Lmag002977.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Lordiphosa magnipectinata
Gene Symbol
Poxm
Assembly
GCA_018904285.1
Location
JBAMBO010000674.1:64757-65860[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7.7e-69 1.7e-65 219.2 0.4 3 125 16 138 14 138 0.99

Sequence Information

Coding Sequence
ATGTTTCTGCTCCATCTCGTTTCAGAGTCGCAATGTCCACAGTACGGCGAGGTGAATCAGCTGGGCGGCGTCTTTGTCAATGGTCGTCCGTTGCCAAATGCGACGCGCATGCGTATTGTGGAATTGGCCCGTCTGGGCATCCGACCCTGCGACATCTCCCGCCAGCTGAGAGTTAGCCACGGCTGTGTATCCAAAATACTGGCACGCTACCACGAAACGGGCTCCATTTTACCCGGGGCCATTGGCGGTTCTAAGCCACGGGTGACCACACCCAAGGTGGTAAACTATATACGCGAGCTGAAGCAAAGGGATCCGGGCATCTTCGCCTGGGAGATACGTGATCGACTGCTTAGCGAGGGCATCTGCGATAAGACGAATGTACCCAGTGTTAGCTCCATTTCACGCATCCTGCGCAACAAGTTGGGCAGCATAGGTCACCACCACACACCTGGCGGATCTGGATCGGGGTCCAGTCTGGGCAACAACTCTAGTGGAGTGaacggaggaggaggaggcggaggTGGAGGCAACAACGTAGGCAACTCAGGCAGCATGAATATGGCCAACTCTCACACTGGCCCCTCCTCGCAtccccatcatcatcatcaccatcacTCAGCAGCCGCAGCGGCGGCCAGTGCTCATCATGTCCATGCTCATGCCCACCTCTACAATTCCATCTACCAGCCGTATAGTGCAGCTGCCGCCTACAGCATGAAAGCCGTCTCTTGTGGTAGTCCCTCACCTCCCCAGGGGGCCGGAGCTCAAGCGCATCCGCATCAGTTGCGTAGCGTAGCCGCAGCCGCTGCCGCCCACTGGCCCTCATCGCACTCGGTCAGCGATATTCTGGCACATCATCAGGCTGTGGCTTTAAGGGCCAGCTGCCAGGTGGGAGTGGGAGTTGGCATGGGTAACACAGTATCGCCACTGCCCATGACCCCGTCGCCAGTAGCCGGTTCAGCCGGTGGGCAAGCGCTGCTCGACTGCGAGGGTGGTGCGGGCCAACAGCCGCCCTACAACTATTACATGTACTTTCAAAATGGAGGAATGCATCATCACCATCACCATGGTGGCATGATGGCTGCCGGAGCCACAGGCTTATGA
Protein Sequence
MFLLHLVSESQCPQYGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISRILRNKLGSIGHHHTPGGSGSGSSLGNNSSGVNGGGGGGGGGNNVGNSGSMNMANSHTGPSSHPHHHHHHHSAAAAAASAHHVHAHAHLYNSIYQPYSAAAAYSMKAVSCGSPSPPQGAGAQAHPHQLRSVAAAAAAHWPSSHSVSDILAHHQAVALRASCQVGVGVGMGNTVSPLPMTPSPVAGSAGGQALLDCEGGAGQQPPYNYYMYFQNGGMHHHHHHGGMMAAGATGL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00915280; iTF_00919773; iTF_00471560; iTF_00916179; iTF_00500257; iTF_00498821; iTF_00482182; iTF_00522119; iTF_00609833; iTF_00573998; iTF_00514127; iTF_00560207; iTF_00619791; iTF_00598832; iTF_00558611; iTF_00566741; iTF_00495062; iTF_00497334; iTF_00511222; iTF_00501752; iTF_00552984; iTF_00593048; iTF_00535259; iTF_01323325; iTF_00597310; iTF_00500993; iTF_01320417; iTF_00519108; iTF_00509765; iTF_00610597; iTF_01326341; iTF_01321866; iTF_01324059; iTF_01322592; iTF_00590919; iTF_00577729; iTF_00568200; iTF_00599529; iTF_01327113; iTF_00583626; iTF_00618346; iTF_00492907; iTF_00601003; iTF_00528748; iTF_01324844; iTF_00571087; iTF_00604038; iTF_00503217; iTF_00612022; iTF_00555031; iTF_00523643; iTF_00585137; iTF_00601727; iTF_00542387; iTF_00557154; iTF_00577011; iTF_00498100; iTF_01321139; iTF_00555796; iTF_00514837; iTF_00521301; iTF_00614135; iTF_00595196; iTF_00549497; iTF_00479430; iTF_00551534; iTF_00554332; iTF_00568924; iTF_01327837; iTF_00579230; iTF_00560983; iTF_00470815; iTF_00478668; iTF_00611298; iTF_00600264; iTF_00483637; iTF_00506058; iTF_00490727; iTF_00802791; iTF_00832103; iTF_00901448; iTF_00805129; iTF_00588787; iTF_00598099; iTF_00530901; iTF_00803545; iTF_00805914; iTF_00534528; iTF_00608388; iTF_00557856; iTF_00530213; iTF_00547304; iTF_01570185; iTF_00516204; iTF_00573267; iTF_00584374; iTF_00506809; iTF_00575529; iTF_00522906; iTF_00585915; iTF_00495804; iTF_00567484; iTF_00563850; iTF_00487244; iTF_00529515; iTF_00511955; iTF_00494333; iTF_00804335; iTF_00474451; iTF_00481491; iTF_00487945; iTF_00475882; iTF_00477287; iTF_00579927; iTF_00615511; iTF_00538905; iTF_00566028; iTF_00550202; iTF_00580659; iTF_00574758; iTF_00535987; iTF_01319702; iTF_00533049; iTF_00489322; iTF_00527254; iTF_00491458; iTF_00488612; iTF_00569637; iTF_00525830; iTF_00571845; iTF_00602533; iTF_00505350; iTF_00614855; iTF_00503939; iTF_00545914; iTF_00490025; iTF_00507562; iTF_00581482; iTF_00536715; iTF_00578486; iTF_00524363; iTF_00548013; iTF_00477966; iTF_00482926; iTF_00590186; iTF_00606253; iTF_00480112; iTF_00531602; iTF_00609118; iTF_00613454; iTF_00605522; iTF_00486515; iTF_00492179; iTF_00561704; iTF_00592339; iTF_00543073; iTF_00596595; iTF_00539608; iTF_00617589; iTF_00588086; iTF_00593784; iTF_00612760; iTF_00515545; iTF_00485083; iTF_00504636; iTF_00541020; iTF_00607742; iTF_00591648; iTF_00619099; iTF_00337466; iTF_00338282; iTF_00335827; iTF_00917152; iTF_00914450;
90% Identity
iTF_00916179;
80% Identity
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