Mdol009775.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Megamerina dolium
Gene Symbol
fkh
Assembly
GCA_963854835.1
Location
OY978526.1:33528929-33530437[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.3e-39 1.9e-36 124.9 0.0 2 88 199 284 198 284 0.98

Sequence Information

Coding Sequence
ATGCAGAAGCTTTACTCGGAGGCGCCAACGAGCGGTCCAGTTAGCATGACAAGTTCaggtggtggcggtggcggtCCCTCAACCGGAGGTAGCGAAAACAATActggtggcggcggtggtggaGGCAGTGGAGGTGGTGGCAATACGACcattcacaataataacaatgccACATCGAACGGCGGCTCAATGAGTTTAGCACGTTCCGTTTACACAATGAATTCGATGGGCATGCCCGTCGGCGGAATGTCTTCGGTATCACCACAAACAGCCGCCACCTTTGGACCGAGCGTACTGGAATCGGCGGCCGCCGTGGCCAGTATGGGAGGCAGTATGGGAGCAGCAGCAGCTATGAATTCAATGGCAGGCAATTGTATGACACCCAGCTCGATGAGCTATGCGTCAATGGGTTCTCCGCTTGGCAATATGGGCAACTGTATGGGAGCTGGAATGTCTACAATGGCAGCCATGGGTGGATATTCATCGATGGCGGCGGCGGCAAGTGCTCGCGATCTGGATGCGGGCTCACCAAATTCACTGAACAGATCTCGAGTTGAGAAACCCACAACATACAGGCGCAGTTACACGCACGCAAAACCGCCATATTCGTATATTTCCCTAATTACAATGGCAATTCAAAACAATCCGGGGCGCATGCTTACGCTATCCGAGATATATCAATTCATTATGGATCTGTTTCCGTTCTATCGCCAAAATCAGCAACGTTGGCAGAATTCAATACGACACTCGCTGTCATTTAACGATTGCTTTGTGAAAATACCACGAACGCCAGACAAACCTGGCAAGGGGTCATTTTGGACCCTGCATCCCGATTCGGGCAATATGTTCGAAAACGGATGCTATTTGCGGCGCCAAAAACGTTTCAAGGATGAGAAGAAGGAAGCGATTCGACAGCTGCATAAGAGTCCGTCACACAGCAGTCTCGATGCCACTAGTCCCGGTAAGAAGGATCACGAAGATGCCCATCATTTGCACCACCATCACAGTCGAttggatcatcatcatcagcaccatCACGGCAAGGATGGCAGCTCTGCTGTGAGTGGGGGCGGCGTAGGCGGTGTTCTCGGTTCGACACACAGCAAGGATGCAGAGGCCTTGGCGATGTTGCACGCTAACGCTGAAATGTGCTTGGGTCAGCAGGCCCAACATGCGCCCGCGCAccatcatcaacaccatcatcaatTGCAACAAGAGGAACTGTCGGCAATGGTGAACCGGTGCCATCCATCTCTTATCTCGGACTATCATTCCTCCATGCACCATCTGAAGCAGGAACCTTCGGGCTACACACCGTCTAGCCACCCATTCTCCATCAATCGTTTGTTGCCGACCGAATCGAAAGCCGACATCAAGATGTACGATATGAGCCAATACGCTGGCTATAATGCACTCAGCCCTTTGACGAATTCACATGCTGCCTTAGGACAAGACTCCTACTATCAGAGTTTAGGCTACCACGCACCTGCTGGTACGACCAGCTTGTGA
Protein Sequence
MQKLYSEAPTSGPVSMTSSGGGGGGPSTGGSENNTGGGGGGGSGGGGNTTIHNNNNATSNGGSMSLARSVYTMNSMGMPVGGMSSVSPQTAATFGPSVLESAAAVASMGGSMGAAAAMNSMAGNCMTPSSMSYASMGSPLGNMGNCMGAGMSTMAAMGGYSSMAAAASARDLDAGSPNSLNRSRVEKPTTYRRSYTHAKPPYSYISLITMAIQNNPGRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLDATSPGKKDHEDAHHLHHHHSRLDHHHQHHHGKDGSSAVSGGGVGGVLGSTHSKDAEALAMLHANAEMCLGQQAQHAPAHHHQHHHQLQQEELSAMVNRCHPSLISDYHSSMHHLKQEPSGYTPSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00624545; iTF_01045281; iTF_01505194; iTF_00081001; iTF_00192619; iTF_00193357; iTF_00082738; iTF_00189750; iTF_01114017; iTF_01114819; iTF_00384383; iTF_01363746; iTF_01174883; iTF_00061733; iTF_00653386; iTF_00060909; iTF_00062553; iTF_00352357; iTF_01180963; iTF_01426476; iTF_01414766; iTF_01022805; iTF_00351673; iTF_01189190; iTF_00191891; iTF_01314471; iTF_00899330; iTF_00976264; iTF_00817225; iTF_01176745; iTF_00797546; iTF_01055036; iTF_00992363; iTF_01357735; iTF_01563501; iTF_00090973; iTF_01562577; iTF_01051021; iTF_01200717; iTF_00366313; iTF_01378190; iTF_01195087; iTF_01195818; iTF_00251153; iTF_00613318; iTF_00489185; iTF_00489890; iTF_00569506; iTF_00571714; iTF_00477827; iTF_00525699; iTF_00540899; iTF_00482792; iTF_00527115; iTF_00488524; iTF_00484945; iTF_00594353; iTF_00561554; iTF_00532917; iTF_00491321; iTF_01427282; iTF_00971990; iTF_01485979; iTF_00257619; iTF_00746519; iTF_00747279; iTF_00750261; iTF_00748790; iTF_00748029; iTF_00749502; iTF_01259031; iTF_01165345; iTF_01312835; iTF_01235529; iTF_01194186; iTF_01373869; iTF_00997518; iTF_00975408; iTF_01236464; iTF_00331347; iTF_00921908; iTF_00199669; iTF_01237462; iTF_01162071; iTF_00045178; iTF_01313563; iTF_00349980; iTF_01201407; iTF_01260800; iTF_01315296; iTF_01399268; iTF_01074250; iTF_01398235; iTF_01397130; iTF_00892525; iTF_00741655; iTF_01137784; iTF_01173977; iTF_01109152; iTF_01376439; iTF_00435330; iTF_00655139; iTF_00759892; iTF_00900345; iTF_00890776; iTF_01231399; iTF_00889932; iTF_00679285; iTF_00716440; iTF_00891674; iTF_00370780; iTF_00259582; iTF_00258673; iTF_01132728; iTF_01470311; iTF_01374776; iTF_01404634; iTF_00979170; iTF_00665439; iTF_00694401; iTF_00984034; iTF_00893668; iTF_01396295; iTF_00426923; iTF_00426156; iTF_00974445; iTF_00187858; iTF_01318035; iTF_00663862; iTF_00693590; iTF_00334775; iTF_01356668; iTF_00313254; iTF_01002566; iTF_00310026; iTF_00312396; iTF_00314956; iTF_01541964; iTF_00389425; iTF_00671410; iTF_01541236; iTF_00240470; iTF_01299822; iTF_01521685; iTF_01300635; iTF_00672662; iTF_00672013; iTF_00670750; iTF_01395638; iTF_00664663; iTF_00314074; iTF_00315746; iTF_01211707; iTF_00816352;
90% Identity
iTF_00797546;
80% Identity
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