Basic Information

Gene Symbol
Zfy2
Assembly
GCA_949126875.1
Location
OX421396.1:35445622-35447680[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.0038 0.77 11.9 1.7 1 23 113 135 113 135 0.98
2 16 2.9 6e+02 2.9 0.8 2 23 141 162 141 162 0.90
3 16 0.0009 0.18 13.9 8.3 1 21 168 188 168 190 0.95
4 16 2.6e-07 5.4e-05 25.0 1.3 1 23 196 218 196 218 0.97
5 16 2 4e+02 3.4 1.8 1 22 226 247 226 248 0.70
6 16 7.5e-05 0.015 17.3 0.4 2 23 255 276 254 276 0.97
7 16 0.001 0.21 13.7 0.4 1 23 281 304 281 304 0.97
8 16 0.054 11 8.3 8.8 2 23 308 329 307 329 0.95
9 16 2.2e-05 0.0045 19.0 1.6 1 23 335 358 335 358 0.96
10 16 1.2e-07 2.4e-05 26.2 0.2 2 23 366 387 366 387 0.98
11 16 8.2e-09 1.7e-06 29.8 1.3 1 23 391 413 391 413 0.99
12 16 3.1e-06 0.00064 21.7 1.5 1 23 419 441 419 441 0.99
13 16 0.00044 0.091 14.9 2.4 1 23 447 469 447 469 0.97
14 16 6.7e-05 0.014 17.5 1.7 1 23 475 497 475 497 0.98
15 16 0.00025 0.051 15.7 5.0 1 23 503 527 503 527 0.92
16 16 0.0029 0.6 12.3 0.5 1 21 535 555 535 558 0.87

Sequence Information

Coding Sequence
atgaTGCCAATACAAATAAAATCGGAATCAAACAATGAACAATTTAACATTAAAACAGAATCTACCATAGAAAATGAATCCAAAGCTGAAGATAATTCTAACGTTGATTTACCTATTCTAAATGTAAAAATAGAACCACCAGAATGTTCTCCAAGCGAGAAAgtattaaaaatggaaataaaaccAGAATTGCCACTGGATTTTGAACCGAACCAGTCTGATATAGATCCATGTAAGAATATTGTAGATATTCacgaagaaaatttaaatatatctttTGAAGAACTGAAAGCACTAAACGACGATTTaactattattgaaaatgaaacCACTGTCTACAAGTGTCAAATATGTGAATTAGTCTTTATCAAGTATCAGGAATATAGgttacacaaaaaaaatcattatattGAGAAAAGAAGGTGTTATATTTGCCATAAAGTTCAGCAGAGTCTTGGTGTATTAGAAGAACATGTAAATAAGCATCTTGGTCTCAAACCTTATAAATGTGAAGAATGCGACAAATGTTTTGCTTCAAAAAACCACCTTAGTTTACATAAAAGATGCCATAATACTAGTGAGATTTATAAATGTCCAAAATGTGGTAAAGAATTCAGGACAAGTGCTTCTTTACGCAGTCATCGCTTTGTACATTATGAAAAAATAGTTGAAGATTTCAAATGCAAAGTTTGTGGTCATAGCTCTTTAGATGAAGCTAAGCACAAAGTTCATATGTCAATACATGCAAAAAAAGCAGAAATCAGATGTGAATTGTGTAAGAAAGCTTTCAATACTGAACGTGGCTTAGAAAGTCATCTAAGTACTCATAACGAATTGCAATTTCCTTGCGAATTTTGTGGTAAAATATATCCTTCAATGTATAGAATAAAAAGGCACATCAAAAGAGCCCATGCACCCTGTAAATGTGAACACTGTGATCAGGTTTTTCATGATCGTTTTCTTTATAATAAGCATAAAAAAGAACACAGTCAGCAAACCAAATATGAATGCGAATACTGCCAAAAAGTATTcgaaaaatccaaaaaccttTCCGAACACTTTCGTCTTCAGCACAAACAGGATGGAGAGAAGAGAAAATGTCCCATATGCGGCAAAGAATTCATCAACAACGCACTGTTGAAGAACCACatcaaaacacatgacaaatgcTTCAAATGTAACCTTTGCGATAAAGTATTTTCTTCTAGGTATAATCTAGAAATCCACATGAATACTCATTCCGGGGCGAAGAATTTCAAATGCGAAATATGCGGTAATCATTTCGCCAGCAAAACTAGTCTTAAAAATCACATTGCTACTCATTCGGATGAAAGAAAAtttcaatgtgaaatttgtGCTAAGACGTTTAAAACTTCCAGAAGACTCTATACGCACAGTCAAAGTCATGCTACCGAAGAAAAGTACCAGTGCGAGATTTGTCTACAGAAATTTAGagTCAAACAATACCTCAAAGCTCACATGTACAGACATTCCAAAGTAAAACCGTTTTCTTGTGACGTTTGCAAGAAGCGGTTCAAACATAAAAAAACGAAAGAAAAACACATGCGAATCGGAAAACACCAACACGTGTCCGAAGCAGAACACGATTGCGATTTTTGCGACGAAAATTTCTCCACCAGAGATTTGTTGTTGGATCACTTTGCTGCAGTTCATCACAATGAAAATGTTGTTAACGAATGCGAGAAAGATATCGAAGAAGATGAAGATAATAAGGAGTTGGATAATGTTGCAAATGGTGATGAAGTAACTGAAATGAAAGTAGATAGTACggaattttaa
Protein Sequence
MMPIQIKSESNNEQFNIKTESTIENESKAEDNSNVDLPILNVKIEPPECSPSEKVLKMEIKPELPLDFEPNQSDIDPCKNIVDIHEENLNISFEELKALNDDLTIIENETTVYKCQICELVFIKYQEYRLHKKNHYIEKRRCYICHKVQQSLGVLEEHVNKHLGLKPYKCEECDKCFASKNHLSLHKRCHNTSEIYKCPKCGKEFRTSASLRSHRFVHYEKIVEDFKCKVCGHSSLDEAKHKVHMSIHAKKAEIRCELCKKAFNTERGLESHLSTHNELQFPCEFCGKIYPSMYRIKRHIKRAHAPCKCEHCDQVFHDRFLYNKHKKEHSQQTKYECEYCQKVFEKSKNLSEHFRLQHKQDGEKRKCPICGKEFINNALLKNHIKTHDKCFKCNLCDKVFSSRYNLEIHMNTHSGAKNFKCEICGNHFASKTSLKNHIATHSDERKFQCEICAKTFKTSRRLYTHSQSHATEEKYQCEICLQKFRVKQYLKAHMYRHSKVKPFSCDVCKKRFKHKKTKEKHMRIGKHQHVSEAEHDCDFCDENFSTRDLLLDHFAAVHHNENVVNECEKDIEEDEDNKELDNVANGDEVTEMKVDSTEF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00736022;
90% Identity
iTF_00736022;
80% Identity
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