Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0012 55 8.0 0.1 27 46 12 31 8 38 0.88

2 7 0.0095 4.4e+02 5.1 0.0 26 45 39 58 36 64 0.88

3 7 0.86 4e+04 -1.1 0.0 30 46 68 84 67 91 0.82

4 7 0.0068 3.1e+02 5.6 0.1 27 46 93 112 86 118 0.89

5 7 0.009 4.2e+02 5.2 0.0 26 45 120 139 117 145 0.88

6 7 0.86 4e+04 -1.1 0.0 30 46 149 165 148 172 0.82

7 7 0.00081 37 8.6 0.2 26 45 173 192 158 195 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0012	55	8.0	0.1	27	46	12	31	8	38	0.88
2	7	0.0095	4.4e+02	5.1	0.0	26	45	39	58	36	64	0.88
3	7	0.86	4e+04	-1.1	0.0	30	46	68	84	67	91	0.82
4	7	0.0068	3.1e+02	5.6	0.1	27	46	93	112	86	118	0.89
5	7	0.009	4.2e+02	5.2	0.0	26	45	120	139	117	145	0.88
6	7	0.86	4e+04	-1.1	0.0	30	46	149	165	148	172	0.82
7	7	0.00081	37	8.6	0.2	26	45	173	192	158	195	0.90

Coding Sequence: ATGCAAATCCACAGTGGAATTAAAAAGTACGAGTGTGATGTGTGTCTTAAAACCTTCACCATGTCACGTAATTTGTCACGGCATAAACAAATCCACAAGGGTATTAAAAGGTATAAGTGTGATGTGTGTCTGAAAACCTTCACCCAGTCATCTAATTTGTCACAGCATAAAAAAATCCACAGCGGAATTAAAAAGTATGAGTGTCATAAGACCTTCACCCAGTCATCTAGTTTGTCACAACATATGCAAATCCACAGTGGAATTAAAAAGTACGAGTGTGATGTGTGTCATAAAACCTTCACCATGTCACATAATTTGTCACGGCATAAACAAATCCACAATGGTATTAAAAGGTATAAGTGTGATGTGTGTCTGAAAACCTTCACCCAGTCATCTAATTTGTCACAGCATAAACAAATCCACAGCGGAATTAAAAAGTATGAGTGTCATAAGACCTTCACCCAGTCATCTAGTTTGTCACAACATATGCAAATCCACAGTGGAATTAAAAAGTACGAGTGTGATGTGTGTCATAAAACCTTCACCATGTCACGTAATTTGTCACGGCATAAACAAATCCACAATGGAATTTAA
Protein Sequence: MQIHSGIKKYECDVCLKTFTMSRNLSRHKQIHKGIKRYKCDVCLKTFTQSSNLSQHKKIHSGIKKYECHKTFTQSSSLSQHMQIHSGIKKYECDVCHKTFTMSHNLSRHKQIHNGIKRYKCDVCLKTFTQSSNLSQHKQIHSGIKKYECHKTFTQSSSLSQHMQIHSGIKKYECDVCHKTFTMSRNLSRHKQIHNGI

Sequence clustering based on sequence similarity using MMseqs2