Lnic025461.1
Basic Information
- Insect
- Luperina nickerlii
- Gene Symbol
- -
- Assembly
- GCA_963855955.1
- Location
- OY979679.1:18541845-18542378[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.1e-09 2.5e-06 28.7 0.1 24 70 9 55 4 65 0.90
Sequence Information
- Coding Sequence
- ATGGATACTACACCTATAGAAGCGGCACAAATCGTCGCCCTATTGCAAGAAGGGCTCAGCCAGCGGGCTGTCGCACGTCAGCTCCACATAAGCCAGTCCTGTGTTTCGAAAGTTTATAAACGCTTTCGGGAGACTGGTGGCTTTATCCCGAGACCAAGATCTGGACGGCGCCGGTGCACATCGGAGAGGGATGACCGCTTTATCGTGTCAACCTCTCTCCGAAATCGACATTTGACTGGTGTCGACGTCCAACAGGAGCTCCGAAATGTTCGTGGGGTAGCTGCCAGCGAATGGACAGTTCGTCGAAGACTTAAGCAAGCTAATTTGACTCCAAAAAGGCCTGCCACAGGCCCGAAACTGACAGCAGGTCACCGACAAGCACGCCTTCAATTTGCTCGCTACCATCTTGATTGGGAGGTTGAGCAATGGAGGCGAGTCCTGTTTTCCGACGAGTGCAGAATGTGTTTGCACGGCAGCGACCGAAGGGGTCTACAGGCGGCCTGGGGAGCGATTTGCGCAGTGCTGTTTCGCTGA
- Protein Sequence
- MDTTPIEAAQIVALLQEGLSQRAVARQLHISQSCVSKVYKRFRETGGFIPRPRSGRRRCTSERDDRFIVSTSLRNRHLTGVDVQQELRNVRGVAASEWTVRRRLKQANLTPKRPATGPKLTAGHRQARLQFARYHLDWEVEQWRRVLFSDECRMCLHGSDRRGLQAAWGAICAVLFR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00928665;
- 90% Identity
- iTF_01021185; iTF_01021182; iTF_01021183; iTF_00924643; iTF_00924644; iTF_00924642; iTF_00924645; iTF_00924652; iTF_00924655; iTF_00924638; iTF_00121414; iTF_01104299; iTF_01104298; iTF_00832909; iTF_00832902; iTF_00832903; iTF_00832904; iTF_00832969; iTF_00832911; iTF_00832912; iTF_00832943; iTF_00382579; iTF_01332636; iTF_01332635; iTF_01332637; iTF_00928665; iTF_00172925;
- 80% Identity
- -