Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 8e-38 8.4e-35 119.1 0.0 2 85 65 147 64 149 0.97

2 3 2.7 2.9e+03 -1.2 1.3 46 82 229 267 204 273 0.58

3 3 1.9 2e+03 -0.7 2.3 35 59 258 281 230 291 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	8e-38	8.4e-35	119.1	0.0	2	85	65	147	64	149	0.97
2	3	2.7	2.9e+03	-1.2	1.3	46	82	229	267	204	273	0.58
3	3	1.9	2e+03	-0.7	2.3	35	59	258	281	230	291	0.80

Coding Sequence: ATGGATACAACAACCGTAGCATCGCATGTCTTCCAGTCTAGTTTCTCCATACGCTCCCTGTTGAATGATAGCAAGGAGTATAAGCGTTACCATGACCCGCCACCCGCCAGTCCGAGCGATTCTGAGGGCACCGAGGGCAGTGAGGATGCCTCCTCCGATGAGGCCAAGAGCCTCAGGGGCAAGAGTGACACCAAGCCCGCCTACACCTACAGCGCCTTGATTGTGATGGCCATACGGAGCAGCGTGGAGAAGCGTCTAACGCTGAGCGGCATCTGCAAGTGGATAGCCGACAACTTTGCCTACTATCAGAATCACAAAAGCGTTTGGCAGAACTCCATACGCCACAACCTGAGCCTGAATCCTTGCTTTGTGCGTGTGCCCCGGGCACTGGATGATCCCGGCCGTGGTCATTACTGGGCACTAGATCCGTATGCTGAGGACTTGACCATAGGCGAGACGACGGGTAGACTGAGGCGCAGCAATGCGTCTGCCCAGCAGTTGATGGGACGCAGCAGCAAGCAGCTGCAGCTGGGGGGCAAGTGCCATGGGCATCCCTATCAGCAATTGCAGTATGCCCAATACTTTCAGCCGCAGGTTGCTTATTTTCCCATCACCAGTGatcggcagcaacagcagcagcagcagagacaGGCAATCATGATACAGAACTatacacagcagcagcagcagcagcaggcgcaACGACAACAGGCGACGCTATCAACGCACTaccatcaacagcagcagcagcagcctcatCCTCGACCCGGCCACCACAATTACTACCAGCGACAtcagcaacaactgcaacagcaacagcaacacaacTTTTACctccaacaacagcagcaacaacagcaatatgCAACCGCCTATGGCCTCTGGCGTTAG
Protein Sequence: MDTTTVASHVFQSSFSIRSLLNDSKEYKRYHDPPPASPSDSEGTEGSEDASSDEAKSLRGKSDTKPAYTYSALIVMAIRSSVEKRLTLSGICKWIADNFAYYQNHKSVWQNSIRHNLSLNPCFVRVPRALDDPGRGHYWALDPYAEDLTIGETTGRLRRSNASAQQLMGRSSKQLQLGGKCHGHPYQQLQYAQYFQPQVAYFPITSDRQQQQQQQRQAIMIQNYTQQQQQQQAQRQQATLSTHYHQQQQQQPHPRPGHHNYYQRHQQQLQQQQQHNFYLQQQQQQQQYATAYGLWR

Sequence clustering based on sequence similarity using MMseqs2