Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 4.8 2.7e+03 -0.3 0.1 79 107 107 136 101 139 0.80

2 3 3.5e-22 2e-19 71.0 0.2 11 108 191 288 183 290 0.93

3 3 0.53 3e+02 2.8 0.1 78 108 290 320 283 322 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	4.8	2.7e+03	-0.3	0.1	79	107	107	136	101	139	0.80
2	3	3.5e-22	2e-19	71.0	0.2	11	108	191	288	183	290	0.93
3	3	0.53	3e+02	2.8	0.1	78	108	290	320	283	322	0.85

Coding Sequence: atgtatgaaCCACAAACGAAAACCTCAGCTGCACAGGATGACAATAAAATCAATGTCACGGACTCTGAAGTAGTGTTTGGCCATCAGATAGTTCAAACGCGTGATGTAAATTGGTTATGCTTGGATGAGATATATGAAAAGTTCTATCGACCCAACTTCTACGATGTCGGCGGCACTCATACACAGGATGTACCAGACTACTGGTTTACATACAAGACAGAGCAAGTCGGCAACATTTTCCTTCTAcacttatttatttgtaatcatGGAGTGGATTCGTTTAGGGTAGCAGTGAGTTGCAGCAATCAACTCAAGATTGACAAGAAAAAGGACATTGTATATATTCAGCAATTGTTAAAAGAATTTCAATTCAAAAAAGTTTCACATCTCTCTCAAAATTACTTAACTAGCTATAGCTTTTCAGATCTTGATGTAGAATGTTTTAAAGACAGAAAGTTGTATATAGCAATATCATTTGCTTTTGGCAATACTGACGGTATTGGGCTTGacatcattaataatattaaattgaatcATGACTGTGGTGCTCTCTTGTTGGACCCAATTGGTTCAGATTTTACTATAgaatcatcagatggagttaagtTTCAGGTCCACAAAGTCATATTAACTGCACACAGTGAGGTGTTTAAAGCAATGCTCAAAGAGGATACCGCAGAGAGTCAGAATAATTATGTTAAGCTTGTTGATGTAGGTGAAGATGATCTTCGTTATATGCTAGAATATATATACACAGGAACAATAAAATATGTTGATAGTATTAACTTTGCTTCTTTACTAATGTTAGCTGATAGATATAACTTGCAAGGTCTTTGGAAACTATCACAGTATGTCCTTTCAGAACAAATTAATTGTGAGAATGCTctagatatattaataatagctgATATGTATGATTCTGATTTTTTAAAGATTGAAactatgaaatttataaaaagaaatgtagAAATACTACAAAATAGCACTTTCAAAGAGATTAATAATGCTAGTTTGATAAGAGAATTATGCACATACCTGGCTTCATAA
Protein Sequence: MYEPQTKTSAAQDDNKINVTDSEVVFGHQIVQTRDVNWLCLDEIYEKFYRPNFYDVGGTHTQDVPDYWFTYKTEQVGNIFLLHLFICNHGVDSFRVAVSCSNQLKIDKKKDIVYIQQLLKEFQFKKVSHLSQNYLTSYSFSDLDVECFKDRKLYIAISFAFGNTDGIGLDIINNIKLNHDCGALLLDPIGSDFTIESSDGVKFQVHKVILTAHSEVFKAMLKEDTAESQNNYVKLVDVGEDDLRYMLEYIYTGTIKYVDSINFASLLMLADRYNLQGLWKLSQYVLSEQINCENALDILIIADMYDSDFLKIETMKFIKRNVEILQNSTFKEINNASLIRELCTYLAS*

Sequence clustering based on sequence similarity using MMseqs2