Lclr002975.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Lordiphosa clarofinis
Gene Symbol
MBD-R2
Assembly
GCA_018904275.1
Location
JAEIGQ010000231.1:220653-237720[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.3e-22 1.2e-18 66.6 0.1 4 76 451 521 448 522 0.93

Sequence Information

Coding Sequence
ATGGGGCGTCGCTGCTGTGTGGCCAATTGTCCGTCAACATCGCGTCTGCTTGAGCACCATGGCGTCACCTACCACTCGTTCCCGCAGGATCCTGTCATACGGGCAATTTGGATCAAAAACTCACGTATTAGCCTGGACAAGCAGATCACCAAAAGTGTTTTGGTCTGTTCGCGGCACTTTCGTCGCTTGGACTTCAACACCATTCGGAATGGCAAATATTTGCTAAAGCCGCGTGTCTTCCCCACCGTCTTTCCATGGGGAAAAATGGACACCTCTGAAATCGAGGCTGATCATCGGGCCTTGCAGCAAGCCAATGTGGATGGTACTTCGGGAGTGGCCGGCAGCGGTGCAAGTACTTCGGCCAATGAGGATGTCATCAAGGCCACTGTGGATCAAATTGTGGAACAAATTCTGGCGGAGACGGCGGAAAGAAACGCGGCAGCTGCAGCCCAGGCCAAGGTCAAGGAGGAGGAGCACAAGGAAACGACAGTCAAAGCAAATAACGAAGTGCTCACGGGGAGTATACCTAAAACTGAAGAAGAGGTGCCCAGTACTTCAGCTGCTGCTGCGGCCATAAGTGAGGCCGGAACTGCCACTTCTACGCCTGACACCAGTTCGCCCCTGCCCACAGCCTCGCCACCGCCGAAATACTGTAATCCCACAAATCTGGCCATCGGAGCACGCTTGGAGGCCCAATCGGTAGATGGTATATGGTTGCCTGCTCGCATTGTGGAAGTAAATGAAACGGAACAAACTCTGCTGGTGCGCTTCGATAAGAGTAGCAAGCTAAAGACATCCCCCTCAACCAGTGGCAGTAACCAGGAATGGCTGACCATTAAATCGGAACGCTTGAGGCAACGTGTTCAGCGTACACTGCCCTTATTTGAGCTGGAGGAGAAATGCATGGCACGCTGGTCCGGTCCCAGGAAATTTCCAGGCACAATTAAAAAACTTTTGGGGAATGACACCTACGAAGTGCTCTTCGATGATGGTTATGTCAAGAATGTACGTGCAGTGCATATGAACAAGTTGCCCAGGCAGTTGGTAGTTCTCGATGGCATGGATGTGTCTACGCCGGCACCAGCTAGTGTCAAGCCGATAGTGGGTACCAAAAGATCCAGCGTGGGAGCTGGTTCAGGGTCAGTGACATCTGGTTCATCAGGCAGCAAAAAGAGCAAGAGCACACCACAGCGCAAGGACTGGCCTTTGCTGGATATGGCTACTTTAGATATTGCCTCTCTCGGTTTACCCGAAATACCAAAAGATGGCGAGTGGACCTGCCACTGGGTTAATGATCAACCAATCGGCTCAGAGGGATTCTTGGTGGTGGGTGAACATCAAAAGCCCACAGTGGTTGTGAACGATTGGCGACTGCCGCCGGGTTGGATTAAGCACATGTATCAACGCTCCAATGTCCTAGGCAAATGGGATGTCATTCTGGTCTCACCCAGCGGCAAACGTTTTCGTTCGAAATCGGATCTCAAAGTGTTTCTGGAATCGCAGAATTTGGTGTACAATCCAGATGTTTACGATTTTAGTATTCATCGCCGACGGGCCAAGGATATTAATGCCTATGTCTATACACAAGACTACACACCGCAGCCGGCGCACAGGCCCAAAACAATGGATGTGTCTTTGGAGACATCTATGGATCAGATGAATGCCAGCAAATTGCCGGCGCTTACTTCAACGCCGCTACCACGACGGGGAGCCGAGGATAATCAATATATGGAGACACCGGTGGCCACTTTAATGCCACCAGCTGAACTAATGTCGCCACAGGCTCAACTAGGAGAGACTGGAGAAAAGCTGGCGGGTAATCAAACGGAATTGGGTGAAGGAGGCGGCAGCTCAAATCTGACAGTTGAACCAGGTGCTGCTCCTGTCGAAAATGGTTTCGTTTTTATTGGTGGCCTAAAGGTTCAGATAGCGGATAATTTATTTGTGTGTCCTCGAGAGGATTGTGGAAAGACCTATCGCAAGGAGGATTTCTTACAAATTCACATACGTCATTATCACAAGGAGTTTGCCGAATATGTCAGCCACTGTCCCAAGATGCAAGAGCTGGCCGTTAAGCGCACCCATCCTTCTTCTATGGAGCAGGGTGATGCCACACCCAAGAATCAAATACCAAACCAACAATTCTTTGCCAAATTGCATCAGCAGGATATGCTGCAAACCAGATCCTTGAGAAGGCAAGGCGCGCCTGCAGTCACAACCTCACCCACAACAGCTCTGGGTACGCCACCAAGGGTTTCACCCAACAAACCCTTGGAAGAGCAAGCCGGAACGCCCATTTCTTTAGAAAATCAAGCTAATCCAGAGTTGGGTGTGACTTCAAATACACCAAATCCTTTGTTGCCACCACTGGAGACCAGTAATCTTGCATTGAACTCTTCCATGCAACGTACGGCTGTCAAGCGGTCTCGTTTCTCACCCAGCAAACGTACCTCGGGCTCCAGAAAAAGCAATCGTCAGCGTACACAACGAAGTTATACCGAGATGCCACCCAATACCACCTCACTGGCGGATCATGACTCGGAGGACACGCGTCAATCCACTCCAGATGCGGCTAAGAAACGTCGTGTGGCTGCCACGCCCATTAGCTCTATAGACTCCCCTGCCACCGCTGATTCTGTATCCACACCCTCTTCAAATGACCATGCAGACATTAATGCTGCTCTGGCCCCTCCGCCGGCCCTGGAGAATCAACCTCCTCAGTACATAAAGGAGAACGGGGAACTCATTCGCATAGTGCGTATGCGGCAGGAGGAGATTATCAATTGCATTTGCGAATATGGTGAAGAAGATGGTCTAATGATTCAGTGTGAACTCTGTCTGTGCTGGCAACATGGCGCCTGCAATGGCATTGTCAAGGAGTCCGATGTGCCGGACAAATATGTTTGCTACATTTGTCGTAATCCGCAACGTGGACGAGACTCGATGAGATTTAAACACGATCAGGACTGGTTGTTTGAGGGAAAATTGCCGGTGGCATCCTATCACACAGCCAATCCGCAGGTGGCCAAGCAATTTGAGCTACTTAAGAAATCGCACACCCTAACGGGAAATCTATTGGATGCCAAGCGTTCCATGCATTCGTTGCAGGTGAAAATTAATATTGCACGCAATCGTTGTCATCCCAAGCTATATTTATGGGCCAAGAAATGGGATGAGGATCAGTTGGGGGATGCATCAACGGCTCTGTCCCTAAAGCGTCCAAAGTCAGAGCAGCCGAATTTACCACATGTACCCCAACCGGAGGCTGCTATCGATCCGGAGGAGTGTCAATATCGGTTAATTGAACACGTGAAAGTACAACAGGAGTTGGTGATGAATCGACTCACTGACATCGAGGCGGAAATGGATGAACTGGAAAAAGAGGATAATCTGGAGGATTTGAAAGACGCCGATTTATCCATCACCAAAGATGCCCTGGCCACATTCATCAAGGAATTGGAAACTCTCAAGCGCCTGTCCAAGCTAAACAAAGTGGCCAACATGAAAGAGTCTCTGAAAGAATCATCCACGGTGTCGGCCAGTCTACCATTGTAA
Protein Sequence
MGRRCCVANCPSTSRLLEHHGVTYHSFPQDPVIRAIWIKNSRISLDKQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDTSEIEADHRALQQANVDGTSGVAGSGASTSANEDVIKATVDQIVEQILAETAERNAAAAAQAKVKEEEHKETTVKANNEVLTGSIPKTEEEVPSTSAAAAAISEAGTATSTPDTSSPLPTASPPPKYCNPTNLAIGARLEAQSVDGIWLPARIVEVNETEQTLLVRFDKSSKLKTSPSTSGSNQEWLTIKSERLRQRVQRTLPLFELEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYVKNVRAVHMNKLPRQLVVLDGMDVSTPAPASVKPIVGTKRSSVGAGSGSVTSGSSGSKKSKSTPQRKDWPLLDMATLDIASLGLPEIPKDGEWTCHWVNDQPIGSEGFLVVGEHQKPTVVVNDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLESQNLVYNPDVYDFSIHRRRAKDINAYVYTQDYTPQPAHRPKTMDVSLETSMDQMNASKLPALTSTPLPRRGAEDNQYMETPVATLMPPAELMSPQAQLGETGEKLAGNQTELGEGGGSSNLTVEPGAAPVENGFVFIGGLKVQIADNLFVCPREDCGKTYRKEDFLQIHIRHYHKEFAEYVSHCPKMQELAVKRTHPSSMEQGDATPKNQIPNQQFFAKLHQQDMLQTRSLRRQGAPAVTTSPTTALGTPPRVSPNKPLEEQAGTPISLENQANPELGVTSNTPNPLLPPLETSNLALNSSMQRTAVKRSRFSPSKRTSGSRKSNRQRTQRSYTEMPPNTTSLADHDSEDTRQSTPDAAKKRRVAATPISSIDSPATADSVSTPSSNDHADINAALAPPPALENQPPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLPVASYHTANPQVAKQFELLKKSHTLTGNLLDAKRSMHSLQVKINIARNRCHPKLYLWAKKWDEDQLGDASTALSLKRPKSEQPNLPHVPQPEAAIDPEECQYRLIEHVKVQQELVMNRLTDIEAEMDELEKEDNLEDLKDADLSITKDALATFIKELETLKRLSKLNKVANMKESLKESSTVSASLPL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00915373; iTF_00914500; iTF_00914544; iTF_00916275; iTF_00916231; iTF_00917207; iTF_00917252; iTF_00919098; iTF_00919052;
90% Identity
iTF_00914544;
80% Identity
iTF_00915373;