Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 1.1e-05 0.38 10.9 0.9 44 94 19 69 7 81 0.73

2 4 1 3.4e+04 -12.5 30.8 434 492 64 122 60 135 0.73

3 4 0.12 4.1e+03 -2.5 4.4 463 474 170 180 143 189 0.51

4 4 8.3e-10 2.9e-05 24.5 0.3 321 381 213 274 203 295 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	1.1e-05	0.38	10.9	0.9	44	94	19	69	7	81	0.73
2	4	1	3.4e+04	-12.5	30.8	434	492	64	122	60	135	0.73
3	4	0.12	4.1e+03	-2.5	4.4	463	474	170	180	143	189	0.51
4	4	8.3e-10	2.9e-05	24.5	0.3	321	381	213	274	203	295	0.82

Coding Sequence: ATGAAGAATACTGGAGGGTTCCATTCTGCATATACTGTGAACCCGGACGCCCATGACCGCACAACCCAGCAGATCCAGTCGAAGCTAGGCAATTATTCGCTGGTGAAGCACCTGCTGGACGAGCCGAAGCGTCTGATCGGCATCGAGGGCGTGCCAGCGAGTCCGGCGCCGGTCACATCCGGCCACTCGCGTCAACCCTCGAATCGCTGCTCGCCCTCCTCGTCCCAGGAATTCAAGAAACCAGGAGGCAGCGGACCGAGATCCTCGGCCTTGGCCTCATCGAGCTCCTCGGCCTTGACCTCATCGAGCTCCTCGTCATCCGTGGCCCCATCCTCCACATCCACATCCTCGAGCTCATCGTCCCAGCGCGGCGGCTTCGTTAAGCCGGCCGATGGCAAGCCACCCTACGGTGGTAGGGGCGGCTATCCTGGACAGCCGATCAAACATGGCAATAACAGCAACGAGCACCGCAGCCATGGACTTATACCGGCTAAGGGACCGCCAGGTTCCTCCTCATCCTCATCCTCGTCCTCGTCGACGACCCCTTCGGCTGTTGGCTCGGGGATGGGTGGAGCTGGTGGAGGTCTTGGATCCGCTAGCCTGATGGGAGGAAACAATGCCTCCTTACAGAATAGACTGCATAGCGCTAGTGTTAGGCTACCCAAACTTCCTATAGATACTGGTTCGAGTTCCAGACATCTCAGCGCCAATAGTACCGCCGAGGTGGAGACCATCTTAAAGGAAATGACCATGCCGCCAACGCCTTTAACTGCGATCGCCCAAACGCCAAGAAAAGAGATTGAATCGAAGTTTACCTTCAATCCAGTGCTAGCAAAGcTGACAGAAGTGACAGGACAGGAATCAGGGAAGCCTCGCATTGAACTACCAATGGCGTTGATGATAAAATGTACAGAAGAGACAAGTGTTGCATTAGTCGCTAATCAATCGAACTTATGTCTTAGCCCGAATAACCCACTAACATTCTCAATATTCACCCCAATAGACAACAGACATTCACTCGAATATCTCAAGTGA
Protein Sequence: MKNTGGFHSAYTVNPDAHDRTTQQIQSKLGNYSLVKHLLDEPKRLIGIEGVPASPAPVTSGHSRQPSNRCSPSSSQEFKKPGGSGPRSSALASSSSSALTSSSSSSSVAPSSTSTSSSSSSQRGGFVKPADGKPPYGGRGGYPGQPIKHGNNSNEHRSHGLIPAKGPPGSSSSSSSSSSTTPSAVGSGMGGAGGGLGSASLMGGNNASLQNRLHSASVRLPKLPIDTGSSSRHLSANSTAEVETILKEMTMPPTPLTAIAQTPRKEIESKFTFNPVLAKLTEVTGQESGKPRIELPMALMIKCTEETSVALVANQSNLCLSPNNPLTFSIFTPIDNRHSLEYLK

Sequence clustering based on sequence similarity using MMseqs2