Lmom001031.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Lordiphosa mommai
Gene Symbol
pax6a
Assembly
GCA_018904225.1
Location
JAEIFT010000630.1:16308-31466[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.1e-34 3.8e-31 107.6 0.0 24 125 87 184 75 184 0.92

Sequence Information

Coding Sequence
ATGTTGATAGAGCCGGGCTTGAATCGTGACTTTGGCTCGCTTACGGTTGCAAGTTCTACGCACTGGAAAATGGAGCCACATGCACATGCCCAACGACTGTCAGCGCTGGCCCCACATGCCTCCAGTGTGGCAGCAGCGGAATCGGCGGCGGCAACACCAACAGCGCCGCCAACAACTGTGCAAATACAACAACAAGGCTTTGGAGCTGGCGGTAACAATGGGCCAACAGCGCCCACGCTAGGCGCTTTGATGTCGCAACACCGCCTATTGGAGTTCTCGCGCTTTGGCGGCCTGCGCGGCTATGACATTGCCCAGCATATGCTAACGCAGCAGGGCGCTGTCTCCAAGTTGTTAGGCTCCCTGCGACCACCGGGCTTAATTGGTGGCTCCAAGCCAAAAGTGGCCACGCCAACGGTCGTCTCCAAAATTGAACAATACAAGCGCGAGAATCCAACCATATTTGCCTGGGAGATACGGGAGCGTCTGATCTCGGAAGGTGTATGCACAAATGCCACCGCTCCATCGGTAAGCAGCATTAATCGCATCCTGCGCAATCGTGCGGCCGAACGGGTGGCCACTGAATTTGCACGCACCGCCGCCTATGGCCTGTACCCGCCGCCCCCGCATCCCTATGGCAGTTTCACCTGGCATCCGGCTGGCAATGTGGGAGGAGGCCAATCGGTTCCCCCGCCTCCGCCACCAACGGCTCTATGGCCAGTAGCTGCCCCTACACTTACCAATCTGCCGCCTAGTGCTGGCAGTGCGGCGGCTTCTGTGCCAGGTGTTAGTCAAGGTGGTGGTAGTCTAAGCTTAAGCTCTGCACACCTGTTGAGCGGTGGTGTAGGCTCCACAAATCGAGCCATTTCACCCGGCTCGGGCAGTCACGAAACACTGGAGTCAGCAGATGAGAATCGACACATAGACTCGGACTATTTGGATGACGATGATGAGCCCAAGTTTAGGCGAAATCGCACCACATTTAGTCCGGAACAGCTGGAGGAATTGGAAAAGGAATTTGACAAGAGTCACTATCCGTGTGTGAGCACACGGGAGAGGCTCTCCAGTCGTACCAGTCTGAGTGAGGCGCGCGTGCAGGTCTGGTTCTCGAATCGTCGTGCTAAATGGCGTCGTCATCAGCGTATGAATTTGTTAAAGCGACAACGTTCCAGTCCCGCCAATCCATTGCACTCACAGCAATCGAATGATGCACCAGCCAGCTCGCCCACACCCAGTAATCACAGCAATGCCTCGGCCCCAACTACTCCAGCCGCACCCATATCCATATGTGGCGGTGGGGAACATTCAACGCAATCGCCACAACCGACCGTTGCCTTTCGCAGCCTGGTCAGTTCACCCTCGGCAGCAGCCTTCTTGGGCCTGGCACGACAATATGCCGTGGCCGCCTCACTTACAGTGGCCGAGGAGCAACGCTCACGTTTACATTATCCCACGGCAGCGGGCGGCGAGTGTCCGGCCGTGACCGTTGACAACTCATCATCGGACTCGGATGAGGAGATCAACGTACACGATGATTCCGATGATGAAATCGAAACGCCGGCGGCAAAAGTGGCCCGTCTGTCATCCTCTGATGCGCCGACAACGTTGCAGCTTCTAAAGCATGACCGTTAG
Protein Sequence
MLIEPGLNRDFGSLTVASSTHWKMEPHAHAQRLSALAPHASSVAAAESAAATPTAPPTTVQIQQQGFGAGGNNGPTAPTLGALMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAVSKLLGSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERVATEFARTAAYGLYPPPPHPYGSFTWHPAGNVGGGQSVPPPPPPTALWPVAAPTLTNLPPSAGSAAASVPGVSQGGGSLSLSSAHLLSGGVGSTNRAISPGSGSHETLESADENRHIDSDYLDDDDEPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWRRHQRMNLLKRQRSSPANPLHSQQSNDAPASSPTPSNHSNASAPTTPAAPISICGGGEHSTQSPQPTVAFRSLVSSPSAAAFLGLARQYAVAASLTVAEEQRSRLHYPTAAGGECPAVTVDNSSSDSDEEINVHDDSDDEIETPAAKVARLSSSDAPTTLQLLKHDR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00918881; iTF_00590796; iTF_00590922; iTF_00600141; iTF_00600266; iTF_00918034; iTF_00917899; iTF_00918035; iTF_00917904; iTF_00915168; iTF_00915283; iTF_00916064; iTF_00916182; iTF_00914453; iTF_00917155; iTF_00917029; iTF_00914333;
90% Identity
iTF_00918881;
80% Identity
iTF_00918881;