Mjur010967.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Maniola jurtina
Gene Symbol
MBD-R2
Assembly
GCA_905333055.1
Location
HG995211.1:3988644-4004058[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.7e-17 1.5e-13 50.6 0.1 5 67 809 870 805 875 0.91

Sequence Information

Coding Sequence
ATGGCTGTAAAAAAATGTTCTATAGCGAATTGTAGTTCTACGTTATCAAGCCCTGAAGATATTGGTGTGACTTACCACAAGTATCCTAAAGACACCGGAATACGTGAGAACTGGTTGTCTGCCACACGCCAGACTTATGATAACATTGATAATTCTACATATGTGTGCTCTCGCCACTTTTGTAAAAGTGATTTTAAAGTGTACCAGGACTCAAAATATGTCCTGAAGTCAGATGCTGTACCATCAATATTTTCTTGGAATCCGAATATAAAATCTAACAAAATGGACCCTGAATCAATCACAGAAGCAAATTCTGAAGAACAAACACACAATACTTCATCAAGCAGTAAAGAATCTGAAGAAGAAAATGTGGATGCTATACAAAAATGTATAGATGAACAAGAAATTGAGATACAAAATAAAAGGAATCAAGATGAAACACAAGAAAAGGCAGAAATGGATAATAAACAGAAATCAGAAAATCCAGAAACCCCAGAAAGTACAGAAAAGCAAGAAAATGTAGAAAATTTAGTTATAGAGCAAGTGGAGAATGTGGTATTATGTACAAAAATGATGGACATGATATTGAGTGTATCTGAGGACAAAGCTGATTCAAAAAAGGAAGTTAAACCTATAGCTAAGCAGAGTGTGAGTCCTAAAGGTAATAATAGCATTGCATTGTCAGTGGGTTCAAAGGTGGTAGCCAAAGATTTTGAGGAACTGTGGTACCCAGCTGAAATAGTGGAAGTTGATCATGATGAGATGGAAGTGTTGGTGCACTATGAAAACGTATCCAACAAACCTGATGAATGGATAAACATAAGTAGTCCCAGACTTAGACCTATAAATAAACCATCAACACCAATAGAGACACCAGCATTGACACCTGCAGTCACTGAAGTGGCTCCTCCTGAAGAGCAAGCAGCACCAGCGGAACTAGTTCAGGAGATCAAAGTAGAAGACAAACCGAAATTACATTTTGTAGTGGGAGAGAGATGTTTGGCCCGATGGAGGGACAATCGTAGATTTATTGCCACAATTGCTAATGATTTGAGCAATGGCGTTTACGAAGTCATATTCGACGACGGCTTCCACTGGAAGTGCAATACGTCTCGATTGTACAAATTAAAAGATCCAGGAAAGCATTCAGAGTGTCTATCCGTCGATACATCCATGCCTCCGAAACCCTCTACCCCTTCTCCGGTCCAAGCAGGGGCCGGACCTAGCACCGCATCACCCCTAAATGCACTAACCCCTACCCCTATATTCCATACCCACCTCTTTGACCCCACCCGTGACTATTTAGGTCCTAAATCTGAACGTCGCGAAATGAAACGAAAGTTAAATATCAAAGAGATTTTTAACATCGGTCAAAAGAAAAAGAAAAAGGAAACACCGCCCAAAGAAAAAGTTGCACGAGTTGTAAAAGAAAAGAAACCAAGAGTACTTCTGCGAAAAANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCTGATGCTGTAGCGTCTATCATTGGTACCGTCGCGAAAGAAGACGCGGCAAAACCGACGGTACCCGAAATAAAGACGGAACCAGACACAGAAAAATCACTTGACAGTAGCGAAGTGAAAGAAGAAATTAAACTCGAACAATCTGAGGTACAGGAAGGAAGTGATAAAATTACTTTAGACGATCTGGTTGACAACAGTTCAGTAGCTAGCACAGAAATTGACATACCCTTTGACTTAGATTTGCCACAATCTACACAAGATATGGAACTTGATTTGGAAGAGGAGCTGAAATTAGAGAACTTCGAAAAACCGGACGAAAGTAAGAAAGAGGACATAGAGAAAATGAAGGAAGTCATAAGCAAGCTAGAGGTAGGGCTGATCAAAATCGAAGATGATCACCAGAATCGAATCGATTCTCCAAAACCTGAACCGCAACCGGCATTGAAACCAGAATTGAAACCAGAGCTGAAATCTGAGTCGACACCTGAGCCAGAGATTGAAGTAATAGAAGTCAACCCCGCTGCCGGCGAAGTCGATAAGATTGACAAAGTGGAGCCTCAAGAAAAGTCGAAGAGAAAGTTGTCCAAGATAAAGAAGAGTAAAAAGTTGAGGCTGCTGCAGGAGAAAAAAGTCAAGAAGCAAGTGGAAAAAGTAAAGAGTGAGTTGGAGGAGATGAAACGTCAAGTGGAAGAGATGAGGAAACAGATGCTGCTCAAGACAGAGCAACCCTCGCCGGCTCCGCGCCCCAGCGAGATGCCGGAGAGCTTCCTGCTTCCCGGCGAGTGGTGCTGCAAGTGGCGCGACGGCCAGCCAGTGGGCGCCGTCAGCGAGATCGAGGGCGACTCCAAGATGGACGCCAACAACAAGATGGCCTTGCCGCGACGCAGTGTACAGGTTGAAGACAAGAGATTGCCCGAAGGCTGGTCAAAGCACATGGTACGCCGTAGACTAGGCCAGTCGGCCGGGAAGTGGGATGTGGTACTGGTCAGCCCAACAAATCATCGGTTCCACACTAAAAATGACATGCGTAATTATTTAGAACTGAATCGGAACGAGGAATTGAAACCCTACGAATACGCGTTACTAGATTTTGGGGTGCATCTCAAACTATCCCGACGCATGGGCTGGTACACGACCACTGTCGACGGCAGTTCAGACGCGGTAGTCAACACGCCTGTGAATACCATGTCCCCACTGGCCAAGGCGAAGAAATACCGAGTTTACAGAAAGGATGACAGGAAAGAAAAGAAGAAGAAGAGAAAGAAGCAAATCGCTGCATTCCGACGACAAAATGCGTCCTTGGTTACAACGGCAGGAACAAGTGGCCAAGCATCTATAGGCTCGACAGAATTCGAAGCTACACCCATGGAATATCCCGCTCTAGAAGATGGATATGTATATGTTGGTTCTCTGAAAGTTCAAATACTCGAAAACTTGTTACGGTGCCCGGCCGAGGGCTGCTTTAAAAACTTCCGAAACAACACCTTACTGCAAATGCATATAAAACATTACCATAGAGAACTGAGGAAGATGTTGGGAGCGACGCCGAAAGTTCTAGATTTAGCACAGCAGAGAACATTACCTACAGAACCGGAACCAGTTAGACAGCTGGATTCCAGAATATTGAAAATTAAAATAACGCGACCTCCGAAACGTGCCGAGGAGCCTAAACCGGAGCTAAAGGTGTTCTCCTCTGAAATAAATGTCAATGTTGAGGCTGCGACTCCGACAAAAACGGATCTGCCAATACCAAGATCACAAGATTCGCCCAAACTTCGTGAAGCATTAGCTAATAAGCCGGTCAAAAGACCTAAAGTTTTACTACCGGTCCGTCGACCAGATCCTGAGCCGATTCCTGACGAATTTGAAGAAGAATCTCCAGCTCTTACTTACGATGACGACACTATGGAGTCTACGATAGAAGTAATGGAACCGCAAGACTTCGAAACTGCAATCTCCACGCATACCGTCACAAAACCGATCGACGCTTTTGGAAAGAAGGCGGAGAAGAAACGCAAATGTTTCTCGACTGTTCCTAGGAGACCGGCCAGTGAGGAAGACGAATGGTTCGGAATGAATTCTGATGTAGAAACCAGGTCTAGTTTCCCCGGTTCTGGAACTCCGGATTCAAAAACCATGGATAAAGTGATGAATCATCAACTGGCGGCTTCCTCGGAATCTGCTGAGGAGCAGAAGGGCGCTAATACGTATATGTTTACAGAGACCGGTGAGCGTATAAAGATCGAGCACATGAGGCGGGAGGAGATCATCAACTGCCACTGCGGCTTCCGCGAGGAGGACGGGCTGATGGTTCCAGAAAAGTACACATGCAGTATATGCCTGAACCCGAGGCGCGGGCGCCGCTCCAAGCGCTTCCTTCACGACCAGGACAGATTGTACGAAGGCCTGCTGCCCGGGGCGAAGCCCTGCGAGTCGCTGAGGAGGTCGCACGAATTGTCGGGCAACCTGCTGCGGATACAGGACGCCTTGCATGCTTTGAGAGTCAAGTACTACGTTGCCACTAAAAAGGATCATCCAAAACTGTACCTCTGGGCAAAAGACTGGGAGAACGCTGAAGTGAATTTCACTCAAGAAAGACTGAACTCTGACTATTCCGACTTGAATATAATAATCAATAACATTGGCAAAGAGAACCTACCTGTCAAACACGAAGACGTACATTTGGACTTGCGGCCGCCTTTGACTGATGATTTGGACCACGATAGGTTTAGTCAAAGGGACTCATCCAACTCCTTGCTAAATCTTACGGCAGCTCTGGCCAGTCCTGGTGGTACTTTGGATCTGCCTATTACTACATCTGAATTGGAGAGATTAGCTAAGTCTGTGCAAGAGCAAGAAGTGCGTAACGTATCAGCCCCGCAGCCCGAAGCGGCCATCGAGAACGGCGCGTGTCGCGAGCGCCTGCTGCGCCACGTGCAACGAAGCCAGGCGCTCATCGACGCCAGGCTCGACTCTATAGAGGCACAAGTCGCTGAGTTAGAGTCTCAAGATCCATCTTTCGAAGACGACGAGACTGCAGACTATTTCCCGCGCACCAAGCAAACTATACAGATGCTCATGCACGACCTTGATACTATGGAGGAGCTGGGAATTATAACATAA
Protein Sequence
MAVKKCSIANCSSTLSSPEDIGVTYHKYPKDTGIRENWLSATRQTYDNIDNSTYVCSRHFCKSDFKVYQDSKYVLKSDAVPSIFSWNPNIKSNKMDPESITEANSEEQTHNTSSSSKESEEENVDAIQKCIDEQEIEIQNKRNQDETQEKAEMDNKQKSENPETPESTEKQENVENLVIEQVENVVLCTKMMDMILSVSEDKADSKKEVKPIAKQSVSPKGNNSIALSVGSKVVAKDFEELWYPAEIVEVDHDEMEVLVHYENVSNKPDEWINISSPRLRPINKPSTPIETPALTPAVTEVAPPEEQAAPAELVQEIKVEDKPKLHFVVGERCLARWRDNRRFIATIANDLSNGVYEVIFDDGFHWKCNTSRLYKLKDPGKHSECLSVDTSMPPKPSTPSPVQAGAGPSTASPLNALTPTPIFHTHLFDPTRDYLGPKSERREMKRKLNIKEIFNIGQKKKKKETPPKEKVARVVKEKKPRVLLRKXXXXXXXXXXXXXXXXXXXXXXXXXPDAVASIIGTVAKEDAAKPTVPEIKTEPDTEKSLDSSEVKEEIKLEQSEVQEGSDKITLDDLVDNSSVASTEIDIPFDLDLPQSTQDMELDLEEELKLENFEKPDESKKEDIEKMKEVISKLEVGLIKIEDDHQNRIDSPKPEPQPALKPELKPELKSESTPEPEIEVIEVNPAAGEVDKIDKVEPQEKSKRKLSKIKKSKKLRLLQEKKVKKQVEKVKSELEEMKRQVEEMRKQMLLKTEQPSPAPRPSEMPESFLLPGEWCCKWRDGQPVGAVSEIEGDSKMDANNKMALPRRSVQVEDKRLPEGWSKHMVRRRLGQSAGKWDVVLVSPTNHRFHTKNDMRNYLELNRNEELKPYEYALLDFGVHLKLSRRMGWYTTTVDGSSDAVVNTPVNTMSPLAKAKKYRVYRKDDRKEKKKKRKKQIAAFRRQNASLVTTAGTSGQASIGSTEFEATPMEYPALEDGYVYVGSLKVQILENLLRCPAEGCFKNFRNNTLLQMHIKHYHRELRKMLGATPKVLDLAQQRTLPTEPEPVRQLDSRILKIKITRPPKRAEEPKPELKVFSSEINVNVEAATPTKTDLPIPRSQDSPKLREALANKPVKRPKVLLPVRRPDPEPIPDEFEEESPALTYDDDTMESTIEVMEPQDFETAISTHTVTKPIDAFGKKAEKKRKCFSTVPRRPASEEDEWFGMNSDVETRSSFPGSGTPDSKTMDKVMNHQLAASSESAEEQKGANTYMFTETGERIKIEHMRREEIINCHCGFREEDGLMVPEKYTCSICLNPRRGRRSKRFLHDQDRLYEGLLPGAKPCESLRRSHELSGNLLRIQDALHALRVKYYVATKKDHPKLYLWAKDWENAEVNFTQERLNSDYSDLNIIINNIGKENLPVKHEDVHLDLRPPLTDDLDHDRFSQRDSSNSLLNLTAALASPGGTLDLPITTSELERLAKSVQEQEVRNVSAPQPEAAIENGACRERLLRHVQRSQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTIQMLMHDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00953530;
90% Identity
iTF_00954562;
80% Identity
iTF_00954562;