Mser003482.1
Basic Information
- Insect
- Malthinus seriepunctatus
- Gene Symbol
- FOXL2
- Assembly
- GCA_963924605.1
- Location
- OZ004600.1:51501614-51503082[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 6.8e-41 7.8e-38 128.9 0.1 2 88 80 165 79 165 0.97
Sequence Information
- Coding Sequence
- ATGAAATCGAAAGTTAAATTCGGCAACTtcaatacaataattaataatgtattATTGTATCTGGATTGTCGTTTAGCAATACAATGCCGCATGCCTATAGCAAGTGCTTCTTCATCAGGATACAGCTCTCTTAGCTCTTCTCAAACTCAATTAGCTGAATCTACCGATAAATCTCGTGCCCCGAGTTCTAGGCAATCACCGCAACCGTCTTCAAGTAGTAATAATAACAGTCAAACGAAACCACCTTACTCATACGTTGCACTTATAACGATGGCAATTGAAGATTCTCATCATAAACGAGCAACTCTTTCAGAAATATACGCATACATCACTGCAAAATTTCCTTATTTCGAGCGTAACAAAAAAGGATGGCAAAATTCTATCCGACATAATCTTTCGTTAAACGAATGTTTCGTTAAAGTGCCACGAGAAGGTGGCGGCGAACGTAAGGGCAATTATTGGACGTTGGATCCTCAAAGTCACGACATGTTCGAAAATGGAAATTACAGAAGACGCAGAAGAATGAAACGTCCATATCGTTCGACGCAACCTTATCCGAAAGCTTTCTTCGGAGATTCTTTAGGTCAACACGGATTGCCGTTAACTCGTAACATTTTTACACCTCCGACTTATCCACCGACTTATTCTCGTTACGATACGGCTTCGTGGTTGAGTCAATCACAAATTGCGTATTCGAATTGTGGAACTCCGACGGCATATTCTCAACAAGGTTATCCTTCTGCCGCATTTAGCGCTTGCGGTGTCCGTCAAGATACTTCTAGATTTCCACCATATTGGCCACCCGATAGTGAGTACCACCCCGGTCCCCACAACTCGCCTCCCGCTGATCCCCAGCTACTTTTACAGTGGTGA
- Protein Sequence
- MKSKVKFGNFNTIINNVLLYLDCRLAIQCRMPIASASSSGYSSLSSSQTQLAESTDKSRAPSSRQSPQPSSSSNNNSQTKPPYSYVALITMAIEDSHHKRATLSEIYAYITAKFPYFERNKKGWQNSIRHNLSLNECFVKVPREGGGERKGNYWTLDPQSHDMFENGNYRRRRRMKRPYRSTQPYPKAFFGDSLGQHGLPLTRNIFTPPTYPPTYSRYDTASWLSQSQIAYSNCGTPTAYSQQGYPSAAFSACGVRQDTSRFPPYWPPDSEYHPGPHNSPPADPQLLLQW
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00949603; iTF_00267937; iTF_00270854; iTF_00927309; iTF_01291282; iTF_00269557; iTF_01293382; iTF_00788328; iTF_00977127; iTF_00838219; iTF_00398644; iTF_01345498; iTF_00853756; iTF_00641203; iTF_01515294; iTF_01284063; iTF_00152064; iTF_00001770;
- 90% Identity
- iTF_00949603;
- 80% Identity
- -