Mdil008812.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Megalocaria dilatata
Gene Symbol
GIS1
Assembly
GCA_034642435.1
Location
CM067855.1:69873335-69886625[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 32 0.00077 0.087 14.5 0.5 2 23 176 198 175 198 0.94
2 32 0.00026 0.029 16.0 0.6 1 23 204 226 204 226 0.98
3 32 0.00052 0.059 15.0 4.7 1 23 232 254 232 254 0.95
4 32 3.7e-05 0.0041 18.6 1.8 1 23 260 282 260 282 0.98
5 32 0.0026 0.3 12.8 0.3 2 23 414 436 413 436 0.94
6 32 0.00026 0.029 16.0 0.6 1 23 442 464 442 464 0.98
7 32 0.00052 0.059 15.0 4.7 1 23 470 492 470 492 0.95
8 32 3.7e-05 0.0041 18.6 1.8 1 23 498 520 498 520 0.98
9 32 0.0026 0.3 12.8 0.3 2 23 652 674 651 674 0.94
10 32 0.00026 0.029 16.0 0.6 1 23 680 702 680 702 0.98
11 32 0.00052 0.059 15.0 4.7 1 23 708 730 708 730 0.95
12 32 0.00021 0.024 16.2 0.6 1 21 736 756 736 757 0.94
13 32 0.0064 0.72 11.6 0.2 2 23 890 912 889 912 0.94
14 32 0.00026 0.029 16.0 0.6 1 23 918 940 918 940 0.98
15 32 5.9e-05 0.0067 18.0 4.4 1 23 946 968 946 968 0.95
16 32 3.7e-05 0.0041 18.6 1.8 1 23 974 996 974 996 0.98
17 32 0.0026 0.3 12.8 0.3 2 23 1128 1150 1127 1150 0.94
18 32 0.00026 0.029 16.0 0.6 1 23 1156 1178 1156 1178 0.98
19 32 0.00052 0.059 15.0 4.7 1 23 1184 1206 1184 1206 0.95
20 32 3.7e-05 0.0041 18.6 1.8 1 23 1212 1234 1212 1234 0.98
21 32 0.0052 0.58 11.9 0.3 3 23 1250 1271 1249 1271 0.95
22 32 0.00012 0.014 17.0 0.9 1 23 1277 1299 1277 1299 0.98
23 32 0.00052 0.059 15.0 4.7 1 23 1305 1327 1305 1327 0.95
24 32 3.7e-05 0.0041 18.6 1.8 1 23 1333 1355 1333 1355 0.98
25 32 0.0064 0.72 11.6 0.2 2 23 1487 1509 1486 1509 0.94
26 32 0.00026 0.029 16.0 0.6 1 23 1515 1537 1515 1537 0.98
27 32 5.9e-05 0.0067 18.0 4.4 1 23 1543 1565 1543 1565 0.95
28 32 3.7e-05 0.0041 18.6 1.8 1 23 1571 1593 1571 1593 0.98
29 32 0.0026 0.3 12.8 0.3 2 23 1725 1747 1724 1747 0.94
30 32 0.00026 0.029 16.0 0.6 1 23 1753 1775 1753 1775 0.98
31 32 0.00052 0.059 15.0 4.7 1 23 1781 1803 1781 1803 0.95
32 32 3.7e-05 0.0041 18.6 1.8 1 23 1809 1831 1809 1831 0.98

Sequence Information

Coding Sequence
atggagaataatagtgatgtccatttttctcaactagaacagaacgttcatgaacggacagattcttttctatgtgaaaaatgcggaatgatcctttactcggaaatttcatttcatttccatctgcaatattaccatcataaacccttattcaataaatggagttctcttatagatgagtgtttgcaaactgaagtttccccaaatgcaacgaaccttgacgtcttaccgacggaaacgttcggtaacattgtcgaaatgccaaaagacttcaacaagaaaaacttcgatgataactgttcgatgaaggggaataatggtatatttgtttacccatcagatgatatgaaccttcttccagattcttacgcaggcttggcgtacaagtataatgtcacaaacgaagtgaaatggattgataataccaaaaatcccacgcaagttcttccaacgattcaaaatatccattcgttaagcagcaatgatcaacttatttcaattaaagaaaatgttatgtgtgatttagtctgcgtgatatgtaataaaaccttcagcaaggccatgtatctcactcaacacaataaaagtattcactctggtgaaaagcccttcaaatgtaaacgttgtggaaagagataccaagacaacgatgcatatgaaatacacatcgccaagcatggagatgataagcctcacaaatgctcaaattgcgaaaaaagtttcaattacaaggccgacttaaagagacacaagtatttacacgcagatataaagccattctcttgtgaagtatgtaataaagctttcataaggaacgatcatatgctgaaacatgtgaaatcacacatacgcagggcacataataagactagtggtgttggagggggaaatgagtgtttgcaaactgaagtttccccaaatgcaacgaaccttgacgtcttaccgacggaaacgttcggtaaaattgtcgaaatgccaaaagacttcaacaagaaaaacttcgatgataactgttcgatgaaggggaataatggtatatttgtttacccatcagatgatatgaaccttcttccagattcttacacaggcttggcgtacaagtataatgtcacaaacgaagtgaaatggattgataataccaaaaatcccacgcaagttcttccaacgattcaaaatatccattcgttaagcagcaatgatcaacttatttcaattaaagaaaatgtcatgtgtgatttagtctgcgtgatatgtaataaaatcttcagcaaggccatgtatctcactcaacacaataaaagtattcactctggtgaaaagcccttcaaatgtaaacgttgtggaaagagataccaagacaacgatgcatatgaaatacacatcgccaagcatggagatgataagcctcacaaatgctcaaattgcgaaaaaagtttcaattacaaggccgacttaaagagacacaagtatttacacgcagctataaagccattctcttgtgaagtatgtaataaagctttcataaggaacgatcatatgctgaaacatgtgaaatcacacatacgcagggcacataataagactagtggtgttggagggggaaatgagtgtttgcaaactgaagtttccccaaatgcaacgaaccttgacgtcttaccgacggaaacgttcggtaacattgtcgaaatgccaaaagacttcaacaagaaaaacttcgatgataactgttcgatgaaggggaataatggtatatttgtttacccatcagatgatatgaaccttcttccagattcttacacaggcttggcgtacaagtataatgtcacaaacgaagtgaaatggattgataataccaaaaatcccacgcaagttcttccaacgattcaaaatatccattcgttaagcagcaatgatcaacttatttcaattaaagaaaatgttatgtgtgatttagtctgcgtgatatgtaataaaatcttcagcaaggccatgtatctcactcaacacaataaaagtattcactctggtgaaaagcccttcaaatgtaaacgttgtggaaagagataccaagacaacgatgcatatgaaatacacatcgccaagcatggagatgataagcctcacaaatgctcaaattgcgaaaaaagtttcaattacaaggccgacttaaagagacacaagtatttacacgcagctacaaagccattctcttgtgaagtatgtaataaagctttcataaggaacgatcatatgctgaaacatgtgaaatcatacatacgcagggcacataataagactagtggtgttggagggggaaatgagtgtttgcaaactgaagtttccccaaatgcaacgaaccttgacgtcttaccgacggaaacgttcggtaacattgtcgaaatgtcaaaagacttcaacaagaaaaacttcgatgataactgttcgatgaaggggaataatggtatatttgtttacccatcagatgatatgaaccttcttccagattcttacacaggcttggcgtacaagtataatgtcacaaacgaagtgaaatggattgataataccaaaaatcccacgcaagttcttccaacgattcaaaatatccattcgttaagcagcaatgatcaacttatttcaattaaagaaaatgttatgtgtgatttagtctgcgtgatatgtaataaaatcttcagcaaggccgtgtttctcactcaacacaataaaagtattcactctggtgaaaagcccttcaaatgtaaacgttgtggaaagagataccaagacaacgatgcatatgaaatacacatcgccaagcatggagatgataagcctcacaaatgctcaaattgcggaaaaagtttcaattacaaggccgacttaaagagacacaagtatttacacgcagctataaagccattctcttgtgaagtatgtaataaagctttcataaggaacgatcatatgctgaaacatgtgaaatcacacatacgcagggcacataataagactagtggtgttggagggggaaatgagtgtttgcaaactgaagtttccccaaatgcaacgaaccttgacgtcttaccgacggaaacgttcggtaacattgtcgaaatgccaaaagacttcaacaagaaaaacttcgatgataactgttcgatgaaggggaataatggtatatttgtttacccatcagatgatatgaaccttcttccagattcttacacaggcttggcgtacaagtataatgtcacaaacgaagtgaaatggattgataataccataaatcccacgcaagttcttccaacgattcaaaatatccattcgttaagcagcaatgatcaacttatttcaattaaagaaaatgttatgtgtgatttagtctgcgtgatatgtaataaaatcttcagcaaggccatgtatctcactcaacacaataaaagtattcactctggtgaaaagcccttcaaatgtaaacgttgtggaaagagataccaagacaacgatgcatatgaaatacacatcgccaagcatggagatgataagcctcacaaatgctcaaattgcgaaaaaagtttcaattacaaggccgacttaaagagacacaagtatttacacgcagctataaagccattctcttgtgaagtatgtaataaagctttcataaggaacgatcatatgctgaaacatgtgaaatcacacatacgcagggcacataataagactagtggtgttggagggggaatctgcgtgatatgtaataaaatcttcagcaaggccatgtatctcactcaacacaataaaagtattcactctggtgaaaagcccttcaaatgtaaacgttgtggaaagagataccaagacaacgatgcatatgaaatacacatggccaagcatggagatgataagcctcacaaatgctcaaattgcgaaaaaagtttcaattacaaggccgacttaaagagacacaagtatttacacgcagctataaagccattctcttgtgaagtatgtaataaagctttcataaggaacgatcatatgctgaaacatgtgaaatcacacatacgcagggcacataataagactagtggtgttggagggggaaatgagtgtttgcaaactgaagtttccccaaatgcaacgaaccttgacgtcttaccgacggaaacgttcggtaacattgtcgaaatgtcaaaagacttcaacaagaaaaacttcgatgataactgttcgatgaaggggaataatggtatatttgtttacccatcagatgatatgaaccttcttccagattcttacacaggcttggcgtacaagtataatgtcacaaacgaagtgaaatggattgataataccaaaaatcccacgcaagttcttccaacgattcaaaatatccattcgttaagcagcaatgatcaacttatttcaattaaagaaaatgttatgtgtgatttagtctgcgtgatatgtaataaaatcttcagcaaggccgtgtttctcactcaacacaataaaagtattcactctggtgaaaagcccttcaaatgtaaacgttgtggaaagagataccaagacaacgatgcatatgaaatacacatcgccaagcatggagatgataagcctcacaaatgctcaaattgcggaaaaagtttcaattacaaggccgacttaaagagacacaagtatttacacgcagctataaagccattctcttgtgaagtatgtaataaagctttcataaggaacgatcatatgctgaaacatgtgaaatcacacatacgcagggcacataataagactagtggtgttggagggggaaatgagtgtttgcaaactgaagtttccccaaatgcaacgaaccttgacgtcttaccgacggaaacgttcggtaacattgtcgaaatgccaaaagacttcaacaagaaaaacttcgatgataactgttcgatgaaggggaataatggtatatttgtttacccatcagatgatatgaaccttcttccagattcttacacaggcttggcgtacaagtataatgtcacaaacgaagtgaaatggattgataataccataaatcccacgcaagttcttccaacgattcaaaatatccattcgttaagcagcaatgatcaacttatttcaattaaagaaaatgttatgtgtgatttagtctgcgtgatatgtaataaaatcttcagcaaggccatgtatctcactcaacacaataaaagtattcactctggtgaaaagcccttcaaatgtaaacgttgtggaaagagataccaagacaacgatgcatatgaaatacacatcgccaagcatggagatgataagcctcacaaatgctcaaattgcgaaaaaagtttcaattacaaggccgacttaaagagacacaagtatttacacgcagctataaagccattctcttgtgaagtatgtaataaagctttcataaggaacgatcatatgctgaaacatgtgaaatcacacatacgcagggcacataataagactagtggtgttggagggggaagtaaacgacggtga
Protein Sequence
MENNSDVHFSQLEQNVHERTDSFLCEKCGMILYSEISFHFHLQYYHHKPLFNKWSSLIDECLQTEVSPNATNLDVLPTETFGNIVEMPKDFNKKNFDDNCSMKGNNGIFVYPSDDMNLLPDSYAGLAYKYNVTNEVKWIDNTKNPTQVLPTIQNIHSLSSNDQLISIKENVMCDLVCVICNKTFSKAMYLTQHNKSIHSGEKPFKCKRCGKRYQDNDAYEIHIAKHGDDKPHKCSNCEKSFNYKADLKRHKYLHADIKPFSCEVCNKAFIRNDHMLKHVKSHIRRAHNKTSGVGGGNECLQTEVSPNATNLDVLPTETFGKIVEMPKDFNKKNFDDNCSMKGNNGIFVYPSDDMNLLPDSYTGLAYKYNVTNEVKWIDNTKNPTQVLPTIQNIHSLSSNDQLISIKENVMCDLVCVICNKIFSKAMYLTQHNKSIHSGEKPFKCKRCGKRYQDNDAYEIHIAKHGDDKPHKCSNCEKSFNYKADLKRHKYLHAAIKPFSCEVCNKAFIRNDHMLKHVKSHIRRAHNKTSGVGGGNECLQTEVSPNATNLDVLPTETFGNIVEMPKDFNKKNFDDNCSMKGNNGIFVYPSDDMNLLPDSYTGLAYKYNVTNEVKWIDNTKNPTQVLPTIQNIHSLSSNDQLISIKENVMCDLVCVICNKIFSKAMYLTQHNKSIHSGEKPFKCKRCGKRYQDNDAYEIHIAKHGDDKPHKCSNCEKSFNYKADLKRHKYLHAATKPFSCEVCNKAFIRNDHMLKHVKSYIRRAHNKTSGVGGGNECLQTEVSPNATNLDVLPTETFGNIVEMSKDFNKKNFDDNCSMKGNNGIFVYPSDDMNLLPDSYTGLAYKYNVTNEVKWIDNTKNPTQVLPTIQNIHSLSSNDQLISIKENVMCDLVCVICNKIFSKAVFLTQHNKSIHSGEKPFKCKRCGKRYQDNDAYEIHIAKHGDDKPHKCSNCGKSFNYKADLKRHKYLHAAIKPFSCEVCNKAFIRNDHMLKHVKSHIRRAHNKTSGVGGGNECLQTEVSPNATNLDVLPTETFGNIVEMPKDFNKKNFDDNCSMKGNNGIFVYPSDDMNLLPDSYTGLAYKYNVTNEVKWIDNTINPTQVLPTIQNIHSLSSNDQLISIKENVMCDLVCVICNKIFSKAMYLTQHNKSIHSGEKPFKCKRCGKRYQDNDAYEIHIAKHGDDKPHKCSNCEKSFNYKADLKRHKYLHAAIKPFSCEVCNKAFIRNDHMLKHVKSHIRRAHNKTSGVGGGICVICNKIFSKAMYLTQHNKSIHSGEKPFKCKRCGKRYQDNDAYEIHMAKHGDDKPHKCSNCEKSFNYKADLKRHKYLHAAIKPFSCEVCNKAFIRNDHMLKHVKSHIRRAHNKTSGVGGGNECLQTEVSPNATNLDVLPTETFGNIVEMSKDFNKKNFDDNCSMKGNNGIFVYPSDDMNLLPDSYTGLAYKYNVTNEVKWIDNTKNPTQVLPTIQNIHSLSSNDQLISIKENVMCDLVCVICNKIFSKAVFLTQHNKSIHSGEKPFKCKRCGKRYQDNDAYEIHIAKHGDDKPHKCSNCGKSFNYKADLKRHKYLHAAIKPFSCEVCNKAFIRNDHMLKHVKSHIRRAHNKTSGVGGGNECLQTEVSPNATNLDVLPTETFGNIVEMPKDFNKKNFDDNCSMKGNNGIFVYPSDDMNLLPDSYTGLAYKYNVTNEVKWIDNTINPTQVLPTIQNIHSLSSNDQLISIKENVMCDLVCVICNKIFSKAMYLTQHNKSIHSGEKPFKCKRCGKRYQDNDAYEIHIAKHGDDKPHKCSNCEKSFNYKADLKRHKYLHAAIKPFSCEVCNKAFIRNDHMLKHVKSHIRRAHNKTSGVGGGSKRR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00965360; iTF_00965362;
90% Identity
iTF_00965360; iTF_00965362;
80% Identity
-