Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0002 22 8.3 0.0 86 137 74 125 46 131 0.67

2 5 6.7e-05 7.2 9.9 0.0 102 142 118 158 101 187 0.49

3 5 0.00024 26 8.1 0.0 87 137 173 223 163 237 0.75

4 5 0.0038 4.1e+02 4.2 0.0 88 126 202 240 196 250 0.76

5 5 0.037 4e+03 0.9 0.0 92 109 248 265 240 268 0.86

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0002	22	8.3	86	137	74	125	46	131	0.67
2	5	6.7e-05	7.2	9.9	102	142	118	158	101	187	0.49
3	5	0.00024	26	8.1	87	137	173	223	163	237	0.75
4	5	0.0038	4.1e+02	4.2	88	126	202	240	196	250	0.76
5	5	0.037	4e+03	0.9	92	109	248	265	240	268	0.86

Coding Sequence: ATGTCTTCTAAGTTTTGCCACTCGAATGACTCAGTGAAGCGCGAGAATACGGCGAAAGACACGAATAGACGTAGTAGAGGACGAAAGAATTTTATTACGTACTTTGCATTTTATTTTGcaattccgcttctctgtaagacaACTACCCACAGCAATGAATATTCCTTTCCACTTATCGCAACTATTACAAAATCTTTAGCACAGTTACTTGTCAAGTATCGCAGCGTCTACACATCTTTATCACAGTTAGCTGACAAGTACCGCAGCTTTTACATATCTTTAGCACAGTTACCTGACAAGTATCGCAGCGTTTACATATCTTTAGCACAGTTACCTGACAAGTACCGCAGCGTTTACATATCTTTAGCACAGTTACCTGACAAGTACCGCAGCGTTTACATATCTTTAGCACAGTTAGCTGACAAGTACCGCAGCGTTTACATATCTTTAGCACAGTTACCTGACAAGTACCGCAGCGTTTACATATCTTTATCACAGTTACCTGACAAGTACCGCAGCTTTTACATATCTTTAGCACAGTTACCTGACAAGTATCGCAGCGTTTACATATCTTTAGCACAGTTACCTGACAAGTACCGCAGCGTTTACATATCTTTAGCACAGTTACCTGACAAGTACCGCAGCGTTTACATATCTTTAGCGCAGTTACCTGTCAAGTATCGCAGCGTTTACATATCTTTATCACAGTTACCTGACAAGTACCGCAGCGTTTACATACCTTTAGCACAGTTTCCTGACAAGTACCGCAGCGTTTACATATCTTTAGCACAGTTACCTGACAAGTAG
Protein Sequence: MSSKFCHSNDSVKRENTAKDTNRRSRGRKNFITYFAFYFAIPLLCKTTTHSNEYSFPLIATITKSLAQLLVKYRSVYTSLSQLADKYRSFYISLAQLPDKYRSVYISLAQLPDKYRSVYISLAQLPDKYRSVYISLAQLADKYRSVYISLAQLPDKYRSVYISLSQLPDKYRSFYISLAQLPDKYRSVYISLAQLPDKYRSVYISLAQLPDKYRSVYISLAQLPVKYRSVYISLSQLPDKYRSVYIPLAQFPDKYRSVYISLAQLPDK

Sequence clustering based on sequence similarity using MMseqs2