Mdol028155.2
Basic Information
- Insect
- Megamerina dolium
- Gene Symbol
- Foxd3
- Assembly
- GCA_963854835.1
- Location
- OY978530.1:30368944-30371538[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 3.5e-35 5.2e-32 110.7 0.0 2 87 365 447 364 448 0.96 2 3 7.8 1.2e+04 -2.6 0.3 19 40 526 547 516 552 0.53 3 3 4.4 6.5e+03 -1.8 0.2 9 42 728 762 725 793 0.71
Sequence Information
- Coding Sequence
- ATGCCAAGCTTGACAGTGCTAAAAATGGAATGCACTATTAGCAATAATgatcataaatacaatattaataataataatgataataataataatgataatagtaatactaataataatgataataataatactaacaaATATATTCGTAAACAACTGTTGTCATCGATTACAAAACGTGTCATTagtaatacaaatgaaaaacagCGGCTAGAGCTACACAAATAtagtaatactaataataataatgatactaattttaataataatagtgaaaataattataatagtgGTAATAacatttgtaatattaaaaataaggtTAACAAGAatggtaataacaataataataataataatactaataataataatgataatgatagcAAAAgcaatggtaataataatagcaataacaataaaaatatcgaGAATAACAATTCCACAAATAACCATGACGATAATAATCACGGTGGCAAAGGTACTATGACATCCAGAGCTAACGCGCTTTCAATCTTAACAAAAGGCAGGTTGGATGAATCCACAATTGAAGCAACATTGCTACTTGGAGAAAATTTTGATAAGAGTATCGACAATTATAATATTGATCCTAGTGAAATAGTTTCGGAAGCGGACTCTTTCCATGATGGTATTAGTTCTTATCGTGGTGTGGTTGAGAGCATTACTAGTGGCGTTTCTAACTTTATACCAACGACTAGAACGACAACTGCAACAATGCCACAAATAACAGCACCATTTGACCAATACCGCTTGCAGTTATATAACTATGCCTTGCATTTTGAACGACTACGTTGTCCATCTCATGCTTCGGTAGCTGCAGTAATGGCTGCTGCTGCAACTGCGACTTACACTAATAACTCTACAAATGTCTGTAACAACAAAAGCAGTTATAGTAGGAGCTGCAGTAATAAGAGCAATGCTGTTGGTTTAATTGATAGTGGGTTAGCTACTAATGGTATTTACGCTGCAGCGTTGGCAGCCACTGCAACCCCCAGTACTGGTCAATATTTACCCGCAAATAATCGattatcattgtcattattTCCACATCGTATTTTCCTGCCGGAACAACCAAAACCTCAGCACAGTTACATTGGGTTGATTGCAATGGCTATACTCAGCTCGGTGGAATCGAAATTGGTTTTGTCTGACATATATCAGTACATATTGGACAATTACCCATATTTTCGTACACGCGGACCTGGTTGGCGGAATTCTATACGCCACAATTTATCTTTAAATGATTGCTTTATAAAGTCTGGACGCAGTGCTAATGGCAAGGGTCACTACTGGGCTATTCATCCAGCTAATTTAGAGGATTTTCGCAAAGGTGATTTCCGCCGCCGTAAAGCTCAACGCAAGGTAAGAAAACATTTGGGTCTGTCAGTAGACGATGCTGGACCTGATTCACCAAGTCCACCGCCACTAGATTTAAGTTCAACCCCACCATCGCTAGTGCCCAAAACTCAATCAGCAGAGGGATTACGATATCCTGTCCCAGTTACAACATTACCTATGCATATAGCACGACAACAACTTACCGCATTTAGCTAttttcaacaacatcaacaacaacaacaacaaatgcaccATTTTCATATGCATCATTACCATCAATATAATCATGACTATCAACCAAATACACATTCGTATCCACAACAGCTACTGCAACAGCCCTTACACACAATTACTGCCGCTAGTACTCCGGCAGCAGCATATGAGCAACAGCAACACTACTTTTCTTACCAAGAGGAAGATTCTGATGCTCTGACTTATATACCACAAAATCCTGTTACATTGGATACTATtaatcaacaacagcaattacAGGAACAACAAAATCAGGAACAAAATCGTCTGCAGTTAGTAGTAGAACATCCACCGCAGCAGTATGCACcttacaacaataacagtaacaaTGTCAACGAAAGCAATAATAGCAGAAATCATCCAACAATAACGCTTATCAATAAAACAATGAATAGAACAGAAACATCAGCAGCGGCTAGTGTTTTAGCCAATTACTATTCGAAGACAACGCGCAAACGGCAATTCGATGTTGCGTCGTTATTGGCGCCTGATGTAAAAGTTGATATTGCAGATGGAAACAAAGCCACCATCGAAAACCGCAATGAGCTGTCGAGCGTAATGACAACACAGCATACGCTCATCGCTAAGGTAAGCGTTCAGcataaacatcatcatcatcatcatcatcacattaAAAATCATATCCATGGAAAGTTTTTCCCATCTTATCAACATCAGTATCATCACATACAACAGTACCAACATCTACCGAAGCAACAACATCAGAAAACTAATAACGTTGCCCTCAATATGGATCAAGAGGAGCAAGAAGATATCGATGTGGTTGCCAGCGATGCGGAAGATGTAAAGAACGATTACACTGAAGGGGATTATGATGAAGATTATGAAGTTTATAATGCTGACGTTAATTATCATAACGATGACGATGAATATGATTATAATGGTGATGGTGTCACAGGCAATGATAATGAAGATAAAGTCATGGAAAATAATGATTTGTTGGACAACAGCAACGATTCATACTAG
- Protein Sequence
- MPSLTVLKMECTISNNDHKYNINNNNDNNNNDNSNTNNNDNNNTNKYIRKQLLSSITKRVISNTNEKQRLELHKYSNTNNNNDTNFNNNSENNYNSGNNICNIKNKVNKNGNNNNNNNNTNNNNDNDSKSNGNNNSNNNKNIENNNSTNNHDDNNHGGKGTMTSRANALSILTKGRLDESTIEATLLLGENFDKSIDNYNIDPSEIVSEADSFHDGISSYRGVVESITSGVSNFIPTTRTTTATMPQITAPFDQYRLQLYNYALHFERLRCPSHASVAAVMAAAATATYTNNSTNVCNNKSSYSRSCSNKSNAVGLIDSGLATNGIYAAALAATATPSTGQYLPANNRLSLSLFPHRIFLPEQPKPQHSYIGLIAMAILSSVESKLVLSDIYQYILDNYPYFRTRGPGWRNSIRHNLSLNDCFIKSGRSANGKGHYWAIHPANLEDFRKGDFRRRKAQRKVRKHLGLSVDDAGPDSPSPPPLDLSSTPPSLVPKTQSAEGLRYPVPVTTLPMHIARQQLTAFSYFQQHQQQQQQMHHFHMHHYHQYNHDYQPNTHSYPQQLLQQPLHTITAASTPAAAYEQQQHYFSYQEEDSDALTYIPQNPVTLDTINQQQQLQEQQNQEQNRLQLVVEHPPQQYAPYNNNSNNVNESNNSRNHPTITLINKTMNRTETSAAASVLANYYSKTTRKRQFDVASLLAPDVKVDIADGNKATIENRNELSSVMTTQHTLIAKVSVQHKHHHHHHHHIKNHIHGKFFPSYQHQYHHIQQYQHLPKQQHQKTNNVALNMDQEEQEDIDVVASDAEDVKNDYTEGDYDEDYEVYNADVNYHNDDDEYDYNGDGVTGNDNEDKVMENNDLLDNSNDSY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -