Lser000066.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Lucilia sericata
Gene Symbol
Baz2b
Assembly
GCA_015586225.1
Location
NW:9253-25791[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.7e-12 1.3e-08 34.0 0.0 5 75 943 1013 941 1015 0.90

Sequence Information

Coding Sequence
ATGAAGAACATGGATAAAAATGCGGGTGAGGGTGGACAACAAAATGATGGTAAGGGAGGCGGCGGCGGTGGAGGTAAATCTTCCGGCAATACTGGTGCTGGTGGGGCAGGTGGTGTTGCACATGATCCTGCTGCTTTATTAGATGCGGCTTCTCTTTTTGctTATTGGGGCCGTGATCCAACCGCTGCTGCCGCAGCAGCTGCTAATCCTTTATTTAACGCACAATTTAATGCTGCAGCCGCTGCCGGCTTGGGTTTACTGCCCAATCCCACTGCTTCTGCTGCTAATGATCGTTATTCCATGGCGGCAGCAGCTGCAGCGGCCGCTGCTGGTCATCATCATCAAAATACCATGGCGGTGGCCGCTTCTCAAGCTGCCAGTTTGGCCGGTTTACATCCAGCAAGTTGGTGGTCAATGGCTCAATTAGCTGCCCAAGACTATTTTAGTCGCTTACAAGCCTCTGGTTTATCACCATTTCCCCATCCTGACTTGGCTGCAGCTTTTGGGCCGGCTGCTTTAGGTTTAGGTACTGCTGGTGCTGGAGCTGGTAACAGTGGTGGTGTTGGCGGCTCTACTGGTTCTGGAACACAAAATTCCAGTACAAGTGGTAATTCAAGCTCCAATATTGGTAGTACATCATCATCGGGCAGTAAATCGAGCAGTAAGTCTCGTAAAGAAAAGCAAcgtcaacagcaacaacaacaacagcagcagcaacagcaattgcaacaacagcagcaacaatccTTGGCCAATAGTTTAAATGCGGCAGCTGCCGCAGCAGCGGTGGCCTCTAATCCGGCGGCCGCTTTAGCAGGCATGCATTTGGTGGGAGCGGGCACTACCATAACACCATCAACAGGTTTGGGCAGCTCCTCCAATAgtggcaataataataacaacaacagcagctcCAACTCTTACAAAAATAATTCCTCAAATCTGGGTAAAAACTCAGGCTCATCAACGTCTTCTACAATCTCTGTACAATTGCCTCCTTCGCCGGGTTCAGCTTATGATCCGGTTGTCTTGCACAAAGAACTATTGGCTATGCAAGTGGCTGCTGCCGCTGCTGCTGCCAATCCCTCTTCTtcatcctcatcatcatcatcgaagAAATCAAGGAATTCTTCTTCTAACAATTCTTCCTCTTCCCATCATTTAATGGGTTCATCTTCGGGAAATAATAACTCTTCAGCTGGAGGTCTTATGTCAACACATGGTTCTTTAAGCGGAAGTGGCGGGGGTGGAGCTGGTGGTGGTGGTATGAGTGGCTCATCATCTTCATCGCGTAATAAGAATGATGATAAAAATAATGCCTCCTTGAATGCTTTGAATTCATTGTCACAATTTGGCACTTTAGGCATGACACCGCAACAGAGTATGCAAGCCGCCATGAATGCTTTTGCGGCCAGTAACGCTTctgctgcagcagcagcagccaaCAATGCTGGTAATAATGCGGGAGTTAGCTCATCGTCCAGCACATCCTCTTCCACGGCTGGTAATAAGCAATCAGTTAATGATTTTATGCCCTCCGGAGGATTAGGTGACCATCCATCGCTGTTGGGAGTACGCTTGCCACCCGATACGGAAATCATCAAATACACATCATCCATCGTGGGCCCCAAAATACCCGGTACTACTACACGTGGTCGTAAAAAGACCATTTCTGATCATGATCAAAcactacaactacaacaaaacaaaacaaatgtatCAGATTCAAAAACATTTTGCATTGCATTTTCAGGTCTTAGCCCGGCGAAAAGGGCTAGACTCGAAATGGAGTATGCTGCCATAGCTGCCGCAGCCAATGCTGGCCCCGGACCCAGTCTACCTCCCACACTGACGGCAGCCCAGATAGCTGCACTGAGTGGCCTGGGTGGAGGAGCGAGTAGCACATCAAAATCTTCGGGCGCCTCGGCTGCCTCATCGTCACAGAGTACGCCACACTTGGACTTGACCGGACCGAGCAGTGGTCGAACGAGCCGAGACTCGTCGTCGGATCGAGTGGAGGTCATTAAATTGCCACCTACTATTACCTCGAATGGAGCGTATAATTTATcgaataaaaataaagatataCACGATTTAAGCGGTACAACTGATCTTAACTCGGGCGTTAATCTTAGTTTAAAACCGGCTGCTTCTTCAGTATCGAATACATCGCTCGCCAATACGAATGTTGCCGGAGCTACCATTACTATAGAAGATTTTGATGCTCCGCTTAATTTATCCATGAAACCAGATAAATCATCAGCGTCTAGTAATGATTTATCGGGTAGCAGTGGCAGTGGCGGTTCTGGTGGTAATAACTCTGGCAATACGGGTTCAAATAGTTTACAAAGTTTAAGTTCCATAACCGCAGCTCTAGGGAGTAGCGGTGGTGGCGGTATCGGTATGAGCGGTAGTGGTGTCGGTGGTGGTAATGGTGGAGCAGCAGCAAATAGTTCCAATACTGGAGGTAATAGTAGTAGCAATTCCTCTTCAGccagtggtggtggtggtggtggttgtGGTATGGGTAATGAACGCACCAATCAGCCACCATTCAAAGAGGGACGTCCTAGAAATTTGGGTCGTGGTGTCTCGAAACCCAAAAAGAATACGGTGGCCTCGCTACTCGCTCAATCAAGGGCAGTGGGTATCAAACCCATGCTATCCACTCAACAATTATTGCAACAAGGCGCTGATATAGAAAAAATACGTCAAGCCTTAACAGAAGCTAATGCTCAAATGGAGGTTTCCACCGACTCAGAAAGTATTGCTGCTGAAAGCGGCTTATCAGAATCGGAAAGTGAGGAGCCTAATCTTTTAAATGTAACCGAACTGCGAATACCCTTAGACTTAGGCTGGAAACGTGAAACAGTAATTAGAGGTCTTACCAAGGCGGGACAAATCAAAGGAGAAGTTGTTTACTATGCACCCGGCAGTAATGTACCCCTTAAAACTATGGGGCATGTTTTCTCTcATTTAGAGAAGAATCCTTCGAAATTGACACGAGAAAACTTTAGTTTCTCAGCTCGAGCCATAGTGGGCTCTTTCTTACAACCGGCACCACCACCCTATGCCAATGATGGTGATTACATACGCATGTCTGATGAGGATGTAGCCAAACGTTTGGAagatttaaaaatctttacacGACAAACCCTAAATGTAGAACAACGCATAGAAATTGCCAAACAACAGCAGGCCTTAAGAGATGCCAAGAAATTACAAAAAGAGGAAATGGCACGCAACAAGGAAAAGGCACGCTTAGAGAAAAATGAAAAGTTGGAACAGCAGCGCAaagaaaaagaattgaaaaatcAACAAGCCATAGAGGCCCGCAAAAAGAAACAAGAAGAACTAGAGCGTCTTAAACAGGAGGAAATACTCAAGAAGCAGCAGgaACTTAATCGTCAAAAGGAAATGTTATTGGCCGCAGAAATGGAAAGAGAACGTAGACGCCAGCATATGGCTTTAATACGTCAATTGGAATTGCGTCGCAAATTTGAGGAACGTGAAAAGAAGAAACATCAAATGGTCTTGGATCGTTTGATTTTAAGAGAAAAACGTTTGGCAGCTCGTAAACGAGATGCTGAAATTTTAGCACAAATAAGAAAACCTCAAGAGGATTCGGAATTATTGCAATTACATGCTATACCCGATTTAGAGCGTATTGCTGGCAATCGTTTGCCTGGTCAAGCTATGGCTGATCTATTAATGGTCTTTGAATTCTTACATAACTTTGGTGAAACATTAGGTTTTGACATGGAATCTCTACCCACCCTGCAGAATCTCCACGATGCTTTAGTAGTCGATAGTAATGCTGAAGTCGAAGAAGAACTCTTATCTGTGATGACACATCTACTGGTATGTGCCATAGAAGATCCGGGCATACCAAATCCGGGACGTCATACCACCCTACTGGGACAATCTCTACGTAATGCCGACATTACAAATTCCAATGTATCGGAAATATTACGCATCTATTTGTATGCCACTGCAACCGGGGAGATACGACAAATGTTTGGCGTTGTTATGGATCGTGAACGTGAACGTAAAGTACCGGATCATCATCAAATCGATGCGGAAACTATAGTGCATACTGGCAAAAACGCTGAATACTATAAGCTATTGCATGAGAATGAAACGTGGAAAATGTCTTTGGCTCTAAAGGATCGACCATTTGTGGCTCTGAATCCTACaaagaaaacacaaatattAGCACATCTCTGCAATGATTTGCTCATGAATAAGGCGGTACTCAAACAAATCGATAATAGTCTAGAGACCTGCAATCAAATGCGCAAAGAAAAGTATATGACCGATATGAAAGTGAGGAAATATAAGGCTCTACACATGCGCAAATCGAGAATTGAGGCTTATGAGAAGATACAAGCTGAACGTGAAGCAGCCATGCAGGCGATGGCACAACAACAGAAATTAGATGCTGAACGTTTAGAAAAGGAATCAGTCGATGAAGCCAATAAAAAGGAGGGAGCTAACTCGGAAGATAATATGGGAGCGGCAGCCACCTCCGCACTTGAAACAGCAGGCgaacaaaataataacactAGTAAGGATGAAACCATGGAAGTGGATTTAGATGGTTCGCAAAAACAAAACGATAAAGAATTAACCAACCTGCCTAGCAATTTGGATGAAGGAAAATTGTCGGCCGCTAACTTAATGGGCTCAAGTGATATAACACCCACTAAAATGGCCAAATTGGATGAATTAACTTCTACTTCGTATCATAATGGTGGAGCCTCTACGGGTGATATTAATGCTTTATTGGGTGGCAAGAAAACCATAAAGGGTCTCAATGATGATGCCTCCACCGATGTGGGCATGGATGAAGATCTTTCTGATATAGAGTCGGAAATTACCAATGTAGAAGAGGATGAAGATAATAGACTATCGGCTGATGAATTACAAAAGAAGTTGGATAAAATCATTAGAGCCTCCTTGAACTGTAAAGAAGTGTTGGAGAAGAGCACAAATCAACTAAGAGCCACATGTTTCGGTCAAGATCGTTTTTGGCGTCGTTACTGGCGTCTGCCCAAGGCAGGCGGTATATTTATAGAAGCTTTAGAATCGGCTCAAAATGATATATTCCGTTTCCAAGAAATTTTAGAGCAAGAAGATGAGGAGCGTAAAGAAAACATGAGTCCAGAACCTTTGGCACAAGATGTCACTAAGAATTGTAATGACAAACCCGAAGATAGTTTGGATGTAGAAATGAGAGAATTGGAGGCATTAACGGCTGTTAACGCCAACCAACCACCAGCACCGCCAACAGTGGAAAATGTTATTGATAACAATCCAGCTGATGACTCCGACGATGATGTCATCGAAACTAATCGCATAGAACCCGAAATAGTCGATTTGcgtgatgacgatgatgatgattatgatgtGGCCATACAACCGCATGGCATACAATTGGATAACAATGGTACCGCCAAAGTGGAGAAACCCGATGCTGCTGGCCTCTTGCCACCGGCACACATTATAAATCAGCTGCCTAAAAAGGAAGAAATGGAAGTAGACATGAAAGTACCACTACCACCACCGCCCTCCTCTTCCTCTGCTCTCCATCAGCTAACCACAACTCCACACATGACGAATCTTAATCAGCTGCAGAATTCAATAACTATAAACTGTGATAAACCAGATTTGAATAAAATGAATTCTTCTGCTACTTCTATGGCTAACACTACAACTTCCATGATGTCTAATCCCACCACATCCATcaccaccaccaacaacaataacGGCAACTCTAGCATAAATCTTTGCACCAGCAATAGTGGCGCCACTAAGTTTGAGGACAAAAAAGAAGACGATTGTATAATTGTCTCCTCTACAGGACCCTCGGATGTTAAACCTCTATTCACTAGCGAAATACCCGAAGTCAAGTGGTTTTCCATTGTTAATCGTGAAGTGCCATTGACAACCACAGAACCTCAGAATGCCACCAATCTAAAGGAATTCCAAAAGATGTTTGCCAATATCACCTGTGGCTCTAGCTATCAAATCCAGGGCCATCCCTGGGATATCTCGAATAATGTGCAGTATTTCACCGTTACCATGGATGATTGTAAGGCTGATCTAACGAAATTAACCACGGAATGTATACTATCCTTGTCCGGGCTTAATGAGGCCGACATCGAAAAGAAACTTAAGGAATTTgaggaaaaattacaaaattcaaaaaactcCTTGGAGACTCCTCGTCATCATTCTGCAGCAACGATGAAAAGTGAAGATGTAGCAGATGTAGAAGGTAAAGACAATAACAATATGGAATGCGATGACGAGGAGGGGGAGTTGCGTGGTGGCGTTGAAAAgaaatttgtgttaaaaaacgaaagcaaaatgaaattttttccttttcctAAGGACTCACTCTGCGACACTGGCGGAGGTGTTGTAGGAGCAGGGGTGGAGGCGGAATTTGCCGAAGACATTAAGCCCAAATTGGAAATAAAATTGGATGAGGCTTTACAAACATCCCTGCAGAATATGCAGCAAATGTCTTTGGCTAATATAAGCAATTTTATACAATACGATATACCCACTCCTTTGCAAATGTCTCTGGAAGAATCTCAAATGTTGGAGGAAATCAAGAGAGAGGGGTTTCCTAAGAAACAAAAGGGATCTTATGTAAAACGTAACTTGCGCTATGGTTGGTGGAAAATCGATACCATGGAATTGCTACAGCAGGTTATAAATTCTCTCAATTCCACGGGTTTAAGAGAAAAAGAACTTAAGGAAAACCTAACACGTTTTTTGACCCAGGAAATACCTTTGGGTCTACCCTATCCCATGGGTGAAGTAAGACCGGATGATAAAGATTATCTATTGCCGGATAAACCCAATGATTGGACTCCCAAAATAGCTAAACGAGTAGAAATGGCTTTATTGGAGCAGCTAGAAGTATTAGAAGACAAAATCGCTTCGGCCTCTATGCAATTGAAACACTGGCAATTGCCACCCAGAATAGAATCCGAACTTAATCTAGAAAGTGATGCTGATATTACCGAAGAAGACTTTGTTAGTATTATACCCATGATTAGAGAACGTATTATAGACTTGGAAGCCAATATAGAAAGGAGATATTTGAAACCACCCTTGGGTGCTCAAACGGGTGATGCCCATTTAGCGGCCATTGctcaaaatcaacaaaatacTCAAACACAAAATTCCGCCAATGCGGCTGCCTATTACCAACAaatgcaacagcagcaacaacaacaagctttgctgcagcaacagcaacaacaagccTTTAATCCATCGGCTTTTAATGAACGAGCCATGGCCATAGCAGCTAATAATGCCAATAATGCAGCCAGCAGCAATTCAAATGCCAACAGCAGTAGTGCCGGCGGCGAACTTAATTCACAAACGCACTCCTCGGCCAACAACGAAAATAATTCCGGAGGCGATTCTCCCTCCAGTAATTGTGATAGTGATAAAGATGAAAAAGTGGAAAATATACCCAAAGGTTTGGTGTCTTGGCGTGATGCTGTTTCACGTTCTCATACCACCGCCCAGCTGGCAATGGCTCTATACGTTTTGGAATCTTGTGTTGCCTGGGATAAAAGCATTATGAAAGCCTTGCctttaacaacaaaaaccgGAAAAAACGGAAAAgtctaa
Protein Sequence
MKNMDKNAGEGGQQNDGKGGGGGGGKSSGNTGAGGAGGVAHDPAALLDAASLFAYWGRDPTAAAAAAANPLFNAQFNAAAAAGLGLLPNPTASAANDRYSMAAAAAAAAAGHHHQNTMAVAASQAASLAGLHPASWWSMAQLAAQDYFSRLQASGLSPFPHPDLAAAFGPAALGLGTAGAGAGNSGGVGGSTGSGTQNSSTSGNSSSNIGSTSSSGSKSSSKSRKEKQRQQQQQQQQQQQQLQQQQQQSLANSLNAAAAAAAVASNPAAALAGMHLVGAGTTITPSTGLGSSSNSGNNNNNNSSSNSYKNNSSNLGKNSGSSTSSTISVQLPPSPGSAYDPVVLHKELLAMQVAAAAAAANPSSSSSSSSSKKSRNSSSNNSSSSHHLMGSSSGNNNSSAGGLMSTHGSLSGSGGGGAGGGGMSGSSSSSRNKNDDKNNASLNALNSLSQFGTLGMTPQQSMQAAMNAFAASNASAAAAAANNAGNNAGVSSSSSTSSSTAGNKQSVNDFMPSGGLGDHPSLLGVRLPPDTEIIKYTSSIVGPKIPGTTTRGRKKTISDHDQTLQLQQNKTNVSDSKTFCIAFSGLSPAKRARLEMEYAAIAAAANAGPGPSLPPTLTAAQIAALSGLGGGASSTSKSSGASAASSSQSTPHLDLTGPSSGRTSRDSSSDRVEVIKLPPTITSNGAYNLSNKNKDIHDLSGTTDLNSGVNLSLKPAASSVSNTSLANTNVAGATITIEDFDAPLNLSMKPDKSSASSNDLSGSSGSGGSGGNNSGNTGSNSLQSLSSITAALGSSGGGGIGMSGSGVGGGNGGAAANSSNTGGNSSSNSSSASGGGGGGCGMGNERTNQPPFKEGRPRNLGRGVSKPKKNTVASLLAQSRAVGIKPMLSTQQLLQQGADIEKIRQALTEANAQMEVSTDSESIAAESGLSESESEEPNLLNVTELRIPLDLGWKRETVIRGLTKAGQIKGEVVYYAPGSNVPLKTMGHVFSHLEKNPSKLTRENFSFSARAIVGSFLQPAPPPYANDGDYIRMSDEDVAKRLEDLKIFTRQTLNVEQRIEIAKQQQALRDAKKLQKEEMARNKEKARLEKNEKLEQQRKEKELKNQQAIEARKKKQEELERLKQEEILKKQQELNRQKEMLLAAEMERERRRQHMALIRQLELRRKFEEREKKKHQMVLDRLILREKRLAARKRDAEILAQIRKPQEDSELLQLHAIPDLERIAGNRLPGQAMADLLMVFEFLHNFGETLGFDMESLPTLQNLHDALVVDSNAEVEEELLSVMTHLLVCAIEDPGIPNPGRHTTLLGQSLRNADITNSNVSEILRIYLYATATGEIRQMFGVVMDRERERKVPDHHQIDAETIVHTGKNAEYYKLLHENETWKMSLALKDRPFVALNPTKKTQILAHLCNDLLMNKAVLKQIDNSLETCNQMRKEKYMTDMKVRKYKALHMRKSRIEAYEKIQAEREAAMQAMAQQQKLDAERLEKESVDEANKKEGANSEDNMGAAATSALETAGEQNNNTSKDETMEVDLDGSQKQNDKELTNLPSNLDEGKLSAANLMGSSDITPTKMAKLDELTSTSYHNGGASTGDINALLGGKKTIKGLNDDASTDVGMDEDLSDIESEITNVEEDEDNRLSADELQKKLDKIIRASLNCKEVLEKSTNQLRATCFGQDRFWRRYWRLPKAGGIFIEALESAQNDIFRFQEILEQEDEERKENMSPEPLAQDVTKNCNDKPEDSLDVEMRELEALTAVNANQPPAPPTVENVIDNNPADDSDDDVIETNRIEPEIVDLRDDDDDDYDVAIQPHGIQLDNNGTAKVEKPDAAGLLPPAHIINQLPKKEEMEVDMKVPLPPPPSSSSALHQLTTTPHMTNLNQLQNSITINCDKPDLNKMNSSATSMANTTTSMMSNPTTSITTTNNNNGNSSINLCTSNSGATKFEDKKEDDCIIVSSTGPSDVKPLFTSEIPEVKWFSIVNREVPLTTTEPQNATNLKEFQKMFANITCGSSYQIQGHPWDISNNVQYFTVTMDDCKADLTKLTTECILSLSGLNEADIEKKLKEFEEKLQNSKNSLETPRHHSAATMKSEDVADVEGKDNNNMECDDEEGELRGGVEKKFVLKNESKMKFFPFPKDSLCDTGGGVVGAGVEAEFAEDIKPKLEIKLDEALQTSLQNMQQMSLANISNFIQYDIPTPLQMSLEESQMLEEIKREGFPKKQKGSYVKRNLRYGWWKIDTMELLQQVINSLNSTGLREKELKENLTRFLTQEIPLGLPYPMGEVRPDDKDYLLPDKPNDWTPKIAKRVEMALLEQLEVLEDKIASASMQLKHWQLPPRIESELNLESDADITEEDFVSIIPMIRERIIDLEANIERRYLKPPLGAQTGDAHLAAIAQNQQNTQTQNSANAAAYYQQMQQQQQQQALLQQQQQQAFNPSAFNERAMAIAANNANNAASSNSNANSSSAGGELNSQTHSSANNENNSGGDSPSSNCDSDKDEKVENIPKGLVSWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKALPLTTKTGKNGKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01235735;
90% Identity
iTF_00199879; iTF_00921432; iTF_00258880;
80% Identity
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