Basic Information

Gene Symbol
Zfa
Assembly
GCA_905163435.1
Location
LR991013.1:2030826-2048804[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.00079 0.066 14.4 3.2 1 23 257 279 257 280 0.96
2 11 0.0002 0.017 16.3 0.4 1 23 286 308 286 308 0.98
3 11 1.6 1.3e+02 4.0 2.1 1 11 312 322 312 335 0.70
4 11 4.8e-06 0.0004 21.4 1.5 2 23 341 363 340 363 0.94
5 11 9.8e-05 0.0082 17.3 0.3 2 23 370 392 369 392 0.96
6 11 1.2e-05 0.00099 20.2 0.2 1 23 405 427 405 427 0.97
7 11 1.9e-05 0.0016 19.5 0.4 1 22 433 454 433 458 0.94
8 11 0.00027 0.023 15.9 1.1 2 23 467 489 466 489 0.95
9 11 2.2e-05 0.0018 19.3 0.4 1 23 495 518 495 518 0.96
10 11 4.2e-06 0.00035 21.6 0.2 1 23 527 549 527 549 0.98
11 11 0.028 2.4 9.5 0.2 1 19 555 573 555 578 0.87

Sequence Information

Coding Sequence
ATGGATCAAAGTACTACTCTGAACCACAGGGACGTGGACGAAAAAGCCGAATCAGAAAAGAAGTATTGTTTTGCCTGTTTGTGTGTAAATGAAGAGAAGAATGTACAAAATTATGCATTTAAATGCGGCCCCCTTAAGAATATATTCCAGATGGACTGCATATTTCTGTGTTATCTATGTAAGAGGACGGCCCAACACACTGAACAGTTCATACAGAATGTCCAAAGTAATCAAATACTATTGGAAAACTTTCAGAAtGTAATGGATGAAACATTGAAATCTGTACGGGCACAGAGGCAACCACTAGTCAACCTAAAACAAGTGCCATTTGATGTGATAGAGCTATCAGAGCGAGACGGCCATAGTTCCGAGGAGACCTGCTCTGTCGTGTGCTCTCGGAGTACGAGGAAGGATGTCCAGGTTAAAACGGAGATGAAGGAAGAGGAGTATTTGGATCATCTAGAAGGAGAGTTTATTAACGGTGatgAGTTCTCCGAGTCATACGTAAAAGATGAAGACGACACATTTCCCCTGAAAGCCTTGCTGAAAGAAGAATTAGAACTTGAAGACCTTGACAGCCTAGACCTTATGAGTCTTAGTGCAACGTTGAAGAAGAacaaaaacaagaagaaaagtaaaataaaacgggAAGCCTCCGCACAGATAGAGAGAGAACGACCTAAAATAAAGACGATATACATAACTCGGGAACAATGCATGGAAGAGCGCGCTCTAATAGAACAGGATCCGAAATATTTGAACTTTCCGTACACCTGCGAGAACTGTCTCAAGGGGTTCAGTTTTAAAGGCAGCTACGATAGGCATATGGAGAAACATCATCAGTGCATGGGTGACTACGAATGTGATATTTGTAAGCAGAGACTGGATACAGAAGATAAACTAGTTAACCATATGAGGTATCATTTAATTCGCTACAAATGTCCTGAATGTGGCCTAACAAGAAAGTGTCGCATGACGATTAAAGATCATTACAACGCGTATCACAGCCAAGGTTTTCAGACGTGTCCGTTTTGCAGCAAGACTTTCAAACGCCAGGTATCACTACGCAAACATATAAGCTACGTACACAGGCGCAAAGGACGCGTACAATGCGCGTACTGCCAAAGGACATACGCGGATAAAAGCGTACTACGCTCGCACATGATCATGAAACATTCCAAAGAAGTGTCAGCCCTCCCCATAAGCAAGAAGTACGTGTGCCAGGAGTGCGGCATGGCCTTCAAGGCGCCTTCTCAACTGAAGAAACACAGCATCAAGCACTCTGAAATACGGGAATTCTACTGTGTTGAGTGTGATAAGAGTTTCAAAACAGATGCTACATTGAAAAACCATTTGAAGACTGCTGCAATCCACGTCAGTTATTTACAATTACCGTTGCCTTGTCTTCACTGTGACAAGCGTTTCGCGATACGTCGAGATCTAGAGAGACACACCAACAGAGTACACCTCAATATCAGGCCGTTTATTTGTGATAGATGTAATAagTCGTACGTGAACAATTGGTCGCTGAGGGAGCATCAGCGGCTGGCGCACGAGGGGTACAAGCGACCGCTGCAGTTCCCGTGCCCCATGTGCGACAAAGTGTTTGATCGCAACCAGATCCTAAAAGTGCACATCCGCACCCACACTGGAGAGCGTCCGTACGAATGCAGCAAATGTCCAGCTTCATTCAGCCAGGCCAACATACTCCGCACCCACGACAGACTTATACACCTCAAACAGACTAGAGACGGACGGCCTAGGGTCAAATAG
Protein Sequence
MDQSTTLNHRDVDEKAESEKKYCFACLCVNEEKNVQNYAFKCGPLKNIFQMDCIFLCYLCKRTAQHTEQFIQNVQSNQILLENFQNVMDETLKSVRAQRQPLVNLKQVPFDVIELSERDGHSSEETCSVVCSRSTRKDVQVKTEMKEEEYLDHLEGEFINGDEFSESYVKDEDDTFPLKALLKEELELEDLDSLDLMSLSATLKKNKNKKKSKIKREASAQIERERPKIKTIYITREQCMEERALIEQDPKYLNFPYTCENCLKGFSFKGSYDRHMEKHHQCMGDYECDICKQRLDTEDKLVNHMRYHLIRYKCPECGLTRKCRMTIKDHYNAYHSQGFQTCPFCSKTFKRQVSLRKHISYVHRRKGRVQCAYCQRTYADKSVLRSHMIMKHSKEVSALPISKKYVCQECGMAFKAPSQLKKHSIKHSEIREFYCVECDKSFKTDATLKNHLKTAAIHVSYLQLPLPCLHCDKRFAIRRDLERHTNRVHLNIRPFICDRCNKSYVNNWSLREHQRLAHEGYKRPLQFPCPMCDKVFDRNQILKVHIRTHTGERPYECSKCPASFSQANILRTHDRLIHLKQTRDGRPRVK*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01093377;
90% Identity
-
80% Identity
-