Malb012648.1
Basic Information
- Insect
- Macrophya alboannulata
- Gene Symbol
- egg
- Assembly
- GCA_949628255.1
- Location
- OX451208.1:7465223-7469889[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 0.58 4.9e+03 -1.9 0.0 3 26 295 318 293 323 0.83 2 2 5.1e-14 4.3e-10 39.9 0.0 5 70 638 697 635 703 0.89
Sequence Information
- Coding Sequence
- ATGGCTGGTGTTCAAGAGATGGAGATAATCGAGCTTGGATCCGACGAGGAACATACCGCtgcaaaaaatagaaaaaacaaagtacCCAAACTTTGTACAAACCACTGCGTTAACTTTAAATGCAAATCCGGGGTAAACATGAAAACAGCACCTTCGTTTGCTTGCGTTTTTTATGGATCAGCTTCTgctaagaaaaagaaacgtcTGATATGCGACGTCTGTTTTGACGTTGCAGTAAGACACCAGGAGGATTTAGTGGAATGCCTAGTTAATCGCAAGCCACTTTTGGCCTGTGAATTTCCAGACCATACAATGGAAGTGGAAATATCAGATAGCGATGATTCAGATCATGAGGAACTAAATGGATCCAAGGAAGAAGATGATTACATTCCTGAGGATGTTCTGCTtgatatagaagaaaaaatggacACCACTTTGTccaagatttttaaaaaatatgatattgaGTATCAAATTGAACAGGCAGGAACGGTTCTTAAGCAACAATGGGATAAAATAGATGAATGCAATGAAGAAATGGACAAAAACCTGACTAAAATGATGTCCGAAATGGACAAACTGCGAAATAGCTTGTACGAGGATTTCAAACCACAGATTAAGATGCTTCCTGAGTTGGATATGGACGTTGGATCTACAGAAACTCCTAACCATCCTCTTGTCGCGACAAAGAAAGTCACTCAGATGCGTATTCCTCCAATCACTCTGCCGGATAATCAACCAGAAATTTTACCACTCGATGGAATTGAGACTCCGTCAGTTGCTGTAGATCTCCCCCCTTCTGGTCCTTTAGTAAAACCTTTACCAGATGTTGCGGATCTCGTTTATGTTATGAAACATCCGTTAAGTCCTTGGGTTAAAGCAAGGATCCAAAGTGTTCAGTCGCGATCTCCACCTCAGTACCGAGTCAAAATACTAACAAGAAAGAGTAATTCTGTACTGAAAACAGTCAGTGGTACACAGCTAGCGCTGGCTACAACTAGTCCAGTCTTGATACCAGTAGGTACTCGAATAGTAGCAGTTTTCAAGGACCTTCATGATTCTGGGTACTACAGTGGAGTCATAGCTGAGCAGCCTAAATCGACAAATAAATACAGATACTTGGTCTTCTTTGATGATGGATATGCTCAGTACGTTGTCCACAAAGATATTTTGATAGTAAACGAATGGTCGGCCCGTGTCTGGGAAGATATACCAAAAGAATCTCGAGAGTTTGTAAAAAAGTACATGGAATCTTACCCGGAAAGACCGATGGTAAAATTGCAGACTGGTCAGGTGGTGAAGACGGAATGGAATGCCAAATGGTGGATTGCAAAGGTGATGCAAATCGATGGGAGTTTGGTGCAGATGTATTTTAACGCGGATGGACGAACCGAGTGGATTTACAGGGGTTCGGCGAGACTAGGACCTCTCTACGACGAGTTGCTAAAAGCCAATGCTAGACAGCAGGGCCATCATGCTTCTCTCAATAACGCCAGCCATCGTTTTCCTGCCGCAATCAACCGTAACAGTGTTCCCTATGTTGAATATACCTCATTCAACGCTGAACCAGATGAGGAGATGCAGCCTGCAGATCAAACCAAGGCACAAAAGGTAATAGAAATACAGACCAGCCTAGGAACTACGTCTATTTCTTCTAGTAATGGGGCTGCGGTACCAGCCCCACCTCAAACACGGGCTGTGGCTAGAAAAAGCACTAGTAAAAAGCCAATTGTTGTTGAAACTAGTAATGTTACTGCTAGTATAAATACAGGGAGTAACACTAAGCCTTCGCACAGTATCGTGTATTTTCAAACACAAAACAAGATTCCAACACGTAAATACGTCCCACATAAATGTGGCTCAAGATGCGTCGAAGGAATATCTTTCACACCTGATAGTCTCAGAGGATATTCTCCGCTTTCAATACCGTTACTTTGTGGCTGGAATCGTCAACTGTGCAAATTTCCGAAAGCGAAAAAGGTGATACTGTATCAAGCCCCATGTGGTATTCGACTTCGAACTATAGAGGAGTTGCATCAGTATTTACGTGTAACTGGTAGTCCCATGTCTGTCGACTTGTTCGATTTTGATTACTGGGTACATTGTCTGGCAGAGTTTGTGCTTGACAAATGTTTCGTCAATATCAAGGATCTTAGCTACGGTGTTGAGAACGTGCTGATACCCTGCGTCAATGAATTAGATCATGCTCTACCAGACACCATTAGATACAGTACCCAAAGGCAGCCGACCGAAGGTGTTAGTCTGAATTTagatgaagaatttttgtgCGGCTGTGATTGCGAAGACGATTGTCAAGATAAGGAGAAATGTGCATGTTGGCAATTGACTATACAAGGAGCTACTTTGGGTGGTCGAGTACCGGACAACGCTGTGGGCTATGTTTATAAAAGATTGCCTGAAGCAGTGGCTACCGGTATCTACGAGTGTAATTCGCGATGTAAATGCTCTGTGAAAACCTGTCTGAACCGAGTCGTTCAGCACCCTCTAACTCTGAAACTACAAGTATTTAAAACAGGACCAAGAGGCTGGGGAATTAGGTGTTTAAATGACATTCCGCATGGATCGTTTATTTGCATATATGCAGGCACGCTACTCACggaacagGGTGCTAATGAGGGAGGAAAAAATTACGGAGATGAATATCTCGCTGAATTGGATTACGTTGAGGCGGTAGAAGGAATTAAAGACGGATATGAAAGCGATGTTGTTGATCCAGAGGTGCAAACAGATACGGCCGAAGATGGCAATGAAAAATCAACCGCAGCAAGTGAAGAGGATGAGGATACAGCCAGAGACGAAGGTCTTGATTCTGACGAAGATTTTAACAttggtaaaaatattaatctcAATATGGATCCAGCTTCGTCCATTagAAAACGTTTgagaaatcgaaagaaaagtGAAAGGGAAGGTCGGGGTGGTTCGGAAGAAACTAGCGAAGATGGAAGCACGACTAAGGATTCGGAGAATTCTTCTGTAAAACCTACAGCTGTGACTACTACTCAAGAAGAACAGCGAACAGATTGCGATTTGATAACTATAAGTGACGACGAAGATTACACCAACGTCAGAAGAGAGCCAAGCAGATTTGAACCAAGCGTTAAACCAGCTCAGCTAGGCTCACATCAGTCAAAATCTGTTAGGGAATACTTTGGGGAGGATGAAGCTGTGTATATTATGGATGCTAAGACCACTGGAAACATCGGACGATATCTTAATcaTTCTTGTGACCCGAATGTATTTGTTCAAAATGTGTTTGTGGATACACATGACGTACGGTTTCCTTGGGTAGCATTTTTTGCTCTAAATTACATAAGATCTGGACAAGAACTTACTTGGAATTATAATTACGACGTTGGAAGTATTCCAGGGAAAGTGATTCTCTGCAAATGTGGCAGTTCAAATTGCAGAGGTCGACTTTTATAg
- Protein Sequence
- MAGVQEMEIIELGSDEEHTAAKNRKNKVPKLCTNHCVNFKCKSGVNMKTAPSFACVFYGSASAKKKKRLICDVCFDVAVRHQEDLVECLVNRKPLLACEFPDHTMEVEISDSDDSDHEELNGSKEEDDYIPEDVLLDIEEKMDTTLSKIFKKYDIEYQIEQAGTVLKQQWDKIDECNEEMDKNLTKMMSEMDKLRNSLYEDFKPQIKMLPELDMDVGSTETPNHPLVATKKVTQMRIPPITLPDNQPEILPLDGIETPSVAVDLPPSGPLVKPLPDVADLVYVMKHPLSPWVKARIQSVQSRSPPQYRVKILTRKSNSVLKTVSGTQLALATTSPVLIPVGTRIVAVFKDLHDSGYYSGVIAEQPKSTNKYRYLVFFDDGYAQYVVHKDILIVNEWSARVWEDIPKESREFVKKYMESYPERPMVKLQTGQVVKTEWNAKWWIAKVMQIDGSLVQMYFNADGRTEWIYRGSARLGPLYDELLKANARQQGHHASLNNASHRFPAAINRNSVPYVEYTSFNAEPDEEMQPADQTKAQKVIEIQTSLGTTSISSSNGAAVPAPPQTRAVARKSTSKKPIVVETSNVTASINTGSNTKPSHSIVYFQTQNKIPTRKYVPHKCGSRCVEGISFTPDSLRGYSPLSIPLLCGWNRQLCKFPKAKKVILYQAPCGIRLRTIEELHQYLRVTGSPMSVDLFDFDYWVHCLAEFVLDKCFVNIKDLSYGVENVLIPCVNELDHALPDTIRYSTQRQPTEGVSLNLDEEFLCGCDCEDDCQDKEKCACWQLTIQGATLGGRVPDNAVGYVYKRLPEAVATGIYECNSRCKCSVKTCLNRVVQHPLTLKLQVFKTGPRGWGIRCLNDIPHGSFICIYAGTLLTEQGANEGGKNYGDEYLAELDYVEAVEGIKDGYESDVVDPEVQTDTAEDGNEKSTAASEEDEDTARDEGLDSDEDFNIGKNINLNMDPASSIRKRLRNRKKSEREGRGGSEETSEDGSTTKDSENSSVKPTAVTTTQEEQRTDCDLITISDDEDYTNVRREPSRFEPSVKPAQLGSHQSKSVREYFGEDEAVYIMDAKTTGNIGRYLNHSCDPNVFVQNVFVDTHDVRFPWVAFFALNYIRSGQELTWNYNYDVGSIPGKVILCKCGSSNCRGRLL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01200152;
- 90% Identity
- iTF_01413180;
- 80% Identity
- -