Basic Information

Gene Symbol
ZNF526
Assembly
GCA_029286785.1
Location
JAGSMX010000001.1:2181190-2204799[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 6.4 5.2e+02 1.9 0.2 2 22 506 526 505 527 0.81
2 18 0.0086 0.69 10.9 0.1 1 23 537 560 537 560 0.95
3 18 0.14 11 7.1 1.0 2 21 689 708 688 709 0.93
4 18 0.036 2.9 8.9 3.8 2 23 773 794 772 794 0.95
5 18 2.8 2.3e+02 3.0 1.6 1 23 806 830 806 831 0.89
6 18 3.3e-05 0.0027 18.5 0.3 2 23 837 860 836 860 0.97
7 18 0.071 5.7 8.0 0.2 1 23 866 888 866 888 0.93
8 18 0.0022 0.18 12.8 3.3 1 23 894 916 894 916 0.98
9 18 0.92 75 4.5 0.0 2 19 927 944 926 947 0.85
10 18 0.072 5.8 8.0 0.1 1 23 1019 1041 1019 1041 0.97
11 18 2.1 1.7e+02 3.4 7.2 1 23 1048 1070 1048 1070 0.95
12 18 0.0014 0.11 13.4 1.8 1 23 1111 1134 1111 1134 0.95
13 18 0.0034 0.28 12.2 0.8 1 23 1141 1164 1141 1164 0.98
14 18 0.063 5.1 8.2 0.1 2 23 1186 1208 1185 1208 0.95
15 18 0.0039 0.32 12.0 3.0 2 23 1234 1256 1233 1256 0.94
16 18 0.0012 0.096 13.6 0.2 1 23 1268 1290 1268 1290 0.96
17 18 9.4e-05 0.0076 17.1 0.1 1 23 1296 1318 1296 1318 0.98
18 18 0.0009 0.073 14.0 0.9 3 23 1326 1347 1324 1347 0.94

Sequence Information

Coding Sequence
ATGGACCAGCAGCTTCCACCATTAATACTTTGCATGGAGAACATGAATGGAGAAGAAGTTACACTTAGCATTGAACCAAATGATGATTTTCAAACCTTTTTGGACAAAGCCAAATCCACACTAGGATTTGATGTAGACATTAACACCATCACTGGTGATCAATCTGTTTccttaaatgaaaatatttatcattaccTCCTTAATTCAGAACTAAATTTCCGAACCGATCCAcaattaaatacacaaaatttCGACCAGACATCTGATCAAGGCGCACACAGCCCTGACGGATTTGTGTACGTTTTAGATGACGGCACACAAATACGAGCCTCACAAATACATTTCGATAACGAAGATCCTCCTGTAGACCTAACAGCGGAACAAATACCATTTGTCAAATACGCAAACGATAGCGCAGATGAAAATGAAGCCGAAAGCGATTTGAATATTGAAGACACGAAGAAAATCAACATTgttgaaagtcccgttaaacgTTGGGCGAGCAGAACTGCGAGTCCTAAATGCAGTTTCGTCAACAGTTTACCTTTCAAACTTGTCTGTTCGAACACATCTAATTTCGAAGCCCAGTTTACCAAATACTTAGAATCGAGCAGTTCAAAAACGTTCGCAACTTTGAACCCAGTTGCTATTAGAAATAGATCCCCAAGAAGCTTAATTAAGGACAATTTCAAAAATTACGATGAAAACTATCAGGCACAGCATAGCAGAGATGATTTTGCAAGTTTTACACGTGAAGAAATCCTTAATATGTTTAAAGATTCTCCCGTTACATCCTTACCTTACGAAGAGAATCAAAATCATAACGAAAAAAGACGTCATGTCCGCAAAACCGACCCCTCACGACTTCATAAAAGTTGGAACCATAGGCCCTTAACCTATATAGACGTAAAACCTGGGGACAAAGGTAGACAAAATTGTTTCATCTGTGGAAAGATCGATAACAACGTGGAAAagctatatttatttgataatgaaGATCAAAAGCTACACAGATGTACATCGCCAAGAAAGCATCCCACTCAACTCAAAATTATATGCGACCTCTGCTTATCTGAAAATTTTAAACCAAGCCGTATGAAAAGTCCAACCCAATCTCTTACTTCCGATGAATATttggttattaaaaataaccaacaatttatttttcaaaaggtAATTGACTTTAAAGAAGCTCAGATAGCAGAAATCACAGATAAAATAGAATCTCAGGATTTTAAAGAACCACTAGAAAGCGAAAAACTTGAATATGTGAAGGTAGAAATAGGCTCCGATGGGGAAATAGTTACTAAATGTATAGACAACGATACGCGATCTTCCGATGACGTTATAATTGTAAAAGatgagaaaaaagaaaattccaGCGACGTAGAAATCATAGAAAACGATCAAGATATCGATGATCACATAATAGATAACTTGGAGGAAGCCGATGAGGATGTTAAAGAATTCTTGGGAAAATATCATTGCGACGATACCAATAAACTAATGGAATTAAAatgcagGTTCTGTGAACGTGTGTTCGAGGAAATTGTTCACGTGATAGACCACGGTGAAGAGCATAAGCATAATTTAGATGATGGAGAAGTTTTCCCGTGTCCACTATGTGATTACGgttATGCTAATTTTAAATGGTTGAAAGGGCATCTTAAAGCAGCTCACGATAAAGTACTCGGGAATACTCCTGTACTCGACAAAGATGCTACAGGGGATGGCAGCAACGatGCTGCTACTACGTCTCCGAGCTCGTCTCCTGTGGCTAAGAGAACTAGGAGTGCAATTAGAAAAGTTGAAACCGAGAATGAAAAAGAGTCCCCGGAGAAAACATTAGAAGGCGCCAATAATTTTACTTCAAGGCTAGAATCGAACGAGTCTACGCTGACCGTGAAGACTGAAGTGAAACAAGAGTGCCTGGACAGTAGCGATGATGAAGCAATATGGATTGTGCAGACTGTCGGCCACGAGGCTTCGGACCAGCTGGAGAACCTTCTTAAAGTCGCCACGcTTGACGATAAGGACAAAGAAGGGAAATCGAGAAAGAAGAATAAATGTAATAGCTGCAGTCAAATATTCCCTACCGCCGAGAGCTTAGCCACTCACAAGTGTCGCCGACGGGGGAGGAAACGTAGGACTCCGGCGAAAGACGACTCGGTCATTTGCGTTCCATCTGAGGAGGACTTTTTCAGGAGGGCACAGGGAAGACCTCGACAAAAGCAAGCAGCGGTTGACAACGATCTGCTGGTGGTTAGACCTCGTAAGAGAAGAAACCGCGAGCCGACCTCCGACCCGCAAATTGTCACCTGTCACAACTGCAACGAGTCATTTACGTCTAAAGTTAGACTGAAGTTTCATATGCAATTCCACGACACCACCAATCTACTGACCTCCGATGGTCGATACGCGTGTCCGGAGTGCGAGGGAGCGCACTTCCCCACCGAAAGCGAGCTCTTCGATCACGTGCACTTCCAGCATCACAAGCAGAAACGCTGGCAGTGTCCCGTCGAAGATTGCGGGAAGACTTTCTATTTGAGGGCGACTCTGACGAAACACAGCCGCACTCATACGGACACGCGGCGGTACGTGTGCGTAACTTGCGGCAAGCGCTTCCTTGACAAGCAGACCCTGGATGAGCACGGCGTCACGCACCTTCAGATAAAACCTTTCCAATGCCACATCTGCTTGAAGCAACTGACTCGTCGCTCCAGACTCCGCATGCACCTGCGCGCCCACGAGGAGGAACTGTCGCCGCGGCTGGTGCTGGTGTGCACGGCGTGCGGACGCGCATTCAGGGACACCAACGACGCTGAGGATCATGCTATCAAATCAAAGCAGTGCATAGAGAAGCTAAGTCCGGCTGTAAAAGAAGAGAACGAAGTGGCAGTTCACCTATCTCCCACCAGTGGCCTGGTCACTCACACTGTGGCAGTTGTTGcGAAGTCGCCACAAATGGACTGCGGACCGGACGGCGATGCTCTACTGGCAACACTCACTGACTTTGCGAGAATAATCATCCGAGTTGTCGAGATCGAGAAAGCTTTTCGTTGCGAGTATTGTGAAGATGTTTTCTACTTAGAAGAAGCACTCAACAGCCACCGTATCATCCACAAGGGCGTCAAGAATCCATTCACCTGTCACATTTGCAAAGTTAGCTTCGCTACTTATTCCAGATGTACCACCCACAAAACAACCCATGGTTTTTATAAGCGCTCTCTCGCTGACTGCAAGAAGTCCGCTAAGAGTCCCGGCTCATCGGAAGCTGGACCGGCGGCAACGGGCATACTTGGATACGGAGGGTTTCCTGTTGTCAAGCATTTTTTATGCGAGGACTGCGGACGGTCGTACCTGCACTGGACTTACCTCCAAGTGCACCGTCGCATGAAACACGCCAACGAGAACTACCTCTATAAGTGTAACCAGTGCGAGCTCACCTTCCCAAACAGTTGGAGCGTGGCGTATCACAGAAAAAAGATGCATGGGAAGAGTGGTCCCGAAGATGGCGGAGGCACTACTAAAATAGCGAGGGACGATTACAGAATACCTTGCCGCGACTGCAGCGAGATGCTGCCGAACAAAACTGCACTTTATGCACATAGACAAAAGGAGCATAGTGATACAATGCTGTCAATGAGTGATGAACAAGGTACGGACGCGCAAGTGCGTACGCACGCGCCTCGCGCTACTTCTTGCTGCAAGTGCGGCCACAACTTCACCGAACCCAACGCTCTGCAACGTCATCTCAAAGAAGTGCATGGACATGAGAGCGAGGTGCGCACGGGGCGTGCCCACGCCTGCGCAGTGTGCGGGCGCGTGTTCCGCTCCGCCTCCGTGCGCAACGAGCACTTGCGCGTCCACACCGGCGAGCGGCCGTACCCGTGCGACGTTTGCGGCGTCGCCTTTCGACGATCGACAGCGATGCGAAACCACCGACTGATTCACTCCGGCGTGCGCGCTTGGGCGTGCATGCGCTGCCCCAAACGGTTCCGCATTCGTTCGGACCTGCGCACGCACTTGCGTCTTAAGCACCCCACACATCTCGTCGTGTTTGAGGTCAAAGGCTTAAACCCCACGTATGAAGAGATAATGCAGCACATCCGCGATCACAATATCACCGATGGCCGGGTCATCGAGATAacaaaaatttcatttaaagaGGGTACTACGAGTATAGTGCCGACGAGCGCGCGCGCGTTATCCCTACTCAGTGCAGTGCCGCGTACAAAGATAACGTGCGAGCCGCCCACACCACTGAGCATTGATATGTTTCAACCCGCACGCCGTGGAAGAGGTATCGCCAAAAACCCAAGGAGACCTAAGATTCTGCAAGGACCCCACGACGAGGCGGAACTAGAACCGATTGCATATCCGCTACCTATTGACGCAGATGGAGAGGAGTTGGGAGACCTGAATGTCCAGCTGCTGCTGCGTGATGAAGCGCTGAATAACAGTCAGATGGTGCAGCTCCAACTGGATGAGAGTATCTGGAATAAGCCACAGTGA
Protein Sequence
MDQQLPPLILCMENMNGEEVTLSIEPNDDFQTFLDKAKSTLGFDVDINTITGDQSVSLNENIYHYLLNSELNFRTDPQLNTQNFDQTSDQGAHSPDGFVYVLDDGTQIRASQIHFDNEDPPVDLTAEQIPFVKYANDSADENEAESDLNIEDTKKINIVESPVKRWASRTASPKCSFVNSLPFKLVCSNTSNFEAQFTKYLESSSSKTFATLNPVAIRNRSPRSLIKDNFKNYDENYQAQHSRDDFASFTREEILNMFKDSPVTSLPYEENQNHNEKRRHVRKTDPSRLHKSWNHRPLTYIDVKPGDKGRQNCFICGKIDNNVEKLYLFDNEDQKLHRCTSPRKHPTQLKIICDLCLSENFKPSRMKSPTQSLTSDEYLVIKNNQQFIFQKVIDFKEAQIAEITDKIESQDFKEPLESEKLEYVKVEIGSDGEIVTKCIDNDTRSSDDVIIVKDEKKENSSDVEIIENDQDIDDHIIDNLEEADEDVKEFLGKYHCDDTNKLMELKCRFCERVFEEIVHVIDHGEEHKHNLDDGEVFPCPLCDYGYANFKWLKGHLKAAHDKVLGNTPVLDKDATGDGSNDAATTSPSSSPVAKRTRSAIRKVETENEKESPEKTLEGANNFTSRLESNESTLTVKTEVKQECLDSSDDEAIWIVQTVGHEASDQLENLLKVATLDDKDKEGKSRKKNKCNSCSQIFPTAESLATHKCRRRGRKRRTPAKDDSVICVPSEEDFFRRAQGRPRQKQAAVDNDLLVVRPRKRRNREPTSDPQIVTCHNCNESFTSKVRLKFHMQFHDTTNLLTSDGRYACPECEGAHFPTESELFDHVHFQHHKQKRWQCPVEDCGKTFYLRATLTKHSRTHTDTRRYVCVTCGKRFLDKQTLDEHGVTHLQIKPFQCHICLKQLTRRSRLRMHLRAHEEELSPRLVLVCTACGRAFRDTNDAEDHAIKSKQCIEKLSPAVKEENEVAVHLSPTSGLVTHTVAVVAKSPQMDCGPDGDALLATLTDFARIIIRVVEIEKAFRCEYCEDVFYLEEALNSHRIIHKGVKNPFTCHICKVSFATYSRCTTHKTTHGFYKRSLADCKKSAKSPGSSEAGPAATGILGYGGFPVVKHFLCEDCGRSYLHWTYLQVHRRMKHANENYLYKCNQCELTFPNSWSVAYHRKKMHGKSGPEDGGGTTKIARDDYRIPCRDCSEMLPNKTALYAHRQKEHSDTMLSMSDEQGTDAQVRTHAPRATSCCKCGHNFTEPNALQRHLKEVHGHESEVRTGRAHACAVCGRVFRSASVRNEHLRVHTGERPYPCDVCGVAFRRSTAMRNHRLIHSGVRAWACMRCPKRFRIRSDLRTHLRLKHPTHLVVFEVKGLNPTYEEIMQHIRDHNITDGRVIEITKISFKEGTTSIVPTSARALSLLSAVPRTKITCEPPTPLSIDMFQPARRGRGIAKNPRRPKILQGPHDEAELEPIAYPLPIDADGEELGDLNVQLLLRDEALNNSQMVQLQLDESIWNKPQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01149010;
90% Identity
-
80% Identity
-