Mfla013086.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Mecyna flavalis
Gene Symbol
egg
Assembly
GCA_949319885.1
Location
OX439423.1:4645325-4682847[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.2 1.1e+03 0.2 0.1 17 38 1641 1676 1638 1678 0.89
2 2 2.4e-14 1.4e-10 41.5 0.0 4 75 1708 1772 1705 1774 0.90

Sequence Information

Coding Sequence
ATGAGTAGCGACCAAGGAGACCAGACTTTAAAAGACAATGAGGATATTCTGACAAACTCACCAGATACAGGAGAAAAAGGAAATTTATCTCAAATAGAGTCCAGTGACCTTGTCGACCATTCCGTAAGCCCTACACCTAAATATGATCAAATAGAACCTTTGAAAGAGGGTCTTGATGTAATTTCTGCTAAATCCAACACGGATTCTGGCTTCAAAGACCCTGGAGCTGGTCCTACTGATAAAACTGACTTCGATACGAGTAGTGATGATGAAGATCTTCATTTAAAATGGGAAGATGATGAAACAGAGGAACAAGCCGAACCTGTACCTAAAGAAGTGGATAAAAATGTCTCTAAAGCTTTGGATGAGGATGAGGGTGTGACCGATGAAGCTCTTGATGAAAATTTATTACTAGAAAGTCCAGAAGAGGCTGACAAAATGGATGTATCAGTAAATCCTGAAGGGAAACCTGAAGATCTTCAAGAACCAGAGACAAATGTAGTTGATATAGACAAACTATTGAagagtgatgatgatgatataacaGATGAAAGTAAAACTACAAAATCTGAACCTGAATTGAATACTAACATCCTTGAAATGACACCAGATAGTTCAGACAAAACTACTGTTAAAGAGACAAATGTTAAATCTAATGAAAATGAGGACAGTATTGATAAAGGAACACTAAATACTGCACCTGTTGAAgaaattaaagaaaacattGCAGGAAAAGAAACAACTGATATGCCAATCACTGATACTAACAATAAAGACGAAAGTGCCATTGAAGAAACAAATGTTAAATCCATTGAAAAAGAGGACAGTATTGATCAAGAAATACGAAATACTGCACCTGTTGAAGAAATTAAAGAAATCATTGCAGGAAATGTGTCAGGAAAAGAAACAACTGATATGCCAATCACAGATACTCACAATAAAGACGAAAGTGTCACAAATGATAGCATAATAGCTACTAGCTCTCCCAATGAATCTTTTAGTAACACTACAATAGATGCCATATCAGATCACAGGCTGAACAAACCTGATGCAATGCTAGAAATACCTACACAAGAAGTTATTGACATTTTAGATGATACTGATATTTCTATAGCTGATGCTGATAACACAGAAATGGAAAATTCTCTCAAATCTCAACAAACTGAAGATGCAAAGGTTGACACAATTGATGTTACTGATAAAACAATTGAAACTGTTCAATTACAATCTAAAGAAGAACAGACAATTGAATTAGACAGTGCTGTATTTGAAGTTGACTTGAAAGAACAAGTAACCGTGCAGACGTCAACAGTATCAGAAGACGATTGGTCAGAAATAGAAAGGAAATTAAAAGGATTTGAAACTTCTCTCGTAGAAGATTCTGGAAGCAAAGTCGAAGTTAAAACTTCAGCAGAAGATTCTGAAAGTAAAATTGACAGCACAAAAGCTGAAAGCAATAAGTCACCTAATGCTGAAATCCTAGAATCTAAAGAACTTGAGAAAAGTCGTGAAGATAACTCTAAAACAGATACAAATCAACAACCAAATGAGTCGAGTGAAGTGAGAGAGTTGGGTGAAGTACCCAAACCTGCTAGTCCTATTCACAAACCTAAATTAAAATTACGAGACATAGGTTCTTTACTAGCTAAGCCTATAACTACATCAGctgaaattataaatattgatgAATCATCGTTAACTGAATTTCCAGAGACTTTGTATAAATCAATAGATTTAATTAGTGAAGATAGTAATGACAAAACAATATCTGATAAATTAGACTCTATATCACTAATAAAGGCACAGTCCTCCGAGGAAATGTTGATTGAATCTATGACAGATGTCAACATACTGCCAGATATTGATAGCCATCCAACAGAAGATTTAAATATGGATGTTGATGAGGAACCATCCAACTCTGAGGTGGATGTTGAAAAAACAGCTAGTCTATTTGACACAGTTATTAAAATAGATGATTCCACAAAATCTATATCAAAAATGGATGTTGACGCTGAAAATATTGAACCGACAATTCAGTCTTCATCTCAACAACTTGAAAATCTAACAATTTCAAAAGATAATGAAGTACCAACAAATGTAACAAGTGATCCTCTAACACTTGAAGGCACAACAACAATAATTGAAGTCCAACCATCTACTTTAATCAAGGTTATATCAAAGTCATCTACTTCAGAAGCAGATGAAGTACAACCATCAACTTCTGGCCTTCAAACTGAAGCACAGCCATCAACTTCAGGTCTTCAAACTGAAGTACAGCCATCAACTTCAGTGGAAGTTAGTCAGTTAGTTTCGGATTCGTCTGATGATGTACCTGAAGTGACGGATAGTCTTGGGCTCTTAGCTGAGTCGTCGAGGGTGATGGAAGATGATGAGGAACAAGaggatgatgacgatgatgatgatgatttctaTCCAGAGGATGAAAGCAGCAATCAAATGACAGCGGAACATTCAGAAGATTCAAATGCACAGCAATCAGAAACGGACATGAAAGAGCAGGAAGGGAAAGAGACAGACACAGAATCACCACTAGTTGAAAAGGAACAATTCAGTTTTGATGTAGGTGAAACGACAGTGACAGAAAAGGATGGAACATTGAAAGAAAAGGATGGAGAGATCGATGAAGACGAAGTTGTTTGTGAAGATGATGTGGTGACAGACACTATAGAAGATGAGACAGCAACTAACCAAGCTGTAGTTGCTGAAAGTACCAAAGGCACAAAACCTGATGATGAGGTGAAATCAGACCAGTCGAAACAAGAAATAGAAACTGTAAAGCTATCTGATACTTCAGACACGGAACAAGATGTACCGGCTGTCAAAACTGTACCCAGAACAGATACTTCTAAAACTGATAAAAGCGAAGCAGTCAAATCTTCGCCGGCCAAGAAACTAGAATATTCAAAACCGGGAAAAGTACTTAACTATGTTGACCTGGAAGAGAGTTCCGAAGATGAAATACAAGAGGTGAAAAAGGATGGTCCCACACCAGAGGCTGTTAAAAGTACCACCATCACAGTGGAGGAAGGCAACGTGGTAATACCATCAGAGGTGGAAGTCAAGGCTTCTGGACCTGAAGAGAAGCAGagTGATTCCACTGCACAGAAAGAAGTTACGGTTGAAACCCCCAGTACTACAGAAACTCCTCAAGATGAGAATAAGGCTTCAGAAGACACTTCTAAAGCTAAGCATAAATTCAGTCTGGAAGTGTTTAGTCTGGATTCAGATGAAGAGGATACTGAACCACAACCGCCAAAAGAACTTACAGGGGTAGAAATAGACAAAGCGAGAGAGAACAACAAATGTATCAACCTGTCCTGTACCTCGACCACTACGGTGTACTATACCGCCGATCCGTCTACCGTCTCTTACTACGACGCTGAGAGAAAGAGAAAGGCTATGGTGTGCGAGGAGTGCGCTGAAGTTGTCGCTAGGAGGGCGAAGAGCCTAGTGGACGGCATAAGAGAGCTGACGCCCCTCCTGTCCCTGGAACCGGCGCGCGCGGCGTCAGAACTGGTGGAGATCTCCGACTCCGACTCCGACGCCGGCGCAGACGACTCGAGACCCGCCCTAGACGCGATAGGACACAGCGGCGCACAATTCATAGAGAAAGAGTTGGCGAAGACGCTGAATGAGACGTGGGTGAAATACAACCTGGACTCTCGTCTGACTGAAGCTCAGGAGGAACTCCAAAAGGAGATGAAGAAGTTGGAAGAGGAGACAAAAGAGATTGACGCGTTACTAAGCGAGTGTCAAGTGGCGACGGATCAGCTGCGTAACGAGCTGTACGCGACCTTCGAGCAGGAACGACTCGAGCTTAACGCGCTTAGTATACACGATACCCCGGGAAATAAgACGCGAGCGAAACGGCGTTTGTCTTCTGCCAGTGAAATAGCTCCTAAGAGAGCGGCAATACCATTAGGATACACGCCTTTAGACGGTGACAAATCTGCGTCTCAGGAATTCAAGAGTGAGCCGACTGTTGAAACCACAAAGGCAGATGATGACAAAGACATAGCAGTCCTCAAAGTATCAGCCGAAGCCGCTCCCTCCGACCTCCCCCCTCCGGGGGAGGTGATCCGTCCCCCCCTAAAGGCGGACATGCAGGTGTATGCGATGAGGAACACGTTCGGTTCCTGGGCGAAGGCGAAGGTGCTGGAGGTGCAGGGGAAACAACAAGTGCCAGGGGCCTCGCAGAGCTTCACGATATGCCGCGTGAAGCTGTTCTCCCGAAGCACGACGAAGACGAAACAGCTGCCCGCGCGCGGCCTGGCCTACTCCTCGCCCGCCCCAGTCAGGATGACCATCGGTACGAGGGTGATAGCGCTATTCAAAGACCCCATGAACGATTTGAGGAGAGAGACGTTCTACTCCGGAATCATCGCGGAAGTGCCTAACCCTGTTAACAGTTACAGATACCTAGTGTTCTTCGACGACGGCTACGCGCAGTACGTGCGGCACCGCGACACGCGGCTGGTGTGCGAGTGCTCCCCCCTCGTGTGGGAGGAGGTGCACCCTTTCTCCAGGGAGTTCGTGCGGAAGTACCTCATTGCCTACCCGGAAAGGCCGATGGTGCGATTGCATGCTGGGCAGAGTTTGAAGACCGAGTGGAATGGTAAATGGTGGACCTCCCGTGTAATCAGCGTGGATGCATCTCTGGTGCAAGTGCACTTCGAAGAAGACAACCGCACAGAATGGATCTACCGTGGTTCCACGCGCCTGGCGCCGCTCTACCTCGAGCTACAGGCCGCGGAGAGGCACCGCGCAAGGCCTATGCCCCGGACTAAGGCACAGCCTAGGGTCAACATGCCGTACGTGGAGTACACTCGTTCGGACGAGCAGTCCAAGCCTGACCAGCAGGCTATGCCGCCCCGCACGATCGCTGCACAAGAGAGGGAGAGGGAGATTCGCCAACGAGCCGTAGCCAAGAAATCGACAGCTGCCCCGCAACAGCCTCCCGCCACGCACACTGAATCCGTCACCAGCCGAGTTGTGTACTACACACCAAAGAATGCAGTGAAGCCGTATAAAATGACGCCACACACCTGCGGCCCGCATTGCAAGAGGAACGACACGCTCGCTCTCAAAGACCTTAGGACTTACAACCCGCTTGCGAAACCCCTGCTTAGCGGCTGGGAAAGGCAGATAGTCCGCTACAACGGTCACAAGGAGGTGATGTACCGCGCGCCGTGCGGCCGCCGCCTGCGCTGCATGCGCGAGTTGCATCGCTACCTGCGCACGGTGCAGTCTGACCTGCCCGTCGACCTGTTCGACTTTACGCCGCACACGCATTGCCTTGCCGAGTTCGTGCTTAATAAGTGCCTCGTCGGGAAAAAGGACCTTTCCCACGGCAAAGAGAACGTGCCAGTCCCATGCGTGAACTACTATGACGAATCGCTACCCGAATTCTGCTCGTACAATACTGAACGGACGCCCACAGCTGGAGTGCCACTCAACATTGACCCTGAGTTCCTGTGCGGGTGTGACTGTACTgacgattgtgagGACAAGACGAAGTGCGCCTGCTGGAAGATGACGCTAGAGGGCGCCCGAACCATCGGTTTGGACTGGAGGAAAGTCGGATACGTTTATAAGAGATTGCCTGAGCCACTGCCATCAGGAATATATGAGTGTAACTCCAGGTGTAAATGTAAGCAGACATGCCTCAACAGAGTGGCACAGCATCCGTTACAATTAAAACTACAGGTTTTTAAGACGCTGAACCGAGGCTGGGGCATCCGAGCTCTAAACGACGTGCCCAAGGGCTCTTTCCTGTGCGTGTACGCTGGCAACCTACTGACTGACGCCACCGCCAACATGGACGGTCTTAACGAAGGCGACGAGTATCTCGCCGAGTTGGACTACATCGAGGTGGTGGAGCAGATGAAAGAGGGATATGAAGAGGACATTCCCGAAAAGGACAAGAAGCTAGATAAGAAACACAACGAAACCCCTGAAGAACCAGAGATGTCAAGTTCTGATGAGGAAGAGCCGGTTTCCAAGAACGAGCAGGAGGATGGTGACTTCTGTCCAGGTTTTATTGGAATGGGAGTCACGGAATTCAGCAAACGTCTTCGGAAACGCGACAAAGGcaagaaagagaaagaagaaCCCACTGTGAAAGAGAAGGAAGAGAAACCTGATGAAGACTGCATCACTATTAGTGATGATGAAGAAGTTCGGGAGCCAGCCAGCTTCATGGCGCAAGCTGGGATGGAGTCAAGTGAATTTGTATCTAAGTATAAGTCCGTTCGTTCGTTATTCGGCAAAGATGAAGCTTGTTACATTATGGACGCTAAAGTTCAGGGAAACATTGGCAGATATCTCAatCACTCGTGCATGCCGAACGTGTTCGTGCAGAACGTGTTCGTGGACACGCACGACCCGCGCTTCCCGTGGGTGGCGTTCTTCGCGCTGTCGCACATCAAGGCCGGCACCGAGCTCACCTGGAACTACAACTACGACGTGGGTTCGGTGCCCGGCAAGACGCTGTACTGTTACTGCGGAGCGCCCAACTGTAGGGGACGGCTGCTGTAA
Protein Sequence
MSSDQGDQTLKDNEDILTNSPDTGEKGNLSQIESSDLVDHSVSPTPKYDQIEPLKEGLDVISAKSNTDSGFKDPGAGPTDKTDFDTSSDDEDLHLKWEDDETEEQAEPVPKEVDKNVSKALDEDEGVTDEALDENLLLESPEEADKMDVSVNPEGKPEDLQEPETNVVDIDKLLKSDDDDITDESKTTKSEPELNTNILEMTPDSSDKTTVKETNVKSNENEDSIDKGTLNTAPVEEIKENIAGKETTDMPITDTNNKDESAIEETNVKSIEKEDSIDQEIRNTAPVEEIKEIIAGNVSGKETTDMPITDTHNKDESVTNDSIIATSSPNESFSNTTIDAISDHRLNKPDAMLEIPTQEVIDILDDTDISIADADNTEMENSLKSQQTEDAKVDTIDVTDKTIETVQLQSKEEQTIELDSAVFEVDLKEQVTVQTSTVSEDDWSEIERKLKGFETSLVEDSGSKVEVKTSAEDSESKIDSTKAESNKSPNAEILESKELEKSREDNSKTDTNQQPNESSEVRELGEVPKPASPIHKPKLKLRDIGSLLAKPITTSAEIINIDESSLTEFPETLYKSIDLISEDSNDKTISDKLDSISLIKAQSSEEMLIESMTDVNILPDIDSHPTEDLNMDVDEEPSNSEVDVEKTASLFDTVIKIDDSTKSISKMDVDAENIEPTIQSSSQQLENLTISKDNEVPTNVTSDPLTLEGTTTIIEVQPSTLIKVISKSSTSEADEVQPSTSGLQTEAQPSTSGLQTEVQPSTSVEVSQLVSDSSDDVPEVTDSLGLLAESSRVMEDDEEQEDDDDDDDDFYPEDESSNQMTAEHSEDSNAQQSETDMKEQEGKETDTESPLVEKEQFSFDVGETTVTEKDGTLKEKDGEIDEDEVVCEDDVVTDTIEDETATNQAVVAESTKGTKPDDEVKSDQSKQEIETVKLSDTSDTEQDVPAVKTVPRTDTSKTDKSEAVKSSPAKKLEYSKPGKVLNYVDLEESSEDEIQEVKKDGPTPEAVKSTTITVEEGNVVIPSEVEVKASGPEEKQSDSTAQKEVTVETPSTTETPQDENKASEDTSKAKHKFSLEVFSLDSDEEDTEPQPPKELTGVEIDKARENNKCINLSCTSTTTVYYTADPSTVSYYDAERKRKAMVCEECAEVVARRAKSLVDGIRELTPLLSLEPARAASELVEISDSDSDAGADDSRPALDAIGHSGAQFIEKELAKTLNETWVKYNLDSRLTEAQEELQKEMKKLEEETKEIDALLSECQVATDQLRNELYATFEQERLELNALSIHDTPGNKTRAKRRLSSASEIAPKRAAIPLGYTPLDGDKSASQEFKSEPTVETTKADDDKDIAVLKVSAEAAPSDLPPPGEVIRPPLKADMQVYAMRNTFGSWAKAKVLEVQGKQQVPGASQSFTICRVKLFSRSTTKTKQLPARGLAYSSPAPVRMTIGTRVIALFKDPMNDLRRETFYSGIIAEVPNPVNSYRYLVFFDDGYAQYVRHRDTRLVCECSPLVWEEVHPFSREFVRKYLIAYPERPMVRLHAGQSLKTEWNGKWWTSRVISVDASLVQVHFEEDNRTEWIYRGSTRLAPLYLELQAAERHRARPMPRTKAQPRVNMPYVEYTRSDEQSKPDQQAMPPRTIAAQEREREIRQRAVAKKSTAAPQQPPATHTESVTSRVVYYTPKNAVKPYKMTPHTCGPHCKRNDTLALKDLRTYNPLAKPLLSGWERQIVRYNGHKEVMYRAPCGRRLRCMRELHRYLRTVQSDLPVDLFDFTPHTHCLAEFVLNKCLVGKKDLSHGKENVPVPCVNYYDESLPEFCSYNTERTPTAGVPLNIDPEFLCGCDCTDDCEDKTKCACWKMTLEGARTIGLDWRKVGYVYKRLPEPLPSGIYECNSRCKCKQTCLNRVAQHPLQLKLQVFKTLNRGWGIRALNDVPKGSFLCVYAGNLLTDATANMDGLNEGDEYLAELDYIEVVEQMKEGYEEDIPEKDKKLDKKHNETPEEPEMSSSDEEEPVSKNEQEDGDFCPGFIGMGVTEFSKRLRKRDKGKKEKEEPTVKEKEEKPDEDCITISDDEEVREPASFMAQAGMESSEFVSKYKSVRSLFGKDEACYIMDAKVQGNIGRYLNHSCMPNVFVQNVFVDTHDPRFPWVAFFALSHIKAGTELTWNYNYDVGSVPGKTLYCYCGAPNCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-