Mrus034272.1
Basic Information
- Insect
- Machimus rusticus
- Gene Symbol
- topi
- Assembly
- GCA_951509405.1
- Location
- OX608053.1:31283903-31287157[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 10 0.58 1.1e+02 4.8 0.4 2 21 169 187 168 188 0.91 2 10 1.4e-05 0.0026 19.3 2.3 1 23 248 270 248 270 0.97 3 10 0.031 5.8 8.8 0.1 2 23 369 390 368 390 0.96 4 10 0.8 1.5e+02 4.3 0.0 1 20 396 415 396 417 0.90 5 10 0.085 16 7.4 1.3 2 22 437 457 436 460 0.89 6 10 6.6e-07 0.00012 23.5 1.9 1 23 512 534 512 534 0.95 7 10 0.00073 0.14 13.9 1.0 1 23 540 565 540 565 0.95 8 10 0.33 61 5.6 1.7 1 23 571 593 571 593 0.88 9 10 3.9e-07 7.4e-05 24.2 0.3 3 23 601 621 599 621 0.98 10 10 0.0056 1 11.1 2.9 3 23 629 650 627 650 0.95
Sequence Information
- Coding Sequence
- ATGGACTACAACGACGAACAATATAATTCAGATATTCTGCTtgcggaaaaaatattttcccaacTCAAAGAGTATAATCCGGGGAAGTGCAATGAAGATGAACAGCAAAATCATACAGCAAATAATGAGGTTTCAAAGGATATACCCTCCGAAGAGAAGGGTCCTTCTTCAGTTTTTAACTCTGGTGTCGAGGATCATTGTGAGATCTCTAACCAACAGTCGTTAGATCAGTGCGAGGCTTCTAGCCAACCTGCTCTAGACCAGTGCGAGATGCCCACTCAGCCCTGCTCCGAAGAGCCGATGGACTTAACTAGCCAGTACGAGGGGCAGATCGCGATGAACGAAATATCCGAGTTGCGGGAGCAAAAAGATTCAGTCGTCGTTATCGACGAGGAGCACACCCAGCGATACTTGGACCTGCTTATTGCTTCGCTGCCTCCCGAATGCTATTCagACGATGTAATTGTTGTGAAGGATTCCATCAAGAACGAAAGATGTTCCATAAAATGCACTAATTGCGAACAGATCTTCAACGAAGAGGCGTTCAACGAGCACATTTGCGACTTTGACGAGAACAAGAATTTCATAAAAGATGAAGAGCCGATAAAATGTTCCACAATTGAATTGGAGGAACCACCGTGCCTTCGTCAACTGCGAGAAAATAACACGCGAATTAGAAAATTTCTGAAGGACGAACTTAAGATAGATATCGGAGGTCCTGCTAAAAGAAGTGATGGGCCCCATGAGTGCAACATGTgcgaaagaaaatttgtgcACGCTTCTGGACTGGTCAGGCACATGGAAAAGCATGCGATGGACCTGATCCCGATCACGACCAACACCACGCAGAGTGGAAGTGGCCTGAAGGTCGTCATCAAGTGTCTCGTTTGTGGAAGGATACTTTTTGGGCATGTCGAAGCCATGGAACACCTGAATGAAAACCACGCACACTTGCTAATCGACGATGAGACCGACAGTGAAAAGGATTTCCCAAGTGAAAGAATTGATGAAGCGAttgagtttattttaaaagagACAGCCGATGAGCAAATAGACAAAACATCAAACCCGTACTTAAAAGTTGTGATCTTGACCTGCACGTTACAGTGCGAATTTTGTGATCTACTTTTCTCAGAAGTCTCAGATCTTTTGCTTCATGCTTCGACCCATGATCCCATGAGGGGATTTGAGTGCTCGTCTTGTGGGATAAACGTTTCAACAGCTAAAGAAATATTCCTCCACTGGCAAGCAGAATGTCCTTACGTGAGAGATGAATTAAAGaagataaataatttgcaGAAGTATCTCGTTTGCAACGTTTGTGAGAATAAATACACTTCCCATGAGCAATTGTACGATCACAGATACACCGAATTTCATTTATTCCCAAGACTGAATAGGAGTATGGGAATTATGCAAGTTTGCTGTGAGTACTGTGGAAGTTTTCACGACAGTGCTAAAGCAATTATGCGACACCACGAAGAGAAACATatgaaaaagattaaaaaggAGGCGACCACGAAATATAGGCAGTATCTTTGCGATGTTTGTGGGAAGTCGTATACTCAATCAAGTCATTTGTGGCAGCATCTGCGTTTCCATagagGGGTTAAGCCATTTGCCTGTAAGGAGCCAGGCTGTAATCGGCGATTTACAATCCGGCCAGATCTTAATGATCACATCCGAAAATGCCACACAGGAGAGCGCCCATATCATTGTCTTGTATGCGGGAAACGTTTCCTCACAGGATCTGTTTTCTATCAACATCGACTGATTCATCGCGGGGAGAGGCGGTACGGTTGTGATGAATGCGGGAAGCGATTCTATCGCGCAGATGCtctaaaaaatcatcaacGAATTCATACCGGTGAAAAACCCTACGGATGCATGTATTGCACGAAATGTTTTAGACAACGTGGAGATCGCGACAAGCACATTCGTGCTCGACATGCTAATTTAGATGCAAATGCGAGATcgtttaatatgaaaaataaggACAATTCGCACAATGGTGTAGTATTTGTTGGAAATGTCGCGTTCCCGACTAGCATGTTTAAGCCGATGATGAGAGATATTGACGAATGCCCAAATATGTActaa
- Protein Sequence
- MDYNDEQYNSDILLAEKIFSQLKEYNPGKCNEDEQQNHTANNEVSKDIPSEEKGPSSVFNSGVEDHCEISNQQSLDQCEASSQPALDQCEMPTQPCSEEPMDLTSQYEGQIAMNEISELREQKDSVVVIDEEHTQRYLDLLIASLPPECYSDDVIVVKDSIKNERCSIKCTNCEQIFNEEAFNEHICDFDENKNFIKDEEPIKCSTIELEEPPCLRQLRENNTRIRKFLKDELKIDIGGPAKRSDGPHECNMCERKFVHASGLVRHMEKHAMDLIPITTNTTQSGSGLKVVIKCLVCGRILFGHVEAMEHLNENHAHLLIDDETDSEKDFPSERIDEAIEFILKETADEQIDKTSNPYLKVVILTCTLQCEFCDLLFSEVSDLLLHASTHDPMRGFECSSCGINVSTAKEIFLHWQAECPYVRDELKKINNLQKYLVCNVCENKYTSHEQLYDHRYTEFHLFPRLNRSMGIMQVCCEYCGSFHDSAKAIMRHHEEKHMKKIKKEATTKYRQYLCDVCGKSYTQSSHLWQHLRFHRGVKPFACKEPGCNRRFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYGCDECGKRFYRADALKNHQRIHTGEKPYGCMYCTKCFRQRGDRDKHIRARHANLDANARSFNMKNKDNSHNGVVFVGNVAFPTSMFKPMMRDIDECPNMY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00718060;
- 90% Identity
- iTF_00718060; iTF_01184079;
- 80% Identity
- -