Basic Information

Insect: Malthinus flaveolus
Gene Symbol: MBD-R2_1
Assembly: GCA_950108345.1
Location: OX467285.1:14325496-14331479[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 9.9e-19 3.4e-15 55.6 0.1 7 73 411 478 405 482 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	9.9e-19	3.4e-15	55.6	0.1	7	73	411	478	405	482	0.86

Sequence Information

Coding Sequence: ATGGGTCGCAAGTGTGCAGTTCCGGGATGTTTATCAGAAGAGGGAAGAGTTGAAGATCGAGGGGTGACATTTCACAAAATCCCCTTACATTCAGATATACGGCCAAAATGGATGTCTTTGTGTCACGTTCCTGAAGACAAACAGGTAGTGAAAGTTGTGCACGTATGCTCTAGACATTTTTTGAAAGCCAATTTTTGCCGTTTCAAAGGTAAAAAGTATATGTTGAGGCAGGGAGTGCTTCCCAGCGTTTTTCCGTGGACAGTAGTGAAGAAAGAGCTACTAGACGATACTGATACGAAAACTGATCCATCTTTACAATCCGAAATCAAACTAGCTGGAGAAGCAGGAGATAACGAAAAGGAACGGGATGCTACAGATTATGAAATTAAGTCGGAGCATATGGATTTTGGTGCCGAAGAAACTATCGGTATAAAAGAAGAAGGTGGTGTTAGTAACGAAGCATTAGTTAATGTGACTAGTGAAGATACAGATTTAGGATCAACTCCCAAACCATCGAAAGTTATGGAAAAGTCATCGACAACTATCGAACAAAAGGGCAAAGCGCTTCAAACTTCTTCGGgcgttttaaacttttttccaaaCGCTCGTCTCGAAGCCCTCGATTTTAATGGAGCCTGGTTTACTGCTAGAATTGTCGAGATCGACTACGAAGATAATGAAGTTTTAATACACTTTGATAAATACTCTAGTAAATATGACGAATGGATTAGTATGGATAGCTGTCGTTTACGCCCGTTACAAACAGTAAAGAAACAGATAAATGAAGGTTTTATAGTTGGTGAAAAGTGTTTAGCATCGTGGAGCGATGCAAGAAAGTTTCCTGCTACCGTTACTAAAGTTATCGACAAAGagACTTATGAAGTTATTTTTAACGATGGTTTTGTGAAAGTGCTGAAAGCTCATAGAATGGCTAAAGCAGATAGTAAATTAATTGGTTCGGCTCCATTGTTTGAGCCGGTAGAAGGTACCAAACAAGATCGCCGtgataagaaaagaaaattgaatgttgcTAAGCTCTTTCATAAACGGATAAGACACGATCTCGACGATAGTTTTTCTAGCGTACCAAGCACGAGTGCCGTTCAAGAACGCATGACAAGTCCAGTTAGTGATTCGGACGCTACCACACCAAGATGGGAAAATGGTCGTCCGATAGGAGTTCAGTCAGTTATTGACACAAGTGATGGTGCAAAGAAATCAATCATTGTACCTGATTCTCGTCTACCACCAAATTggcaaaaacatttattacagAGAATTTCTGGCGTGTCTGCAGGAAAATGGgatgttattttaataaatCCTGATGGTCGCAAGTTTAGAACTCGTTCTGAGATAAAAACTTACTTGGAAGAAAATTCCCAACTCAATTATAATGAAGCAATGTTCGATTTTAGTTTACATAAAAGACAGAGACAAGCTAGACGTTCATTGCAGCCAGCCGAGCCATCGCCGATTTCTGTAAATCCTGAGCCACCACCCATAGAACTGGAAGAAGTAAATTtcaacagtttaaaaattttattagtcgACGATGCGTACAAATGTCCAATAGAAGGTTGTGGTAAAAATTTCAGACGCGAAAATTTGGCGCAAATGCACGTCAAACATTATCATCCAGAATACACCAAATTTCTCGACTCAACTCCGAATGTTGCCGATTTAGCATACGCTAGAACTGTAGGCGAATCTTTAGATAAATCACCGGATAgaaacgtcaaaaatttttctgtaaaacaaACTCCTAGAGTGTCTACACCAAAAGTATCGACACCCAAATCTGTTGTTCCACCGTCGATTGTCGAGCccgataataattatagtcAGCACCAACAAGAAACGATTAATGCCCAGCAAGCCTCACAGTTGCAAAGAACAAAAGATTccgaaatattaaaattgttaaacagTAAACCGACGGAGGACAGTGGCTTGCCTAAATATCCGCCCGGTTTACCCACAAATATGTATCCCGATATTAAGTTGAAAGATTTATTGAACAGGTCCGAAGGAATACCAAAACGTGAAGatataaatcttaaaaatttaagcacTACTAGACCTAGCGGAATTAAAACGCTGTTACCAGTGATTAGAACGACCGAAGTGAAAAAAGAAGtagaaatggaaaaattaccaatttttgacggcccaaaagttccaaaatcggctatgAAACGTAAACGGCCATTTTCGGAGAGTATCGACATATTTAAACCTCCCGAAATTCTAGAAATGCCAGTTATGACAGAGGCTCTTGTTAAGCCCGAACCGGTGAACACCGGTTACATCGTCGAAGGGGGAGAAGTTatcaaaattgttcaaatgaAAAGcgaagaaattataaattgtactTGCGGAATTACGGAAGAAGACGGACTCATGATTCAATGTGAAGTTTGTTTATGTTGGCAACATGCTTATTGTAATAACATTCAAAGAGAAAATCAAGTTCCCGATAATTACACTTGTTACATATGTCAAAACCCAATGAGACAAAGGTCATCTAAGAAATACTTTCACGATCAAGATTGGTTAAAGAATGGCACCTTACCTGTTGCGAGTTATCAGTGTAAAGACGATGCGGTCTTAAAGGAAAggtttaacaaattaaaaatgtcgcACGATTTAAGTGGCAGGCTGTACGAGTTGAAGGATTTCATGCACTCGCTTAAagtcaaaatgaaaattgccGAcaataaaaatcatccaaaattatatttatggtCGAAGCCGTGGGAAAAGCCACCTCTACCAGAAAAGACAAACCtgaaagaagaagaaaatttggaCGTAAAGTCAAGCTTTACGTTTCCCAATCAGTTTGATAAAAGTGAAATAGATTTGTTAAGCAGCAAAAATGAATCTCAGAACGAATCTGTGTTACTTTCACTTTTGAAGTCTGCAAAAGAAGAACAGAAGATTAAAGAAGAAATCGAATTCGATAATCTTATGGCGAATAATTTAGAACCTTCGCCTTTTTCTACTCCCATAATACCTCAGCCTGAAGCTGCGATCGATTCGGCCGAttgtaagttaaatttattggaTCACATTGCCCACTCGCAAACACTCGTAGAAGAACGTCTTAACGATCTCGAAGAACAAGTCAATTTGTTGgacgaagaaaataataatacgcCAGAAGAAGTTGCAAGAACTTGCCTTACTATGCAGTTGTtgttaaaagatttaaaactgCTCAAAGAGTTTAGCGAAACaacatattaa
Protein Sequence: MGRKCAVPGCLSEEGRVEDRGVTFHKIPLHSDIRPKWMSLCHVPEDKQVVKVVHVCSRHFLKANFCRFKGKKYMLRQGVLPSVFPWTVVKKELLDDTDTKTDPSLQSEIKLAGEAGDNEKERDATDYEIKSEHMDFGAEETIGIKEEGGVSNEALVNVTSEDTDLGSTPKPSKVMEKSSTTIEQKGKALQTSSGVLNFFPNARLEALDFNGAWFTARIVEIDYEDNEVLIHFDKYSSKYDEWISMDSCRLRPLQTVKKQINEGFIVGEKCLASWSDARKFPATVTKVIDKETYEVIFNDGFVKVLKAHRMAKADSKLIGSAPLFEPVEGTKQDRRDKKRKLNVAKLFHKRIRHDLDDSFSSVPSTSAVQERMTSPVSDSDATTPRWENGRPIGVQSVIDTSDGAKKSIIVPDSRLPPNWQKHLLQRISGVSAGKWDVILINPDGRKFRTRSEIKTYLEENSQLNYNEAMFDFSLHKRQRQARRSLQPAEPSPISVNPEPPPIELEEVNFNSLKILLVDDAYKCPIEGCGKNFRRENLAQMHVKHYHPEYTKFLDSTPNVADLAYARTVGESLDKSPDRNVKNFSVKQTPRVSTPKVSTPKSVVPPSIVEPDNNYSQHQQETINAQQASQLQRTKDSEILKLLNSKPTEDSGLPKYPPGLPTNMYPDIKLKDLLNRSEGIPKREDINLKNLSTTRPSGIKTLLPVIRTTEVKKEVEMEKLPIFDGPKVPKSAMKRKRPFSESIDIFKPPEILEMPVMTEALVKPEPVNTGYIVEGGEVIKIVQMKSEEIINCTCGITEEDGLMIQCEVCLCWQHAYCNNIQRENQVPDNYTCYICQNPMRQRSSKKYFHDQDWLKNGTLPVASYQCKDDAVLKERFNKLKMSHDLSGRLYELKDFMHSLKVKMKIADNKNHPKLYLWSKPWEKPPLPEKTNLKEEENLDVKSSFTFPNQFDKSEIDLLSSKNESQNESVLLSLLKSAKEEQKIKEEIEFDNLMANNLEPSPFSTPIIPQPEAAIDSADCKLNLLDHIAHSQTLVEERLNDLEEQVNLLDEENNNTPEEVARTCLTMQLLLKDLKLLKEFSETTY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00949941; iTF_00950863; iTF_00950953;
90% Identity: iTF_00949941;
80% Identity: iTF_00949941;