Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0021 11 6.5 0.1 19 46 135 162 125 164 0.91

2 6 0.00064 3.4 8.1 0.1 21 46 165 190 161 196 0.87

3 6 9.2e-05 0.49 10.8 0.5 21 44 193 216 189 220 0.91

4 6 0.00051 2.7 8.4 0.3 21 51 221 251 217 254 0.86

5 6 0.046 2.4e+02 2.2 0.4 22 44 250 272 245 284 0.69

6 6 0.00075 4 7.9 1.2 13 48 269 304 263 307 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0021	11	6.5	0.1	19	46	135	162	125	164	0.91
2	6	0.00064	3.4	8.1	0.1	21	46	165	190	161	196	0.87
3	6	9.2e-05	0.49	10.8	0.5	21	44	193	216	189	220	0.91
4	6	0.00051	2.7	8.4	0.3	21	51	221	251	217	254	0.86
5	6	0.046	2.4e+02	2.2	0.4	22	44	250	272	245	284	0.69
6	6	0.00075	4	7.9	1.2	13	48	269	304	263	307	0.93

Coding Sequence: ATGAACCAGGAGCGTGCCTGTCGCGTCTGCTTGGCCAATAGCGTTATGCTGGTGCACATATTCAATGAGCCGGAGCAGCTCCAGCGGCAGCGGGAACATTTACCCACTTTGATGGACATGCTGAACGAATTTTGTGAGACGCGACCTGATGATCCCTTGCCTGCACACATCTGCTTGAGCTGTGCCCTGGCGGCAGAGAATGCCTTTAGGTTCAAGCGCAAGTACGAGGAGAGCCAACGTCATTTCTATCAGCTAACGTCCCTGGATGGTGGCTTACAAAGCGAAGCACAACCCGAGACCCACATCGATGTGAGTTGTGTGAAAATTGAAACGGAGGAGGAAGAGCAACAGCAGCCAAGTTACCACATCATTACAGAGGATCCCTTGCTGGAGCCACTACCCAGCCAGAGTCAGATGGGTTTCCAGTGTCCCTATTGTCCACAAATGTTCACTCTCAATCACAATCTCAAAGCTCACTTACGCATACACACGGGTGAACGGCCCTTCAAGTGTCCCGAGTGCGGGCAAACCTTTAAACAGAATCAGCATCTAACCAAGCATCTGCGTTGGCATACGGGAGAGAAGCCCTACAGTTGTCCGCATTGTTCGCAATCCTTTGGCCAAAGTCAGCACTTGCAGCGACATATACGAACCCATACGGGCGAACGACCCTACAAGTGTCCACACTGCCCATCGGCCTTTCTGGCCAGTGAGAATCTCAAGACCCATATACGCATACACACAGGCGAAAAGCCCTTCAAGTGTAACTACTGTGGCAAGGCCTTTGCCGATAATAATAATCTAAAGAAACACCGGCGACGTCATACTGGCGAAAGACCCTTCAATTGTCCACACTGCCCAAAGGATTTCAAGGAACGGCATCACTTAAAAGCGCATGTGGCGGTGAAGCATCGGGATATCAAGGAGCAGCAAGCGGAATCACTGCCCACTGCACAGCAAGTGTTGGAGTTTGATTTAAATCTAGTAGAAACTGAATTAAATTCATTACATTCTTTTTGA
Protein Sequence: MNQERACRVCLANSVMLVHIFNEPEQLQRQREHLPTLMDMLNEFCETRPDDPLPAHICLSCALAAENAFRFKRKYEESQRHFYQLTSLDGGLQSEAQPETHIDVSCVKIETEEEEQQQPSYHIITEDPLLEPLPSQSQMGFQCPYCPQMFTLNHNLKAHLRIHTGERPFKCPECGQTFKQNQHLTKHLRWHTGEKPYSCPHCSQSFGQSQHLQRHIRTHTGERPYKCPHCPSAFLASENLKTHIRIHTGEKPFKCNYCGKAFADNNNLKKHRRRHTGERPFNCPHCPKDFKERHHLKAHVAVKHRDIKEQQAESLPTAQQVLEFDLNLVETELNSLHSF

Sequence clustering based on sequence similarity using MMseqs2