Mbor006352.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Marronus borbonicus
Gene Symbol
MBD-R2
Assembly
GCA_902655005.1
Location
LR737380.1:14989735-14997175[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.1e-15 9.9e-12 44.4 0.0 8 75 398 464 394 466 0.92

Sequence Information

Coding Sequence
atgggtCGTAAATGTGGAATATCAGTGTGTATGTCAGACTCAAACAGAGAAGAAGATAGAGGAGTGACCTTCCATAAAATTCCGATGCATCCTGATATTCGTCCCAAATGGATGTCTCTTTGTCGTATACCGGAggataagaaatttatgaaagttaTTTATGTGTGCTCTCGGCATTTTTTAAAAGTcgatttttgtcattttaaaggCAAGAAGTATATGTTAAGGCAAGGTGTACTGCCTAGTGTATTTCCttggaataaaaataagattgaAGTAAAAtctgacaaaataaaaagtgaaattgGGGAAATCGACAAAAATGACGGAGGTAATGATAAAGAATGCCCTAAGAATGAAAGCGAATCTGAAATTGTATCACAAATAAAGTTTGAGGTTACAGAACAAGATTTTAATGCCAGCACATCATTGGCATTGAAATCCGACGAAGATATTTTAGATATGgcaaatttgaaagaagaagTTGTAAGTCCTAATCAGTCAACAACTATTGAACAGAAAGTGAAAACAGTTGAAACAGCAACTGGTCCCCTAACATTTGCACCGAATACAAGAATTGAAGCATTAGATTTCAATCAGTCTTGGTGTCCTGCGCTAATTGTTGAAGTAGATTATCAAGAAAATGAAGTTTTAGTTCATTTTGAGAAGTACTCGAATAAATATGATGAATGGATATGTATGAATAGTTCAACATTAAGATCATTGTCTACAAATGctagtaaaaaaatagaaacctatGAAGTTGGTGAAAGATGCTTAGCAACTTGGAATAATGCTAAGAAGTTTCCAGCAACTGTctcaaaaataattgataaagatatataTGAAGTGCATTTTGATGATgactttgtaaaaattttgaaagcaCATAGAATGTCAAAAGCTACAGGTAAAGTGTTGCAAGCTTCTCCATTATTTGATCCTGTTACTGGAACAAAGCAAGAAAGACGGGAtcgcaaaagaaaaataaatgttgccGCTTTATTTGGTAAGAGACCACGAACCAATAGTCAGGAAGAGATAGCGACTTCTAAGGGGAATGACAATTCTGTCGCCGGTTCTTCAGAAGAGGTAGAAAGTTGGATACCCaaATGGGAAGATGGCAGACCAATTGGTGAAGATTCAACAATAGAGACTATAGATGGCCCAAGGCTATCAGTTATAGTTCCAGATCCTCGTTTACCACCACATTGGGTAAAACACTTAGCACAACGAAATCATGGAACTTTAGCTGGCAAATGgaattcatttataattaatccAGATGGCCGGAAATTTAGAACAAAATCGGAAATAAAGGCGTACATTGAAGAAAATCCCGAATTGAACTTGGCAGAATCAatgtttgatttttcaatttctaagaAGTCTAGAAGAAGTACATCAGAGAAAAAACATCTCCCAACACCAACAGAACTTATGCCACGTGATCACTCTCCGTCGGAATCACCAAACGACGAAGAAATCGTTGCAGAACTTCccaactatttaaaaattcctgTGGTGGATAATGCTTATAAATGTCCAATTGAAGGTTGCGGCAAGAACTTTCGGAGGGAAAATCTGGCACAAATGCACGTTAAACATTACCATCCAGAATATACAAAATTCTTAGATTCAACTCCAAACGTTGCCGATTTGGCTTACGCTAGAACAGTTGGAGAATCCCTAGATAGATCACCCAGTCAAGATAAACCAAGGACACCAGCACCAAAACCaacacaaaaaattcaaaatccaaAAACAATCATTTCAAGAACTACACAATCACCTTCATTTGAAATCGAACAGCAACACGCTGCAAAGGTTAGAGATtcggaaattataaaattattaagtagTAAACCTAATGATGGTATTAAAAAAGAGGATCAAAGATCGCAGTCACCGATATTACCGTCTGGTTTACCGCCCAGTATGTATCCTGATATCAAGCTAAAAGATCTATTGAATAAATCTGAAGCCATACCAAAGAGAGACGACATCAATTTGAAAACGTTAAGTGCAAGCACGCAAAGACCTACAGGTATAAAAACTTTGTTACCAGTAACACGAATAGAACCAaaagtagaagaaaaagaatcagaaaataagttatttttgaataaaaatgtaataggaAAGCATACAGCTAAGCGTAAACGTAATGCTTCTGAAAATATTGAAACTCCACCAAAACCTAACAAAGAACTGGTTGATACTGTTGTTAAACCAGAACCAGCTGTAGCCGAGCCTTCGAGTAACGTTATAATTGAAGGCGGCGAAGTtataaaaattgtgcaaatgAAACGggaagaaataattaactgtACATGTGGTATCACAGAAGAAGACGGTCTTATGATTCAGTGTGAATTATGCTTATGTTGGCAACATGCATACTGCAACAACATTGAACGTGAAAGTCAAGTTCCGGAGAAGTATATTTGTTACATATGTCAGAATCCAGCAAAACAAAGATCTTCCAAAAAGTATTTGCACGATCAAGATTGGTTGAAACACGGTACTTTGCCAGTTGGAAATTACCATTGTAAAGATGAACAGGTATTAAAAGAAcgtattgaaaaattgaagaaaacccATGACCTATCTGGTGCTCTATTGGAGCTTAAGGATTATATGCATACACTTcgagtaaaaacaaaaatagctCAagCTAAAAATCATCCAAAATCGTATTTATGGTCCAAACCATGGGAAAAGTTACCTTTACCGGAAAAGATGGAACTAAAAGATGAGAATGAGAACACAAAACAGGAAGATGATCATCAGTACAGCAAAAATGACGAAGCTGGAGATACTGTTCTCTTGTCGTTATTAAAACCAGTTAAGGACGAAGTTTCTGACGTTGCAGAGTTTCCAAAATTAGATTTAAACACTCTCATAGAGAATAACTTAGATCCAGTGCCTGTTAATACATTAAGAATACCGCAACCAGAAGCAGCAATAGATTTGGCAGATTGCAAATTGAATCTATTGGAACATATCCAGCATAGTCAGTCATTGGTAGAAGAACGATTGAATGACTTTGAAGAGCAAATAAATAAGTTGGAGCCATTACTAGATGAAGAGGATAATGAAGATTACCCGAGATTGAGACAGACAACGCAAATGTTGATGAGAGATCTGACTGTGTTTAAAGAATTGTCGCTGATGACTACTTTCTAG
Protein Sequence
MGRKCGISVCMSDSNREEDRGVTFHKIPMHPDIRPKWMSLCRIPEDKKFMKVIYVCSRHFLKVDFCHFKGKKYMLRQGVLPSVFPWNKNKIEVKSDKIKSEIGEIDKNDGGNDKECPKNESESEIVSQIKFEVTEQDFNASTSLALKSDEDILDMANLKEEVVSPNQSTTIEQKVKTVETATGPLTFAPNTRIEALDFNQSWCPALIVEVDYQENEVLVHFEKYSNKYDEWICMNSSTLRSLSTNASKKIETYEVGERCLATWNNAKKFPATVSKIIDKDIYEVHFDDDFVKILKAHRMSKATGKVLQASPLFDPVTGTKQERRDRKRKINVAALFGKRPRTNSQEEIATSKGNDNSVAGSSEEVESWIPKWEDGRPIGEDSTIETIDGPRLSVIVPDPRLPPHWVKHLAQRNHGTLAGKWNSFIINPDGRKFRTKSEIKAYIEENPELNLAESMFDFSISKKSRRSTSEKKHLPTPTELMPRDHSPSESPNDEEIVAELPNYLKIPVVDNAYKCPIEGCGKNFRRENLAQMHVKHYHPEYTKFLDSTPNVADLAYARTVGESLDRSPSQDKPRTPAPKPTQKIQNPKTIISRTTQSPSFEIEQQHAAKVRDSEIIKLLSSKPNDGIKKEDQRSQSPILPSGLPPSMYPDIKLKDLLNKSEAIPKRDDINLKTLSASTQRPTGIKTLLPVTRIEPKVEEKESENKLFLNKNVIGKHTAKRKRNASENIETPPKPNKELVDTVVKPEPAVAEPSSNVIIEGGEVIKIVQMKREEIINCTCGITEEDGLMIQCELCLCWQHAYCNNIERESQVPEKYICYICQNPAKQRSSKKYLHDQDWLKHGTLPVGNYHCKDEQVLKERIEKLKKTHDLSGALLELKDYMHTLRVKTKIAQAKNHPKSYLWSKPWEKLPLPEKMELKDENENTKQEDDHQYSKNDEAGDTVLLSLLKPVKDEVSDVAEFPKLDLNTLIENNLDPVPVNTLRIPQPEAAIDLADCKLNLLEHIQHSQSLVEERLNDFEEQINKLEPLLDEEDNEDYPRLRQTTQMLMRDLTVFKELSLMTTF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00956361; iTF_01123724; iTF_01123781; iTF_01120916; iTF_01120877; iTF_00434204; iTF_00434118; iTF_00307902; iTF_00307990; iTF_01498942; iTF_01498888;
90% Identity
iTF_01120916;
80% Identity
iTF_00956361;