Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.4 1.2e+03 -0.8 0.0 1 13 9 21 9 22 0.89

2 3 9.6e-08 0.00029 20.4 0.1 34 55 58 79 53 84 0.89

3 3 8.4e-06 0.026 14.2 0.0 28 76 83 142 75 143 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.4	1.2e+03	-0.8	0.0	1	13	9	21	9	22	0.89
2	3	9.6e-08	0.00029	20.4	0.1	34	55	58	79	53	84	0.89
3	3	8.4e-06	0.026	14.2	0.0	28	76	83	142	75	143	0.88

Coding Sequence: ATGCAAATGAATCCGAGTGTGACAATTGAACGCAAACGCGTCGATTGTAGTGCACTGCCCAAGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTCTATTACAGTCCAACAGGCAAAAGAATTGAAAGCAAACCACAATTAGCTCGTCAATTGGGCAGCGAAATTCGCGCCCTACGCACAGATGTCTCCCTGGTGCCACCCATACGCCAAACTGCCTCAATTTTTAAGCAACCTGTCACTGCAATTCGCAATCATCATCAGGATTCCGGCAAAGTCAAACACGATGCCAAACATGGTGCCCAAGAGAAGCCGAAACAATTGTTCTGGGAAAAGAGGCTGGAACGATTACGGGCGTGCCACGACAATGGCGAAGAGCTAGACGACATATCACTGCCCAAAACCATACGCACCGTGGGACCCAATGTCAATGAACAGACTGTCCTGCAATCGGTGGCCACCGCCTTGCATATGCTCAATGCCGGTGTCCATGGTCAGAGCAGCACTAAGGCTGAGCTAACCAAGAATGCGATGGCATTCATGAATCCTGAACAGCCATTGATGCATGCGGTTATAATTTCCGAGGATGATATACGCAAGCAGGAGGATCGTGTGAGTGTGGCGCGACGAAAGCTACAGGATGCTCTGAAAACATGA
Protein Sequence: MQMNPSVTIERKRVDCSALPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFYYSPTGKRIESKPQLARQLGSEIRALRTDVSLVPPIRQTASIFKQPVTAIRNHHQDSGKVKHDAKHGAQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT

Sequence clustering based on sequence similarity using MMseqs2