Basic Information

Gene Symbol
Znf423
Assembly
GCA_963924605.1
Location
OZ004605.1:14476235-14483639[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 2.9e-06 0.0002 22.1 0.5 1 23 84 106 84 106 0.97
2 22 0.072 5 8.2 3.3 3 23 114 134 112 134 0.97
3 22 5.7e-05 0.004 18.0 5.3 1 23 140 162 140 162 0.98
4 22 0.00033 0.023 15.6 0.3 1 23 168 190 168 190 0.98
5 22 0.0016 0.11 13.4 1.2 2 23 203 225 202 225 0.96
6 22 1.2 84 4.4 0.5 2 23 248 270 247 270 0.94
7 22 0.54 38 5.5 0.3 1 20 307 326 307 327 0.93
8 22 0.0093 0.65 11.0 0.0 1 23 417 439 417 439 0.97
9 22 0.00017 0.012 16.5 0.0 2 23 454 475 454 475 0.94
10 22 4.5 3.1e+02 2.6 2.2 3 23 485 507 483 507 0.75
11 22 0.42 29 5.8 2.7 1 23 512 535 512 535 0.96
12 22 0.096 6.7 7.8 1.8 2 23 600 622 599 622 0.95
13 22 0.46 32 5.7 0.5 3 23 675 696 673 697 0.91
14 22 0.0017 0.12 13.3 4.6 2 23 708 729 707 729 0.97
15 22 0.0012 0.085 13.8 0.3 1 23 738 760 738 760 0.97
16 22 0.012 0.84 10.7 1.7 2 23 768 789 768 789 0.96
17 22 0.31 22 6.2 0.1 1 13 835 847 835 850 0.87
18 22 0.015 1 10.4 0.5 1 23 898 920 898 920 0.95
19 22 0.063 4.4 8.4 0.5 2 23 929 950 929 950 0.95
20 22 0.0011 0.076 14.0 0.3 1 23 958 980 958 980 0.97
21 22 0.46 32 5.7 1.8 1 23 987 1009 987 1009 0.94
22 22 0.12 8.5 7.5 0.2 2 21 1039 1057 1038 1058 0.93

Sequence Information

Coding Sequence
ATGCTGTTTAAAGGTAACAGTAGTCGCTTAGAGTTGCTAATCGAAAAAATTCATAACCATAAAGAAAATTCTGAAATGGCAGATATCGTTTCAACaggttCCATTGGTACAGAACATGAAAGTTGGGAATCGAATACGCCAGAACAAGCTTCACCAGCACCAAGTTCTTGTCCGACACCAAGTTCCAGTTTAAGTGATGTTGCCGAAACGGATTTAGCATTTACTGTAGGAATAACAGAAACAACCCCATACGCTTGTAAAATATGCAATAAGGCTTTTGCTAGATCTTCTTTATTAAGTAAACACGAACAAtctCACACTGATCAACTTCAATATGGATGCTCTTACTGTCCTCGACTCTTCAAACATAAAAGATCTCGCGATAGACATATTAAATTACATACTGGagataaaaaatacaaatgtatacACTGTCAAACGGCATTTTCAAGAAGTGACCATCTAAAAATCCATATGAAAACTCACGATAATAGCAAACCGTTTCGTTGCTTACTATGTAATCGAGGGTACAACACAGCTGCAGCTTTAACATCCCACCAGCAGAGTCACTCGAAGCAAAATTTGGAAGAAAATCCGCAAAACTTAAAATGCTTGCAATGTCCAGAAGTTTTCAATGGGTGCGATCAACTTCAAAAACACGTTTCGACATTCCACAACAACATTCTGCTAAACTCGTCGCCATCTAAACAAGCCCACTCTCCGATAGAATTAACAAAATGGGTTTGCATGTATTGCAGCAAAGATTTCCTAATGATAGAAGAAATGCAACACCACATAAACACCGACCACAGCGCTCTTGTAAACGGAAATTTTTTAGTTAGCGGAAAAAACCTTTTAGAACCATCCAATAATAAAGACCCATCAATAAACGACCAACAAACTGATGGAACACCAACGTACGCTTGTGATAGTTGCACTATGCACTTTGACTCGGTTGACAAGTTACGAGTTCACGAAAACTGCATCCATTGGAAGCCTCCTCAGCCATTAGTAACTCCATCAAAACCATTTATAAAAGACTGTAACACTTGTTTAATCCCTTCTCAAAATTCAGAAACACCCAACAATTCAATATCCGTACAACCTATTCAACTGCAGCCGACCGATTTGAGTCGTAAAAGAAAAAGTGGAGAAGATGAAAAAGCTTCACCTAAACGAAATAACACTTCAGTTTCGAGCGTTGCTAGTGCTTCGTGTGAGTCGCCAAAAAAAGAAGAATGGACCAGTTATATTTGTAGTATATGTGGTACACAGTTACCAAATTTTGCTTCCTTTATGGTACACATGGATATTCATATGTCGGTCAATGCGACTCCCACCAATGTTATACTAGGAGGATATTGCCCACTATGTGGAGAGGCTTATAGGGATcaaactgaattaaataatCACATCGTTTTACACACTTTAACCTACAAGCCTGGATGGTGCTGTAGAGTTTGTAAGAAGTTTTTTAACGACAATTTAGAAGACTTTCAAAGACACCTAATGGAAAATCACGCTTGTACCACCTACAAGTGTTGTGTTTGCGAACaactctttgaaaataaaacagCTATGTTGatgCATTTAACCAAGAAGCACAGCAACGAGTGTCAGCACTATCGATGTAAATTTTGTCCAGAACAAATTTTTCACAATCAGTTGAGTGCAGAAATGCATATATCACAACACGTCCCACGTTTGTTTAACCCAACACGTAAGTCATCTACTTTTGGATCGTACTCTTTCCCAAACGATTTTAGTGCAAGATTAGGTTCgacaataaaaaatttgcaatgTCCGTTTTGTCGCCAGTGTTTCAAAGGagaatatttacaacaaatgcATATTTTGAAAGACCACAAGGATTATTTAGAGGCCCACGGCTCGCGTGTTGCGGATGATTGTTCTTTGGAGCAAATATCTTTGAGAGGTCAAAGGGAGGTTCAAGCAACTTCACCGACGGTTCCATACGCAAATTCCTTACCATACGATAAAACTTTAATCGAAAATGTTATTTGCGACATTTGCGGTTCGTCCGATTTTAGTAGTAGCGCCGAATTGAGTTCACATAAGAAGTTGCATCACGTCAAGACTAAAATAGGACCGGTGAGTTTGCAGTGCGCTTATTGCAACGAGCACTGCAAGTCTCGTACAGATTTAGAAAATCATATGAAAAATCATCAAATTAATAGTAGTAAAGGTAAACATAAGTGTAATATTTGTGATGAAATTTATTCGTCCGCAATAACTTTAGCCGAACATAAATTATCGCACTGTAAAATCGTTTCGGGCAACACTTGCACTCAATGCAAGACGGTCTTTTCGGACGAACAGACCTTTTATTCTCATCAATTGCAACATAGTACGGTTTTAAACAAATCAAACTCGCAAATTTCGCTACCAGCGAACTGTATAATTTGTTGCCAAACCTTGCAAACTGACGTCGAAATAAAGCTCCACGCCAATTTCCACCTCCAGCACATAATCCAAAAGGAATATTTGTGCAACATTTGCAACAGGGTTTTCGACACTCGCACAGGAATAATAATTCAAGGTTTTGAGAAAAGTTgcgaaaatttacaaatatccGTATGTAAAGATTGTATAAATAAGTGCGGAAGCAACAGTAGTTCCAACAGTCCAAGACTTCCAAATATAAAAAGCGAAAttgtagataaaaaaatttattcgtgCATCAAGTGTCCTCAAACGTTCGAGAACGAGAGCGACGTTAAAAAACATTCCATAACCCACATATCCAACGAGGGCTCAAACAACGAGTGTCACATTTGTAGAAGCATCTTTTCGACACCCCTTAAACTCCAATTACACGTAATAGAGCATAGTTTTTTCGGAACGGGCCAATTTAGATGTTACATTTGTAGTTCAGTTTTTACAACAGCCAACGGTTTGCTCTCTCACATGTTAGAACATGGAACCAACTCCAAACCTTACGAATGCGTTACTTgccaaatgaaattttttttccaaacagAATTAGATAATCACAAATACGAACATATATTATCCCAAGCAGTTGCTCaatctattaatttaaataatttagacgAATCCGATTCGGTCGATATTTTAAGGAAAGATTTAACTAAATGTCCATACTGTGATACGTCGACGTCGCTAACTTATTTAAATGTTCATGTACGATTTTGCTCACAAAATCccgattttaagaaaaaaaatgatgcCAAACAAAGGAATCAATTTCTAGAAAATTCCACAACACAAATTGAAGATAAAAGTACATCAATTTCATAA
Protein Sequence
MLFKGNSSRLELLIEKIHNHKENSEMADIVSTGSIGTEHESWESNTPEQASPAPSSCPTPSSSLSDVAETDLAFTVGITETTPYACKICNKAFARSSLLSKHEQSHTDQLQYGCSYCPRLFKHKRSRDRHIKLHTGDKKYKCIHCQTAFSRSDHLKIHMKTHDNSKPFRCLLCNRGYNTAAALTSHQQSHSKQNLEENPQNLKCLQCPEVFNGCDQLQKHVSTFHNNILLNSSPSKQAHSPIELTKWVCMYCSKDFLMIEEMQHHINTDHSALVNGNFLVSGKNLLEPSNNKDPSINDQQTDGTPTYACDSCTMHFDSVDKLRVHENCIHWKPPQPLVTPSKPFIKDCNTCLIPSQNSETPNNSISVQPIQLQPTDLSRKRKSGEDEKASPKRNNTSVSSVASASCESPKKEEWTSYICSICGTQLPNFASFMVHMDIHMSVNATPTNVILGGYCPLCGEAYRDQTELNNHIVLHTLTYKPGWCCRVCKKFFNDNLEDFQRHLMENHACTTYKCCVCEQLFENKTAMLMHLTKKHSNECQHYRCKFCPEQIFHNQLSAEMHISQHVPRLFNPTRKSSTFGSYSFPNDFSARLGSTIKNLQCPFCRQCFKGEYLQQMHILKDHKDYLEAHGSRVADDCSLEQISLRGQREVQATSPTVPYANSLPYDKTLIENVICDICGSSDFSSSAELSSHKKLHHVKTKIGPVSLQCAYCNEHCKSRTDLENHMKNHQINSSKGKHKCNICDEIYSSAITLAEHKLSHCKIVSGNTCTQCKTVFSDEQTFYSHQLQHSTVLNKSNSQISLPANCIICCQTLQTDVEIKLHANFHLQHIIQKEYLCNICNRVFDTRTGIIIQGFEKSCENLQISVCKDCINKCGSNSSSNSPRLPNIKSEIVDKKIYSCIKCPQTFENESDVKKHSITHISNEGSNNECHICRSIFSTPLKLQLHVIEHSFFGTGQFRCYICSSVFTTANGLLSHMLEHGTNSKPYECVTCQMKFFFQTELDNHKYEHILSQAVAQSINLNNLDESDSVDILRKDLTKCPYCDTSTSLTYLNVHVRFCSQNPDFKKKNDAKQRNQFLENSTTQIEDKSTSIS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00950128;
90% Identity
-
80% Identity
-