Mrus022238.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Machimus rusticus
Gene Symbol
-
Assembly
GCA_951509405.1
Location
OX608051.1:41259636-41265585[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7e-14 4.3e-10 40.3 0.1 6 72 212 274 207 277 0.88

Sequence Information

Coding Sequence
ATGGACACGGAAATTACGGAGGAAAGTACATTTTTAGTGGAACAAAAGACGGATACAATTGGTAGTCCGGTGCACAGCGATTATGTCGGCGGGGATGACAGCGACGCCAAAATGACGCTGGCTGTTACCTCGGACGAGGACAGCAGGGAGTCGACCCGAGGACGCAATTGCATCGAGAAGAAGGATCAACTTGGCCAGACGGAAGGCGCAAAAATGCAGGTCCCTCCGAACGATAGCAACGGCACCATAAGGAGGAAATCGAGGGCTAACAGCGCGGAAGGAGCCTCTTCGCTAGATAAGCCCACCACAGCGAAGAGAAAACTTTCTCAGACCGAGTGGCTTAGTGACGACGAAGATTTGTtggggtttgatgaaaaatccGGAGATCCTGTGGaagaaaaacgttttaaaaaaatcaaggaAGACGAAAAAGAGGAAAAGGAACCCGTAAAAGTCGAAGAAGTTGTGAAACTTGTTGAAGAAGAGAAACCCTCTGTCAAAGAGGAAGAACCTGAGACGGAGACTGTAAAGTGCCAGCTGGTTCCAAAAGTTCTGGAGCAGTCTAAGTCTCGTATTGAAGTGGAAAAGGTACACACCCCTTTAAGTAGTAAATCAAAGGTCTCAAAAGACTCCGCATATCGAAAGCCCTTCGACATGGGCTGGAAGCGGGAGTTCGTCTATCGTGCAATACCTGGAGTAAGCAAGGAAAAAGGAGAAGTTTACTACATCAGTCCTGCTGGAAAAAAACTGAGAACTCGAAACGAATTACAGCAGCACATCACACCCGGACTAACGCTGGATAACTTTACATTTTCAAAGGAACCTTTGGGATATGAGGAAGAGGTGATAAGAAGCGCTAAGCCCACCATGAGGTCAAATCCATCAACTCCAACTGATTCGAATCGGGAATCGTTAGGCAAGCGGGTTCCAAAACCAAAAGCGCCAAAAGGAGCAAGTCCACCACCACAAGGATGGACAGCTTCTAAGGCTGTAAAATCAGCAGCATCTCCACGGCCAGTACCAGCGCCTCGTCCACCAGAAGAAAGTGAGCCCAAGAGCACTAGCAAAACAAGTAGCGCAAAAGGCGGAAAATCCGTTAAGAAAGGTGAGCCCTGCACCATTCAGTGCACTCTTGCAATGGGAAAGATACCGCACCTACAATGCGTCAAATGTCTCTGCCTATTTCACCATGAATGCGTCGGACTGGATCGTTCCGAATATGATAGGCACAAAACGAGTAGTGAATCAAAATCGGCTGAGTTCCCTTCAAGTAATCCCTTCCGTCAAGGACGTTACATTTGTGAGCTCTGTGAAAAAGAGCCGAATGCTGCACAAATCTCGCCGACAAAACCTGTCGCACAAAGTCCGActaaaattcaatcaaatttgGCGACTGTTTCTACTAATAATGCTGGTACAGGAGCTGCATCTGGTGCAACGACTGTTGCTTCTGTTACACCTCCTGTGCAGCAGCAGAATCCAGCGACGCCAGGCAACACGCAGCGCAAGGTATCTGAGGCAGGGCCGCCTCCTAAGGAGTTGAAGCAGGCTTCTTCGACTCCGAAGGCTGCTGTACCCCCCACTAAACCCTCGGCCTCTCAAAGTAATAGTAATGAGGCCAACATTGAGCTCAGTGCGGGTTTGCCACAGTCGATTGCTGTGATTAAGGGCCGCAAATACGTTGTTATACGGAAGCCCTGCGTTCCACACTATACTCGGACTGATGATGAGTCTCACAGCAGGAGGAATGAGAATTCCACAGTAGAATCCAGCACAGCACCATCGTTGCAAACAGGCGACGATCTCCCGATGAGAAAACGTATCCCAAACACTCGGAACAAATTTTCTCCAGACTCCCCTGCTGCCCACCAGCCACAACAGCAGCATCTTGTCCCCGCCTCATCAACATCATTGCGACCATCATCAGAAAGTTTCGCTGCAAATTTCTTCAGCAACGTTTCCCTCGGCTACGAGATCctctttcagatttttcagtatttaaAAGTTCAGGAACTTTTACGTGCTGCCTGCGTTTGTAGAGTGTGGTACGTTGTCGCTAATAACAGATCCCTTTGGAAAACAGTCCGCATGAAAAATTCACAGGTAAATGACTGGACAGGCCTAGCAGCCGCCCTACGGCGCAATGAAACCCAACATTTAGACTTAAGAAAGATGCTCACCTGTAGCACAAATGCCGACGAAATGTGGGccagtttttcaaaaaatattcaaacagTCGTCTCGCTGGAGACCATTGATCTGTGCCGGTGCTCGTCGAAGATCGTCGAGAGCCTGTTCGAGACAAATCCCAACCTGAAAGTCATCAATGCAGTGACTATCAAGGATGAGACACTAAATCTAGAGAATTTAAATCGGTTAGAAAATCTAGAGGAACTGAGACTAAAATCAATCGATGGGTGTTCGCTAGAGGGTGATTTGTCGTCGATCCAAAGCCTAAAAAATCTGCGGCATCTCTCCCTGACGTCGTTCAGGGAACTGGGCTTAAAGGAGGTTGATGTCCTTGGCGAACTTATCAATCTGGAATCACTAGAGCTTGGGGAATGCAGTGAGTTCAGCACAAAATTCGCAGAAAATGTTCTTCCCAAGCTCACAAAACTGGAACGCCTTCGACTAGAAAAGGGCCAGGCTGAATGCTGCACTCTCGAAATTCTTGATGCTGTCGCTCAACTCCATAAATTAGCTCAATTGGAATTGGTCAACTTTGACGTAAAGATAGGTTTCGACGAAAAGCTGGCAatgtgtaaaaatataaaacgcTTGCTATTAATACCCACATACATTTCACAATCTGCCACAACGAATAATATTGTGCTGAGCGCTGTTTTACAACTATCAGAAACTTTACAGACGCTGACGTGGGCAGTTACGCTGGAACTTCTTCGGGTGACCGCTCTATACGTGGACCAATGTGACAacaagaaaaaagataaaaaattctttgatgAAAGTATTCCGGTACTAAAACCCGTTCCTGGAATCGCTGACGAAAATGAGAAGTCCCAAAAGAATACATCTGATGTGCCCCAAGTTGAAATATTACCACTTGTAAAAGTTGAGAAAATCCTCACCATGGGAATGCCAacaacgaaatttaaaattctgaagGTCCCGTATCACTTCACCTGGCGGCAAAATTTAGTGGATTTACACTAG
Protein Sequence
MDTEITEESTFLVEQKTDTIGSPVHSDYVGGDDSDAKMTLAVTSDEDSRESTRGRNCIEKKDQLGQTEGAKMQVPPNDSNGTIRRKSRANSAEGASSLDKPTTAKRKLSQTEWLSDDEDLLGFDEKSGDPVEEKRFKKIKEDEKEEKEPVKVEEVVKLVEEEKPSVKEEEPETETVKCQLVPKVLEQSKSRIEVEKVHTPLSSKSKVSKDSAYRKPFDMGWKREFVYRAIPGVSKEKGEVYYISPAGKKLRTRNELQQHITPGLTLDNFTFSKEPLGYEEEVIRSAKPTMRSNPSTPTDSNRESLGKRVPKPKAPKGASPPPQGWTASKAVKSAASPRPVPAPRPPEESEPKSTSKTSSAKGGKSVKKGEPCTIQCTLAMGKIPHLQCVKCLCLFHHECVGLDRSEYDRHKTSSESKSAEFPSSNPFRQGRYICELCEKEPNAAQISPTKPVAQSPTKIQSNLATVSTNNAGTGAASGATTVASVTPPVQQQNPATPGNTQRKVSEAGPPPKELKQASSTPKAAVPPTKPSASQSNSNEANIELSAGLPQSIAVIKGRKYVVIRKPCVPHYTRTDDESHSRRNENSTVESSTAPSLQTGDDLPMRKRIPNTRNKFSPDSPAAHQPQQQHLVPASSTSLRPSSESFAANFFSNVSLGYEILFQIFQYLKVQELLRAACVCRVWYVVANNRSLWKTVRMKNSQVNDWTGLAAALRRNETQHLDLRKMLTCSTNADEMWASFSKNIQTVVSLETIDLCRCSSKIVESLFETNPNLKVINAVTIKDETLNLENLNRLENLEELRLKSIDGCSLEGDLSSIQSLKNLRHLSLTSFRELGLKEVDVLGELINLESLELGECSEFSTKFAENVLPKLTKLERLRLEKGQAECCTLEILDAVAQLHKLAQLELVNFDVKIGFDEKLAMCKNIKRLLLIPTYISQSATTNNIVLSAVLQLSETLQTLTWAVTLELLRVTALYVDQCDNKKKDKKFFDESIPVLKPVPGIADENEKSQKNTSDVPQVEILPLVKVEKILTMGMPTTKFKILKVPYHFTWRQNLVDLH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00628371;
90% Identity
iTF_01183844; iTF_00717809; iTF_01461175; iTF_00936548;
80% Identity
-