Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.007 30 5.1 0.1 23 45 37 59 27 62 0.86

2 7 0.0071 30 5.1 0.0 20 45 62 87 59 91 0.88

3 7 0.0012 5.1 7.6 0.4 21 44 91 114 87 118 0.81

4 7 0.072 3.1e+02 1.8 0.1 21 46 119 144 116 149 0.89

5 7 0.27 1.1e+03 0.0 0.1 24 44 160 180 157 183 0.80

6 7 0.0086 37 4.8 0.0 20 46 184 210 176 212 0.84

7 7 9.3e-05 0.4 11.1 0.1 21 47 213 239 211 244 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.007	30	5.1	0.1	23	45	37	59	27	62	0.86
2	7	0.0071	30	5.1	0.0	20	45	62	87	59	91	0.88
3	7	0.0012	5.1	7.6	0.4	21	44	91	114	87	118	0.81
4	7	0.072	3.1e+02	1.8	0.1	21	46	119	144	116	149	0.89
5	7	0.27	1.1e+03	0.0	0.1	24	44	160	180	157	183	0.80
6	7	0.0086	37	4.8	0.0	20	46	184	210	176	212	0.84
7	7	9.3e-05	0.4	11.1	0.1	21	47	213	239	211	244	0.89

Coding Sequence: AATAATGCAAGACAGAGGAAAAGGAGCCCTGATGCCGTCACATTACTGAGTAAATCGTATATACAGAGAAGTGACTTAAAGAACCACTTGCGCAAACATACAGGTGCACGACCCTTCAGTTGTACTGTGTGCTACAAGAAGTTCACGAGTAGCAGTGTCCTAAATGTGCACTTGCGTGTACATTCATCTGAACATCCCTTCAAGTGCACTGTGTGCAGCAAGACTTTCAAATGGAAAAGCAACCTGACAACCCATTTCCGTATCCACACAGCCGAAAGGCCTTTTACTTGTACTGTGTGTTACAAAAGTTTTACTAAGAGATGTATCCTGAGTAAACACATGTATGTACACACAGATGAACGCCCATATAGTTGCAATGATTGCAGCAAGACGTTCAAAACAGCCCATTATTTGAGAATGCATATGAGAGTACACAAGGGTGAACGTCGTTTCATCTGCTCTTTTTGTGGTCTACGACCTTTTAGCTGTTCTATATGCAGTGAGAATTTCACATGTAGCGTCATCCTAAAACAGCACATGCGTACACACTCTTCCGAACATCCCTTCTCATGCAATATGTGCAACAAGACATTTAAATGGAAAAAAGTCCTAACATCGCATTTGCGTATCCACACTGGAGAACGCCCATACCGCTGCTCCGTGTGTAGCAAGATGTTTAAAGACAGCAGTAATTTAAACCAGCATTTGCGTGTCCACTACGTGAATGGGGCTTCAGTTGCAAGATCATTAGTAAGCTATTTATAG
Protein Sequence: MSKQPATDQWLLQFLTYEDYLDSLVTPHDLLYLRSREAARTIAELGYRNPNTLSREQFESRRRLAALFQTPALLEQRDCSMLAGPISDPLLVALADRERANRRGDLATIIFIRLVDRAGHQVSGYVDFAHRIACESWLRIFSGTKQLWPRTTDLGYFNWHTRVTKTNSSPNFTQNGELSFCRHETVPRISSTYYYVEPQGLFSNFPIRMTYHHARIFCELEGGRLAVPGSVDVYKKLAEQMVGVTRISKIWFGLNDRETEGTWLTVDGTRPPALPWANGHPDNKYNKDCAVLNYPEPTLIDARCSGERPFLCERGLRKPIPAGYVWCAPAQVFYKHYRTEKVYPEAKRQCEQDGGSLVSITTVEEARCVLQQLPAPWNDPFVDYTDEAVEGVFVNSKDDAGK

Sequence clustering based on sequence similarity using MMseqs2