Basic Information

Insect: Megalocaria dilatata
Gene Symbol: MBD-R2
Assembly: GCA_034642435.1
Location: CM067855.1:14298226-14313056[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.6e-16 1.4e-12 48.2 0.1 7 58 365 416 359 438 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.6e-16	1.4e-12	48.2	0.1	7	58	365	416	359	438	0.84

Sequence Information

Coding Sequence: ATGAGTGAACCCACGGAGGTTCAAGATGCTGTAGCATCTACTTTAGCAACGCCATTCGCGCAGCCAATAATCACTGCTTCAAAATCGAAAGCCCAAAAACAACGTGAGTACAGACAGCGTATCACAGCATCTAGAACTCCTGCTCAGGCGGCTGCTGCGAGAAAATCGAAAAACGAAAGACAACGCAACAACAGATTACGCCAAGCTGCTAACTTGGCTATTGCCTGTAATTCTCTTGAAAGGACAACTACATCTCCATCTCGTTCAGGGGAAGAGTCGAAcaatgtccaaactagaagtcAACGACAACACGCGCAACAACAATCTACCACCACTGCAGATCAACCTGATGAGCGTGTCAATCTCACAAATGAGCCACTCTTTCCTGCAATTCCTGTTCCCATGAAGGTTCAAGAAGCTGTTGCATCTACCTCTGCGACGCTATTTGCAGAACCAACAACTGCTGCTCCAAAAACAAGGGCACAAATACAACGTGAGTACAGACAGCGGATTGCTGCATCCAAAACTCCTGCACAGGCAGCAGCTGCAAGAGAAGCACGTAATGTAAGAGATCGAAACAACAGATTACGCCAAGCTGCTAACTTGGTTATTGCAAGTGGTTCTCTAGAAGGGACAACTACATCCTCATCTCGTTCAGGGCAAAGGTTAAACACCGTCCATATTGATACTCTACGACAATTTACCGACCAACAACGTCAAACTTTAGCAACAGAACCAGCAGAAAGTACTGTACAACCAAGTACTTCTTCAGATCAAATTGAAGTTCAAGCACAATCTACTTGGAACACTAAATGGTCATCAATCATAAGATTCaaatctacttttttggacaacgATTTTGGCTACGCTTGCTCGGTCTGTGACAGACTTTGGTTTAGAAACGACCTTAAACCCATCACTGCAGCACAGCTGAAGGTAATTTCGGATTGGTTTATCAAAGAAAATCGACAACTGAGCAGCGAAGAATATGAACTGGTTTGCAACACTTGCAGAAAGTGGGTAGATGGGCATCCCGTTGGTACGGAGTCGCAGTTAGAATTTCAGGATGGAACTAAGAAATCTGTAATCGTGCCTGATCCTCGATTGCCTAAAGGATGGTCAAAACATTTATACAAGCGTAGTCAGGGATTGACCGTCGGTAAATGGGATACAATTATAGTGAGCCCAGATGGAAAGAAGTTAAGATCTAAAACGGACATAAAAAATTATCTTGAGAGTACCAAGCTCCTGAtctatgatgaaaaatttttcgacTTTAGAATCtctataaataaaagaaaaaaaactggtcaaacaacagaaacaaaaaaaagtaCGGAAGTTAAACCAGCCACAATCAAACCACTAGAAGATGAGCAACCCATTCCAGAAGTGAACACTGAAGAGGAAGCTAACCTTTTGAAAATTCCTTTAGTTGATGATGGTTATAAATGTCCCATCGAAGGGTGTGACAAATCTTTTCGTAAAGAGAATTTGGCACAAATGCATGTGAAACACTATCATCCTGAATACAGCAAATTTTTAGACACCACCCCTAACGTTGCCGATTTAGCGTATGCTAGAACAGTAGGAGACTCACTCGATAAATCTCCTGTTCCATCAAAGTCTTCTAGAATTAAACAGACTGCTCACAAACCCTACCAAAACCAGCCTAACTCTCCTATCGtggaagaatcagaaaaaaattttcatcaggCTCGCCCTCCGTCAAGCGCGAAAGATGCAGAAATTATAAAGCTTCTAAGTGCTAAACCGTATGATTCAAAGAGCGAAGGAGAACCCTTACCTCCAGGTTTGCCTCCCAGTATGTATCCCGATATAAAATTGAAAGATTTGTTGAATAAATCTGAAGGTGTTCCAAAAAGAGACgatataaatttgaaaactcTCAGTACTACTCGACCGCCGGTTGGTATCAAAACTTTGCTTCCCGTCAGAAAACCAGAAATTAAAAATGAAGAAGAGTCTCCTGTTGAGGAAGCTACTCTGAAGGTCAAATCAAAGTTGGGCGGAAAGCGAAAAAAGGCTTCCAACGAACAAGCGGAACCTGTCAAAACCAAAGAGGTGAAGGATGAATATCTTCCTCAAACTGTGCCGCCACAGATTGAATCGGCTGTTCAGCCTGAGACCAACAATGTCATCATGGAGGGGGGAGAACTCATAAAGATCGTGCGTATGAAACAGGAAGAAATCATTAATTGTACCTGTGGATTTATGGAAGAGGATGGTCTGATGATACAGTGCGAATTGTGTTTATGTTGGCAACACGCCTACTGCAACAATATTCAGAAGGAGAGTGAAGTTCCTGACAAATACGTTTGTTACATATGCCAGCACCCGTTGAGGCAGAGGACTTCCAAACGGTTTTGTTATGATCAAGATTGGTTGAAGCAGGGAGTTCTACCTGTGGGTTCATATCATAGCAAAGACGAAGAATTGTTACAGAAAAggtttgaaaagttgaaaaaatctCACGATATTTCCGGGGGTCTCGTAGAACTTCAGGAGTTTGTGAATACACTGAAGgtgaaactgaaaatttcagaagCAAAAAATCACCCGAAACTCTATTTATGGTCCAAGCCATGGGAAAAATTACCCTTACCAGAGAAAATGGAAGAAGATCAAAAGAATCCAGTCAAAGAAGAGGGCTTGgtggaaaaattagaaaatgagGAGGAAAATCAACTCAATAGAGATTTAAAGAGCATGATTGAAATCAATCAACCTCAAGTACCAATAATTCCGCAGCCTGAAGCTGCCATCGAAACGGCAGATTGTAAATTGAATCTGTTGGATCATATTCTACATTCTCAAAATCTCGTAATGGAGCGTTTAGATGATTTTGAGAAAGAATTGGACAATTTGGAAGAAAGTGTTACACAATTGGAGAAAGATGAGGATTTCCCCCGATCAAGGCAAACTTTGCAGATGCTAATGAGAGATTTGAATAAGTTAGAAGAACTTAGTCAAAACACAAGTATTTAA
Protein Sequence: MSEPTEVQDAVASTLATPFAQPIITASKSKAQKQREYRQRITASRTPAQAAAARKSKNERQRNNRLRQAANLAIACNSLERTTTSPSRSGEESNNVQTRSQRQHAQQQSTTTADQPDERVNLTNEPLFPAIPVPMKVQEAVASTSATLFAEPTTAAPKTRAQIQREYRQRIAASKTPAQAAAAREARNVRDRNNRLRQAANLVIASGSLEGTTTSSSRSGQRLNTVHIDTLRQFTDQQRQTLATEPAESTVQPSTSSDQIEVQAQSTWNTKWSSIIRFKSTFLDNDFGYACSVCDRLWFRNDLKPITAAQLKVISDWFIKENRQLSSEEYELVCNTCRKWVDGHPVGTESQLEFQDGTKKSVIVPDPRLPKGWSKHLYKRSQGLTVGKWDTIIVSPDGKKLRSKTDIKNYLESTKLLIYDEKFFDFRISINKRKKTGQTTETKKSTEVKPATIKPLEDEQPIPEVNTEEEANLLKIPLVDDGYKCPIEGCDKSFRKENLAQMHVKHYHPEYSKFLDTTPNVADLAYARTVGDSLDKSPVPSKSSRIKQTAHKPYQNQPNSPIVEESEKNFHQARPPSSAKDAEIIKLLSAKPYDSKSEGEPLPPGLPPSMYPDIKLKDLLNKSEGVPKRDDINLKTLSTTRPPVGIKTLLPVRKPEIKNEEESPVEEATLKVKSKLGGKRKKASNEQAEPVKTKEVKDEYLPQTVPPQIESAVQPETNNVIMEGGELIKIVRMKQEEIINCTCGFMEEDGLMIQCELCLCWQHAYCNNIQKESEVPDKYVCYICQHPLRQRTSKRFCYDQDWLKQGVLPVGSYHSKDEELLQKRFEKLKKSHDISGGLVELQEFVNTLKVKLKISEAKNHPKLYLWSKPWEKLPLPEKMEEDQKNPVKEEGLVEKLENEEENQLNRDLKSMIEINQPQVPIIPQPEAAIETADCKLNLLDHILHSQNLVMERLDDFEKELDNLEESVTQLEKDEDFPRSRQTLQMLMRDLNKLEELSQNTSI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -