Mlit002341.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Macaria liturata
Gene Symbol
Rhobtb1
Assembly
GCA_964023185.1
Location
OZ026806.1:15056141-15073247[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2.9e-06 0.001 19.8 0.3 5 44 258 296 255 317 0.84
2 3 0.00029 0.1 13.4 0.3 47 109 394 463 385 464 0.74
3 3 7.4e-18 2.6e-15 57.1 0.2 6 107 488 588 484 591 0.93

Sequence Information

Coding Sequence
ATGGACAACGAACAGCCCCATCAAGAGCTGGTAAAATGCGTGGTTGTCGGAGACACGGCTGTGGGCAAGACCCGTCTGATCTGCGCCCGGGCTTGCAACAAACATGTGTCGCTGTCTCAGTTGATGACCACACACGTGCCAACGGTGTGGGCTATCGACCAGTACAGGATTTATAAAGATGTGTTGGAAAGGTCCTGGGAGGTGGTGGATGGAGTGAATGTGTCCCTGCGGCTCTGGGATACCTTCGGGGACCATGAGAAAGACAGGAGATTTGCATATGGAAGaTCTGATGTGGTACTACTCTGCTTCTCCATCACAAACCCCATATCTCTGAGAAACTGTGGCGCTATGTGGTATCCAGAGATCAGaCGCTTCTGCCCAAACACTCCCATCCTGCTGGTGGGCTGCAAGAACGACCTCCGCTACATGTACCGAGATGAGACTTACTTGAACTACTGTAAGGATCGAAGCCCTTTCATCAGGGCACCAAGAAAGAGCGACCTTGTAATGCCGGACCAGGGGCGCGCGTTGGCTCACGAGCTGGGCATATACTACTACGAGACATCCGTGTTCACCTACTATGGAGTTAACGAGGTATTTGAGAACGCGATCAGAGCTGCCCTGATGGCGCGCAGACAGCAGAGGTTCTGGATGACTAACCTGAAACGTGTGCAGAGACCGCTGTTGCAGGCCCCGTTCCGTCCGCCGCGTCCCATGGAGCCAGACATCAATGTAGTGGCCAGCGTCTATCTGGAGAACACCACTGCTTTGCTGCATCACCAGTATTTCTCAGACATGGTAATCATTTGCGGTGCGAAGGGCTTCCCGGTACACAGGTTCATGGTGGCCGCCGCGTGCGAGGCGTTCCACCGCCTCCTCACCACCGACTGTGTGAGCCTGTCTGCTGAGCTGGCCAGGAGCTCCAGCGAGAGCAGCATGGTAAGCAGTATGGGAGAAGCCACAGCGGGAGAGTTCAATGAAGATACTGAATATTTGATCAGTAAAGAGCAAGCCAAGCAAATGAGAGTCTGGGACCAGATAAAGCGTCGCTCCTCCTGCCAGATCCTGCCTCTAAGTGACAGTTGCAAGAAACCACCAGATTTGTACAGGGAGGTCAACCACCCCGCTATCAACTCTATACGGGTTGTTAAGTGCGACAAGATCCAACACGCCACCTCGCAAACGCAAACAATAGTAACGATGAGCAAGTTGATATCTCAAGCTGTGATGCAGGAGATAATAAACTTCATCTACACAGGCACTCTGGACAGCGCGGCCTTCAAACAACAGTCCGCAGCTATTGGATTATTACtgGAAATCAGACAAGCGGCAGAGCTACTAGGCTATCATGAGTTGACGAAGTTAACACAATTCATACTCGACCAACACCTGCTCTTCGATAAGGGATTCATGCTTAACTTCCATGGGCCGTTACCGCAAAGACTGCGCGAGATGTACGTGGAAAACCACCTGTTCGCTGACGTCACCTTTGACCTGGATGATGGCATACATCTGGCGCACCGAGCCATACTGATGGCCAGGTGTGACCCCATGAAGGCCATGTTCCAGGGACATTTCAGGGAAAGCACCTCGAGAGTGATATCCTTCCCGGGGGTCAAGATGTACGCGTTCCACATCCTGCTCTGCTACATATACAGCGACAAGATCCCGTGCGTGGAGCCAGCTCGGTGCCTGGAGCTGCTGGAGCTGGCCAACCGGCTGTGCATGACGCGCCTCGTCACGCTCGTCGAGACCAAGGTGCTGGACCAGCTGCAGCGCAGGGACAGaGTTTGCGGTGAAGACGATCAAGTGGTCGAAATAGCGCTGTCTTTACTAGAACCAGTGAAATTACACAACGCCCATGGTCTCGCCGAGTGGTGCCGCTGGCGCCTGTGCGGTGCGTACGACCGCGCGTGTCGAGCCAAGCACCTCTCTGCCGCCTCCAGGGACTACCTGTCCGACAACCGCTGGCCGCCAGTCTGTGTACGCCTGTGCGGTGCGTACAACCGCGCGTGTCGAGCCAAGCACCTCTCTGCCGCCTCCAGGGACTACCTGTCCGACAACCGCTGGCCGCCAGTCTGTGTACAGTGTACGCCTGTGCGGTGCGTACAACCGCGCGTGTCGAGCCAAGCACCTCTCTGCCGCCTCCAGGGACTACCTGTCCGACAACCGCTGGCCGCCAGTCTGGTGAGTGGACATACAGTGTACAGTGTACGCCTGTGCGGTGCGTACGACCGCGCGTGTCGAGCCAAGCACCTCTCTGCCGCCTCCAGGGACAACCTGTCCGACATCCGTTGGCCGCCAGTCTGGTACGTGAAGGAGTACGACTACTACCAGAAGTGTCTGACGGAGCGGAACAAGGAGCAGAAGGAGCTGCGCCTCACCACCTCGCTGCAAGCAAGCCAGCACACTGGGTGCCTATGTTTCTCGAGCAAGGTGCGTCGCTCGAGCTCGGCGGGAGCGGACGTGGCAGTCCCGCTGTGTCGGCCGCCCGACGCGCCGCCGCAGCCCGCGCCGCCGCAACCGCTCTGA
Protein Sequence
MDNEQPHQELVKCVVVGDTAVGKTRLICARACNKHVSLSQLMTTHVPTVWAIDQYRIYKDVLERSWEVVDGVNVSLRLWDTFGDHEKDRRFAYGRSDVVLLCFSITNPISLRNCGAMWYPEIRRFCPNTPILLVGCKNDLRYMYRDETYLNYCKDRSPFIRAPRKSDLVMPDQGRALAHELGIYYYETSVFTYYGVNEVFENAIRAALMARRQQRFWMTNLKRVQRPLLQAPFRPPRPMEPDINVVASVYLENTTALLHHQYFSDMVIICGAKGFPVHRFMVAAACEAFHRLLTTDCVSLSAELARSSSESSMVSSMGEATAGEFNEDTEYLISKEQAKQMRVWDQIKRRSSCQILPLSDSCKKPPDLYREVNHPAINSIRVVKCDKIQHATSQTQTIVTMSKLISQAVMQEIINFIYTGTLDSAAFKQQSAAIGLLLEIRQAAELLGYHELTKLTQFILDQHLLFDKGFMLNFHGPLPQRLREMYVENHLFADVTFDLDDGIHLAHRAILMARCDPMKAMFQGHFRESTSRVISFPGVKMYAFHILLCYIYSDKIPCVEPARCLELLELANRLCMTRLVTLVETKVLDQLQRRDRVCGEDDQVVEIALSLLEPVKLHNAHGLAEWCRWRLCGAYDRACRAKHLSAASRDYLSDNRWPPVCVRLCGAYNRACRAKHLSAASRDYLSDNRWPPVCVQCTPVRCVQPRVSSQAPLCRLQGLPVRQPLAASLVSGHTVYSVRLCGAYDRACRAKHLSAASRDNLSDIRWPPVWYVKEYDYYQKCLTERNKEQKELRLTTSLQASQHTGCLCFSSKVRRSSSAGADVAVPLCRPPDAPPQPAPPQPL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00207106; iTF_00649251; iTF_01172516; iTF_00825926; iTF_00033034; iTF_00125230; iTF_00206222; iTF_01208400; iTF_00033937; iTF_00818452; iTF_00044629; iTF_00896053; iTF_00666648; iTF_00926745; iTF_00634618; iTF_00143163; iTF_00913735; iTF_00635526; iTF_00650164;
90% Identity
-
80% Identity
-