTGGGAGGAGGTACATCCCTTCAGTCGGGAGTTCGTTAGGGAGTACCTCCTGGCGTACCCTGAGAGACCTATGGTCAGGCTGCATCCTTTCCAAAGTTTGAAGACGGAATGGAATGGCAAGTGGTGGACGTCGCGCGTGGTGGCGGTGGACGCGTCGCTGGCGCAGGTGCACTTCACCGCCAACAACCGCTACGAGTGGATCTACCGCGGGTCGACGCGCCTCGCGCCGCTCTACCTGGAGCTGCAGGCGGCCGAGCGGCACCGCTCGCGGCCCATGCCGAGGGCGCAGGCGCACGCGAGGGCCAACATGCCCGTGGTGGAGTACACGCGCTACGACGAACAGTCCAACAAGACGTTCGATGTAGACAGCACGCCGCAGCAACAAAAACAGGAAGCGGAGGCGAACCGTCAGCGGGCGGTGGCCAAAAAGTCCACGGGCGGCTCGGTGGGCCAGCCCGCGCCGGCCGCCCGCCTGTCGCCCGGACACAACCTGGACAACGTCACCAGCAGGGTGGTGTATTACACGCCGAAGAATGCGGTGAAACCGCACAAGATGGTTCCGCACACGTGCGGGCCCAAGTGCAAGCGCACCGACGTGCTCGCTCTCAAGGACCTGCGCACCTACAACCCGCTGGCCAAGCCGTTGCTCAGCGGCTGGGAGAGACAAATCGTTCGCTACAAGGGTCAGAAGGCGGTGTCGTACCGCGCACCGTGCGGGCGGCGCGTGCGTAACGCGCACGAGCTGCACCGCTACCTGAGGGCGACGCGCGCCGACCTGCCCGTCGACCTGTTCGATTTCTCGCCCGCCACGCACTGTCTCGCCGAGTTCGTGCTCAACAAGTGCCTCATCATGAAGAAGGATCTGTCCCAGGGCAAGGAGAACGTGCCGGTCCCGTGCGTGAACTACTACGACGAGACGCTGCCGGAGTTCTGTCTGTACAACACGGAGCGCACGCCCACCGCCGGGGTCCCACTCAACCTCGACCCTGAGTTCCTGTGCGGCTGCGACTGCGAGGACGATTGCGAGGACAAATCAAAGTGTGCGTGTTGGAAGTTGACGCTGGAGGGTGCTCGCACCATCGGCCTGGAGGGCGACAACGTGGGCTACGTCTACAAGCGGCTGCCCGAGCCGCTGCCCTCGGGGATATACGAGTGCAACTCCAGGTGCAAATGCAAGCACACTTGCTTGAACCGAGTCGCGCAGCACCCTTTGCAGCTGAAGTTACAGATATTCAAAACCCTAAACCGCGGGTGGGGCATCCGCGCGTTGAACGATGTGCCCAAGGGCTCCTTCTTGTGCGTGTACGCGGGCAACCTTTTAACGGATGCGACCGCTAACATGGACGGTCTGAACGAGGGTGACGAGTACCTCGCCGAGCTGGACTACATCGAGGTGGTGGAGCAGATGAAGGAGGGCTACGAAGACGACATACCCAAGGACGTCAGGAAGGAGCTACAGGACAAAGAGGAAGAAGACGCGGAGCAGGAGGAGTCCTCGGAGGATGAGAGCCAGCGGACGTCCAAGGACGAGCTGGAGGACGACGACTTCGAGCCCGCGCCACACGTGGGCGTCCGCGTCACGCAGTTCAGtaaacGTCTTCGCCAAAGAAACCGGAATAAAGAGGAGAATGCTACCGATGACAAAAAGGAGAGTGAGAAGGAAAAAGTTGAGCCGAAGAAGGAATGCGAGAGGGGGTCGAACGACGAAGATTGCATCACCATAAGCGATGACGACGAAGTGAGGGAGCCGTCCAGCTTCGCCGCCGCCGCGGGGATGGGCGCGAACGCGTTCGTCTCCAAATATAGGTCGGTGCGCAGTTTGTTCGGCGAGGACGAGTCGTGCTACATCATGGACGCTAAGGTTCAGGGCAACATTGGCAGATATTTGAATCACTCGTGCTCGCCGAACGTGTTCGTGCAGAACGTGTTCGTGGACACGCACGACCCGCGCTTCCCGTGGGTGGCGTTCTTCGCGCTGAGCCACGTGCGCGCCGGCACCGAGCTCACCTGGAACTACAACTACGACGTGGGCTCCGTGCCCAACAAGACGCTCTACTGCTACTGCGGCTCCGCCAACTGCAGGGGCCGGCTGCTCTGA
Protein Sequence
MSSKDVEGIIICYNKDTNQSQDKNCEELEKGDLLEKLGSVGPSCTKHVDENNAENTGRVVISTNGNKGNLTDQINSEISIENKEAASLCSVEEEFTSDMQEEEIKLRWDDDEYSVEFGEKVVTTDTSKDTCLNSGKEAINKNELYLLKRSSAIDSGKEFIQNAVVTELISTKPQSESFAEAPVLKSEHGINQPDVMLEIPGMGMLPDMDKELESMDVEMFFDTDKDLSSEDTDKSLSELVSKANDEITETLSSLEESEMDGKLEMSPDKSDDTPAAPTINKTTLTNAFKIEMKLLSDTTISIAEETDPSVDKLSLMEADKMELKCLVKSMSNQEQDDTFDNIPTSLTKPSTVIEEKNVFELQATTSEQREKNMNLKVSTLISSIEEEMQLLDSNDDMDISERTSEIKKLKKPAKIESIIDLFPLDTLNKNVAEVSTKVVADTTSDETVQLVDTTENTTIDVSEKISFISETDTKSKDFDESEIRQNEQDELAQAVKAIEQENEIYESATAVTVVNVNAADELTEISVIDEDDQPSISLVLDDDDDESIEVLHQNVSPMSVMIDESEVSVIQDSEDDDLPILVSDTVDIPIQHIIQKSPESTEIRQVKNKQSEVIKGEINKLIDSECKEFALSEINKEEKCLTIKVKNIESEQKSLVCENIEPKITSDQKIDDKKHDVSLDESSKTLIENEMAKIETSLDNSSIQTNKDKVNDKTFDEVQKAEIDIAPIDSTMSSKDEIKRLENVNVNLFSPSQDIAHDTNHLTSLLLKQHKDVSAGEQNANLPDEVPQDIIPQPSTSTDNLYVNKDSSNDVPDSDTLGLLAESTRVMDDDEDQDEEEEDDDFYNDDESNLMTAEHSEDSNQPSDDAQETQDVVETDEKEIAKLTQLEITDVSVVGDQDYVEQELESPEHQEDSFQFTISNVTNDVQKDNDASEIMESDIQLEDKSVGPVEQNMDAIKHPAPEDVEKSVIEPVQTSDMSELVGKTDNEPAPVPAEKETKSPNKIMSLTISSKQNVWNFVDLEESSEDEIQIVQKPIETVATTNQAEARPDPAQLTTQKQPDEETQQTRPERTAAPMAQAAAGSAGQSNVATLDEAVLRVDDSVPVSGLEVFNLDSDEEDTVERTAPVEEPLSQTEPEPEPEPEPEPEPELEPEPEPAKRDFKCVNSNCKYAAGVRYLVADSATLAYYEGEKRRRTFVCEDCWRTVQARNEELMEGIRNLTPLLELDMTTFSPDLVEISDSDSEGEPEIEEHEKEKIGDVTAKLLEENLADMINETWVKYQMDSRLTDTESVLQMELRRLEAESKEIHSFLNECQATTDRIRNELYATFPQEIQQVPPLMVYDTPDKQATTDRIRNELYATFPQEIQQVPPLMVYDTPEKQNKEIQLFLNECQATTDRIRNELYATFPQEIQQVPPLMVYDTPDKQDPQRAVLHLPAGDPACAAADGVRHAGQTGELPLQNKEIQLFLNECQATPEKIRNELYASEPAGDPAGPAMSPKDGESPPPVPTRMSKRRLEAAANAENLAPAKRPAIPLGYTPLEALEQMDNKMAGKGTGAAEKVDDDNTDVSVVNIISSEAAPPGLPPPGELAKPPLRIGMTVYAMKNSFGSWVKGKILEIVPKGTSPTAFTTCKVKFEHKQSKTPVKTVLARSMAYSEPAAVRLTIGTRVIANFKDTKDNKEPPQTDSKRESYFSGIVAEVPNPVNNYRYLIFFDDGYAQYVSHADTRLVCECASLVWEEVHPFSREFVREYLLAYPERPMVRLHPFQSLKTEWNGKWWTSRVVAVDASLAQVHFTANNRYEWIYRGSTRLAPLYLELQAAERHRSRPMPRAQAHARANMPVVEYTRYDEQSNKTFDVDSTPQQQKQEAEANRQRAVAKKSTGGSVGQPAPAARLSPGHNLDNVTSRVVYYTPKNAVKPHKMVPHTCGPKCKRTDVLALKDLRTYNPLAKPLLSGWERQIVRYKGQKAVSYRAPCGRRVRNAHELHRYLRATRADLPVDLFDFSPATHCLAEFVLNKCLIMKKDLSQGKENVPVPCVNYYDETLPEFCLYNTERTPTAGVPLNLDPEFLCGCDCEDDCEDKSKCACWKLTLEGARTIGLEGDNVGYVYKRLPEPLPSGIYECNSRCKCKHTCLNRVAQHPLQLKLQIFKTLNRGWGIRALNDVPKGSFLCVYAGNLLTDATANMDGLNEGDEYLAELDYIEVVEQMKEGYEDDIPKDVRKELQDKEEEDAEQEESSEDESQRTSKDELEDDDFEPAPHVGVRVTQFSKRLRQRNRNKEENATDDKKESEKEKVEPKKECERGSNDEDCITISDDDEVREPSSFAAAAGMGANAFVSKYRSVRSLFGEDESCYIMDAKVQGNIGRYLNHSCSPNVFVQNVFVDTHDPRFPWVAFFALSHVRAGTELTWNYNYDVGSVPNKTLYCYCGSANCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-