Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.6 2.1e+03 -1.4 0.0 1 13 9 21 9 22 0.89

2 3 1.9e-09 6.7e-06 25.9 0.0 34 75 55 92 50 94 0.91

3 3 6.1e-06 0.021 14.6 0.0 27 76 185 245 176 246 0.90

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.6	2.1e+03	-1.4	1	13	9	21	9	22	0.89
2	3	1.9e-09	6.7e-06	25.9	34	75	55	92	50	94	0.91
3	3	6.1e-06	0.021	14.6	27	76	185	245	176	246	0.90

Coding Sequence: ATGCAAATGAATCCAAGTGTGACAATAGAACGCAAACGCGTCGATTGCAGTGCCCTGCCCAAGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTCTATTACAGTCCAACAGGCAAAAGAATTGAAAGCAAGCCACAATTAGCTCGTCAATTGGGCAGTGAAATGTTTGACATTGGCAACTTTGATTTTCAAACTGGCAAAATGCTGCACCACCAGCAGCTTCACCGTCAATTGCCCTCACCCTCGATATCGCTATACCGCTGCAGTGTGATGCCACCGCTGCCCGGTTGCGGAGCAGCGGGCAATCTTAAACGCAAGTATACCAGAGCCCAGGCCCAGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCACCTCGTCTACCAATCTACGCCATCAACAGCAATTCGAACTCAGTCGCGCCCTACGCACAGATGTCTCCCTGGTACCACCCATACGCCAAACTGCCTCAATTTTTAAGCAACCTGTCACGGCTATTCGTAATCACAATCAGGATTCCGGTAAAGTTAAACACGATGCCAAACACGGTGCCCAAGAGAAACCGAAACAATTGTTCTGGGAAAAGAGGCTGGAACGATTACGTGCATGCCACGACAATGGTGAAGAGCTAGATGACATATCACTGCCCAAAACCATACGCACCGTGGGCCCCAATGTCAACGAACAGACTGTCCTGCAATCGGTGGCCACCGCCCTGCATATGCTCAATGCCGGAGTGCATGGTCAGAGCAGTACTAAGGCTGAGTTAACCAAGAATGCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNATACGCAAGCAGGAGGATCGCGTCAGTGTGGCGCGACGAAAGCTACAGGATGCGCTGAAAACATGA
Protein Sequence: MQMNPSVTIERKRVDCSALPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFYYSPTGKRIESKPQLARQLGSEMFDIGNFDFQTGKMLHHQQLHRQLPSPSISLYRCSVMPPLPGCGAAGNLKRKYTRAQAQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTSSTNLRHQQQFELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHNQDSGKVKHDAKHGAQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAXXXXXXXXXXXXXXXXXXXXIRKQEDRVSVARRKLQDALKT

Sequence clustering based on sequence similarity using MMseqs2