Mleu017472.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Macrosoma leucophasiata
Gene Symbol
foxn3
Assembly
GCA_036365455.1
Location
JAWQUS010000020.1:15130101-15159756[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.6e-35 2.2e-32 111.7 0.0 2 85 163 244 162 247 0.95

Sequence Information

Coding Sequence
ATGCAGATGGCGCCAATGCGTGGCGAGCGTGGCGGGTCGCCGGCTAAAGGCGCGCGTGCCTCGCTGCCTCTCCCGCGTCGCCTCATTCGGCAGATCGCGAGGCACGTCGCCTCCAGCGGCCGCTCGCTGCGCCGCCTCGAGGTCTCGGGCCGCGTCATCGACAACTTCGACGATATCGATGACGGCTCCGACGAGTCTGACATGGAAGCGCCGCAACCAGCAGTGGCGTGCGGAGGCAACGCCGGCAACCTGCCACCGGCCGACCACGACGACGATCTCACCAGTCTCAGTTGGTTGCAAGACAGAAATCTACTCAGAGGTATAAACCTCACCAAGAGTGATATGGAAGATTCCAAAGCGATCAGCAGCCAAGTGATTGTAaaaaCTGAACCTTCAGTAACGCCGCCGCCGATCGCCCGCGTGCCCTCCCCCCCGCGCACCCCGTGCAAGGCTCCCCCGTCGCCGCCCGCCATCACCACACACACCAAACCTCCCTACTCGTTCTCTTGCCTCATATTCATGGCCATAGAAGCCGCCCCGGCCCGAGCTTTGCCCGTCAAGGAGATATACGCGTGGATCGTGCGACACTTCCCATACTTCCGTCACGCGCCTCAAGGTTGGAAGAACAGCGTCAGACACAATCTGTCGCTGAACAAGTGCTTCCACAAGGTGGCGGCAGCGCCAGGACTCGGAAAGGGATCACTGTGGACCGTGGATCCACAGCATCGTTCTACATTGTTACAGGCGTTCGGTCGGCAACCCGTGCCGCCCGTGGAGGCCGAGGCGCCCGAGGGGGCCGCCAAGAACGCGCCCGACCCGCAGCTGTTCCCCTACCTGGCGCGGCGCCTGGCCGCCGACACGCGGGCCGAGCCCGGCGCCGACGAGTACCTGGCCGCCGCCACCGTGCTCGCCATGAAGTACGGGCCCGCGGTGCTCGACCAGCTCCCTCCGGCGGCCCATCTGGTGATATCGCGCTGCGCCCGCGACGAGCACTCCTACAGCGGCGGCTGCGAAGAGCGGCGCACGGCCGAGGCGCTCCTCAACCTGGCCGGCGTCCCCTCCGAGCCCGCGCCCAGCTAG
Protein Sequence
MQMAPMRGERGGSPAKGARASLPLPRRLIRQIARHVASSGRSLRRLEVSGRVIDNFDDIDDGSDESDMEAPQPAVACGGNAGNLPPADHDDDLTSLSWLQDRNLLRGINLTKSDMEDSKAISSQVIVKTEPSVTPPPIARVPSPPRTPCKAPPSPPAITTHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFRHAPQGWKNSVRHNLSLNKCFHKVAAAPGLGKGSLWTVDPQHRSTLLQAFGRQPVPPVEAEAPEGAAKNAPDPQLFPYLARRLAADTRAEPGADEYLAAATVLAMKYGPAVLDQLPPAAHLVISRCARDEHSYSGGCEERRTAEALLNLAGVPSEPAPS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00875969; iTF_00875118; iTF_00874269; iTF_01402561; iTF_00957782; iTF_01494881; iTF_01115534; iTF_01495602; iTF_01494139; iTF_00204193; iTF_00922717; iTF_00207682; iTF_01151042; iTF_00819875; iTF_00462191; iTF_00342032; iTF_01429753; iTF_00063397; iTF_00341156; iTF_00947718; iTF_01440806; iTF_00000135; iTF_01010185; iTF_00017162; iTF_00427914; iTF_01134604; iTF_01334573; iTF_00806511; iTF_00428820; iTF_01425780; iTF_01367513; iTF_00818970; iTF_00155131; iTF_00156072; iTF_01245755; iTF_00858365; iTF_01538557; iTF_01141476; iTF_01158532; iTF_01206373; iTF_01205522; iTF_01202291; iTF_01203862; iTF_01204694; iTF_01203064; iTF_00114757; iTF_00878685; iTF_00430439; iTF_00177896; iTF_00647816; iTF_01156104; iTF_01543720; iTF_01545580; iTF_01542776; iTF_01544699; iTF_01546463; iTF_00208649; iTF_00353897; iTF_00352856; iTF_00457065; iTF_00777253; iTF_00779337; iTF_00775083; iTF_00621042; iTF_00780857; iTF_00782461; iTF_00777823; iTF_00708994; iTF_01197539; iTF_00172549; iTF_00418789; iTF_00421169; iTF_00185128; iTF_00457833; iTF_00706761; iTF_01506986; iTF_01332363; iTF_01360427; iTF_00637294; iTF_01166413; iTF_00677358; iTF_00824526; iTF_00896591; iTF_00822704; iTF_01491696; iTF_01501904; iTF_00642161; iTF_00280949; iTF_00441302; iTF_01017558; iTF_01264217; iTF_01018397; iTF_00823742; iTF_00404511; iTF_00869440; iTF_01251564; iTF_00761445; iTF_00840141; iTF_00197196; iTF_00431950; iTF_00674129; iTF_01340968; iTF_00994189; iTF_00027580; iTF_00026664; iTF_01148657; iTF_01145121; iTF_01385521; iTF_01386539; iTF_01388285; iTF_00007827; iTF_00736440; iTF_00204948; iTF_01091514; iTF_00780084; iTF_00781643; iTF_00954228; iTF_00953336; iTF_01560948; iTF_00212245; iTF_00722858; iTF_00247859; iTF_00213237; iTF_00247002; iTF_00159647; iTF_01142230; iTF_01149400; iTF_00710007; iTF_00796343; iTF_01079714; iTF_01078894; iTF_01080549; iTF_01507886; iTF_01506159; iTF_00843319; iTF_00113944; iTF_00113155; iTF_01317097; iTF_00112330; iTF_01316138; iTF_00186961; iTF_00357240; iTF_01564376; iTF_00967865; iTF_01415641; iTF_01083117; iTF_01416590; iTF_00006902; iTF_00276090; iTF_01181722; iTF_01220474; iTF_00468013; iTF_00467273; iTF_00720026; iTF_01337594; iTF_00150301; iTF_00256669; iTF_01222301; iTF_00275067; iTF_01403259; iTF_01138783; iTF_01140761;
90% Identity
iTF_00985815;
80% Identity
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